Diabetes and Breast Cancer: An Analysis of Signaling Pathways is an in-depth monograph that explores the cross-talk between diabetes and breast cancer. The edited volume sheds light on the complex relationship between the two diseases by explaining the critical regulatory signaling in their progression.
Topics covered in the book include the genetic similarities between type 2 diabetes and breast cancer, signaling pathways for breast cancer cell invasion and migration (including fat cadherin, Wnt signaling and IGF signaling).and research on associated conditions such as neuropathy, inflammation, hypoxia and obesity. A summary of new natural medicines for targeting these diseases is also included.
Scholars, academicians, and professionals in medicine and pharmaceutical research who want to gain a better understanding of the complex interplay between diabetes and breast cancer will learn about the underlying biochemical mechanisms, pharmacogenomics, and precision medicine approaches for the simultaneous management of both diseases
Topics covered in the book include the genetic similarities between type 2 diabetes and breast cancer, signaling pathways for breast cancer cell invasion and migration (including fat cadherin, Wnt signaling and IGF signaling).and research on associated conditions such as neuropathy, inflammation, hypoxia and obesity. A summary of new natural medicines for targeting these diseases is also included.
Scholars, academicians, and professionals in medicine and pharmaceutical research who want to gain a better understanding of the complex interplay between diabetes and breast cancer will learn about the underlying biochemical mechanisms, pharmacogenomics, and precision medicine approaches for the simultaneous management of both diseases
Key Features
- Gives a comprehensive overview of the cross-talk between diabetes and breast cancer
- Covers information on multiple signaling pathways and associated conditions
- Provides insights contributed by biomedical experts with detailed references
Readership
Research scholars, academicians, healthcare professionals (endocrinologists, oncologists, internal medicine specialists) and R&D professionals in pharmaceutical chemistry.Table of Contents
Contents- Foreword
- Preface
- Acknowledgement
- List of Contributors
- Susmita Patra, Ratul Chakraborty, Motlalepula G. Matsabisa and Asis Bala
- Introduction
- Insulin Resistance
- Inflammatory Cytokines
- Oxidative Stress
- Hyperlipidemia
- Receptor for Advanced Glycation End Products (Rage)
- Hyperinsulinemia
- Hyperglycemia
- Crosstalk Pathways Between Diabetes and Breast Cancer
- Genetic Influences Between T2Dm and Breast Cancer
- Conclusion
- References
- Sreemoyee Sensharma, Nilakshi Thakuria and Subrata Pramanik
- Introduction
- Neuroinflammation
- Neuroinflammatory Molecules
- Mechanism of Neuroinflammation
- Neuroinflammation in Cns
- Neuroinflammation in Pns
- Neuropathic Pain
- Pathophysiology of Neuropathic Pain in Pns and Cns
- Mechanisms of Neuropathic Pain
- Sensitization of Nociceptors
- Abnormal Excitability of Afferent Neurons
- Central Sensitization of Pain
- Peripheral Pain Sensation
- Neuropathic Pain in Breast Cancer and Diabetes
- Neuropathic Pain in Breast Cancer
- Neuropathic Pain in Diabetes
- Diagnosis and Treatment of Neuropathic Pain
- Challenges and Future Direction
- Conclusion
- Acknowledgements
- Orcid Ids
- References
- Ratul Chakraborty, Debanjana Das, Ayan Goswami, Rajan Rajabalaya, Sheba R.
- David, Ashok Kumar Balaraman, S. Hemalatha and Asis Bala
- Introduction
- Hypoxia in Breast Cancer
- Hif-1Α and Hypoxia
- Insulin and Cancer- An Overview
- Association of Pi3K/Akt/Mtor Signalling Pathway With Breast
- Cancer
- Cell Migration in Cancer
- Insulin Receptor Expression
- Role of Insulin in Cancer Cell Invasion and Migration
- Hypoxia and Breast Cancer
- Clinical Implications and Therapeutic Opportunities
- Conclusion
- Acknowledgement
- References
- Sandipan Jana, Suraj Kumar Chatterjee, Asis Bala and Pallab Kanti Haldar
- Introduction
- Involvement of Brca1 Gene in Diabetes and Breast Cancer
- Role of the Insulin Receptor (Ir) Encoded by the Insr Gene
- Role of P53 Gene in Breast Cancer Development in Diabetic Patients 69
- Wnt-1, Ret and Neu Oncogenes in Ir Overexpression
- Overview of Genetic Association
- Conclusion
- References
- to Decipher the Interconnections
- Pervej Alom Barbhuiya, Ireenia Warjri, Priyam Jyoti Das, Shiny Ahmed, Kalyani
- Pathak, Abdul Mannaf Laskar and Manash Pratim Pathak
- Introduction
- Pathophysiology of Breast Cancer in Non-Obese, Non-Diabetic
- Subjects
- Pathophysiology of Breast Cancer in Obese Diabetic Subjects
- Adipose Tissue in Estrogen Receptor Activation
- Treatment Strategies
- Dietary and Lifestyle Approach
- Balanced Diet
- Portion Control
- Limit Added Sugars and Processed Foods
- Regular Physical Activity
- Weight Management
- Stress Reduction
- Adequate Sleep
- Avoiding Smoking and Limiting Alcohol Consumption
- Regular Health Check-Ups
- Conventional Treatment Strategies for Breast Cancer in Obese Diabetic Patients
- Surgery
- Radiation Therapy
- Chemotherapy
- Hormone Therapy
- Targeted Therapy
- Immunotherapy
- Follow-Up Care
- Potential Drugs from Natural Sources
- Curcumin
- Resveratrol
- Epigallocatechin Gallate (Egcg)
- Quercetin
- Omega-3 Fatty Acids
- Sulforaphane
- Repurposed Antidiabetic and Anti-Obesity Drugs Against Breast Cancer
- Conclusion
- References
- Barsha Dassarma, Satyajit Tripathy, Mohammed Alsaweed, Ns Trivedi And
- Motlalepula Gilbert Matsabisa
- Introduction
- Molecular Events of Breast Cancer Progression
- Role of Cadherins on Breast Cancer Progression
- Fat Cadherin in Breast Tumour Progression
- Influence of Fat Cadherin in Tumorigenesis Through Hippo Signaling Pathway
- Altered Immune Response in Tumour Microenvironment
- Wnt/Β-Catenin Signaling by High Glucose
- Conclusion
- References
- Bidita Khandelwal, Chamma Gupta and Abhishek Byahut
- Introduction and Epidemiology
- Mechanisms Linking T2Dm to Breast Cancer
- Impact of Hyperglycemia on Cancer Cell
- Cancer Cell Proliferation
- Resistance to Apoptosis
- Cancer Cell Migration and Invasiveness
- Impaired Glucose Metabolism and Breast Cancer
- Insulin Receptor, Igf1 and Insulin Resistance (Ir)
- Oxidative Stress in Diabetes Mellitus and Breast Cancer
- Impact of Antidiabetic Therapeutics on Breast Cancer
- Conclusion
- References
- Debjeet Sur and Susmita Roy
- Introduction
- Igf Signalling in Breast Cancer
- Tumour-Associated Macrophage in Breast Cancer
- Igf Signalling in Tam Polarization
- Tam Polarization Pathways
- Il-4 Pathways
- Stat3 Pathways
- Conclusion
- References
- Piyali Devroy, Ratul Chakraborty, Sanjib Bhattacharya and Asis Bala
- Introduction
- Pathology of Diabetes Mellitus
- Pathology of Breast Cancer & World Scenario
- Medicinal Plants With Concomitant Anti-Diabetic and Anti-Cancer
- Effects
- Conclusion
- Acknowledgement
- References
- Subject Index
Author
- Asis Bala
