Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field.
The tenth volume of this series features 4 reviews on the following topics:
- Pharmacotherapy of Posterior Segment Ocular Infections
- Discovery and Development of Antimalarial Drug-Resistance Reversal Agents
- Omics Technologies and Anti-Infective Drug Discovery
- Possible Cutaneous Adverse Effects of Anti-Infective Vaccinations
Readership
Pharmaceutical scientists and post-graduate students in pharmacology and medicinal chemistryTable of Contents
Chapter 1 Managing Posterior Segment Ocular Infections: a Review- of Pharmacotherapy
- Saurabh Verma, Abhidnya Surve, Shorya Vardhan Azad, Kumar Parmanand, Vinod
- Kumar, Rohan Chawla and Pradeep Venkatesh
- Introduction
- Endophthalmitis
- Sample Collection and Lab Testing
- Bacterial Endophthalmitis
- Antibiotics
- Role of Corticosteroids
- Role of Pars Plana Vitrectomy (Ppv)
- Fungal Endophthalmitis
- Management of Subretinal Abscess
- Viral Infections
- Hsv, Vzv Retinitis
- Cmv Retinitis
- Measles
- Dengue
- Chikungunya
- Parasitic Infections
- Toxoplasma
- Conclusion
- References
- Resistance Reversal Agents
- Phanankosi Moyo, Vinesh Maharaj, Sephora M. Mutombo, Warren Andrew Andayi,
- Linda Amoah, Kathithileni M. Kalili, Kwame Kumi Asare and Cynthia Amaning
- Danquah
- Introduction
- Malaria: a Health, Economic and Social Challenge
- Malaria Control: the Perpetual Challenge of Drug-Resistance Emergence and Spread
- Drug-Resistance Reversal Strategy: a Noble Approach to Complement Drug Discovery And
- Development Efforts
- 4-Aminoquinolines, a Class of Antimalarials Worth Preserving
- Discovery and Development of Resistance Reversal Agents for 4-
- Aminoquinolines
- Synthetic Compounds as Resistance Reversers of 4-Aminoquinolines
- Verapamil - a Classical 4-Aminoquinoline Drug-Resistance Reversal Agent
- Reversed Chloroquine: Chloroquine-Reversal Agent Conjugates or Double Drugs
- 3-(Substituted-Phenylmethylene)-Pyrrolidines as Chloroquine-Resistance Reversal
- Agents
- Adamantane and Pentacycloundecanylamine (Pcu)-Chloroquine Conjugates As
- Reversed Chloroquines
- Quinoline Dimers as Chloroquine-Resistance Reversal Agents
- Dibenzylmethylamine-4-Amino-7-Chloroquinoline (Dibemethin) as Reversed
- Chloroquines
- Dibenzosuberanylpiperazine Derivatives as Chloroquine-Resistance Reversal Agents 42
- Carboxamide and Aminoquinoline-Carboxamide as Drug-Resistance Reversal
- Agents Targeting Abci3
- Chlorpheniramine and Its Analogues as Chloroquine-Resistance Reversal Agents
- Xanthene Derivatives as Chloroquine-Resistance Reversal Agents
- Nonylphenolethoxylates (Npes) as Chloroquine-Resistance Reversal Agents
- Combination of Prochlorperazine and Chloroquine as a Chloroquine-Resistance
- Reversal Strategy
- Structure Activity Relationship Studies of Quinoline Drug-Resistance Reversal Agents 47
- Natural Products Derived Drug-Resistance Reversal Agents
- Natural Products from Artemisia Annua as Chloroquine-Resistance Reversal Agents 48
- Bisbenzylisoquinoline (Bbiq) Alkaloids from Plants as Chloroquine-Resistance
- Reversal Agents
- Pavine-Benzyltetrahydroisoquinolines (Pavine-Btiq) Dimers from Hernandia
- Voyronii as Chloroquine-Resistance Reversal Agents
- Compounds from the Strychnos Genus as Chloroquine-Resistance Reversal Agents 53
- Indole Alkaloids as Chloroquine-Resistance Reversal Agents
- Pregnanes as Natural Products With Chloroquine-Resistance Reversal Agents
- Reversal Activities of Coumarins, Diterpenoids and Xanthones from Plants
- Resistance Reversal Activities of Crude Plant Extracts
- Future Perspectives and Concluding Remarks
- Acknowledgements
- References
- Gloria G. Guerrero M. Juan Manuel Favela-H, Bryan A. Espinoza R. Isaias Balderas
- R. And Jose Olivares T.
- Introduction
- Mechanism of Action of the Anti-Infective Drugs
- Omics Technologies in Drug Discovery
- Genomics and Metagenomics
- Metagenomics
- Transcriptomics
- Transcriptomic Technologies
- Transcriptomics Applied to the Drug Discovery of Anti-Infective Agents
- Identification of New Strategies/Targets for Anti-Infective Drug Design
- Classification of Mechanism of Action (Moa) Through Transcriptomics-Based Workflows 90
- Transcriptomic Workflows Aimed at Generating New Combinations of Existing Drugs
- Proteomics and Metabolomics
- Separation of Proteins by Charge and Molecular Weight
- Detection of Post-Translational Modification Ptm
- Analysis of Lysine- Acetylated Proteins in V. Vulnificus
- Isolation of Proteins Related to Multidrug Resistance
- Metabolomics
- Spectroscopic Techniques Applied to Determine the Chemical Profile of Bioactive
- Metabolites Produced by Bacteria and or Animals (Including Humans)
- Highlights and Perspectives/Conclusion
- References
- Sevgi Akarsu and Fatma Polat
- Introduction
- Hepatitis B Virus Vaccine
- Mumps, Measles, Rubella Vaccine
- Diphtheria, Tetanus, Pertussis, and Polio Vaccines
- Bacillus Calmette-Guérin Vaccine
- Pneumococcal Conjugate Vaccine
- Meningococcal Vaccines
- Varicella Zoster / Herpes Zoster Vaccine
- Influenza Vaccine
- Human Papillomavirus Vaccine
- COVID-19 Vaccine
- Discussion
- Conclusion
- References
- Subject Index
Author
- M. Iqbal Chaudhary
