Precision Medicine and Human Health covers several aspects of precision medicine in 20 edited reviews by researchers and healthcare professionals. The breadth of information provided by the contributors aims to familiarize readers with basic and applied research in personalized therapy.
Starting with an overview of the subject and its relationship with epigenetics, the book progresses into advanced topics that explain its wider applications. The use of precision medicine in treating different diseases such as protein misfolding disorders, gut ulcers and their effect on the gut microbiome, cancer treatment (for hepatocellular carcinoma, breast cancer, and oral cancer), fibromyalgia, high altitude sickness, and multiple sclerosis is explained. The book also covers modern therapeutic techniques to administer personalized therapy, including epithelial-mesenchymal therapy (EMT), circadian clock modulation, and artificial intelligence and phytoconstituents. The next chapters cover advanced technologies that are crucial to precision medicine, such as nanomaterials and advanced drug delivery systems. A concluding chapter on the therapeutic use of tannins in precision medicine rounds up the contents.
Starting with an overview of the subject and its relationship with epigenetics, the book progresses into advanced topics that explain its wider applications. The use of precision medicine in treating different diseases such as protein misfolding disorders, gut ulcers and their effect on the gut microbiome, cancer treatment (for hepatocellular carcinoma, breast cancer, and oral cancer), fibromyalgia, high altitude sickness, and multiple sclerosis is explained. The book also covers modern therapeutic techniques to administer personalized therapy, including epithelial-mesenchymal therapy (EMT), circadian clock modulation, and artificial intelligence and phytoconstituents. The next chapters cover advanced technologies that are crucial to precision medicine, such as nanomaterials and advanced drug delivery systems. A concluding chapter on the therapeutic use of tannins in precision medicine rounds up the contents.
Key Features:
- Features 20 focused chapters contributed by scientific experts
- Introduces readers to basic concepts in precision medicine
- Covers the application of precision medicine in treating different diseases
- Showcases several techniques used in experimental and clinical precision therapy
- Explains modern technologies in precision medicine
- Caters to a wide readership with introductions, structured headings, and references
Readership
Healthcare professionals and scholars who want to learn about basic and applied knowledge in precision medicine.Table of Contents
Chapter 1 Personalized Medicine (Pm) a Critical Appraisal- Origin and Concept of Personalized Medicine (Pm)
- Issues Related to Pm
- Shift the Emphasis in Medicine from Reaction to Prevention Because Prevention is Better
- Than Cure
- Susceptibility Prediction of An Individual to Diseases
- Pre-Empt Disease Progression
- Customization of Strategies for Disease-Prevention
- Prescribe More Effective But Economical Drugs
- Development of Smart Drug Strategies for Patients
- Strict Exclusion of Drugs With Possible Side Effects
- Broad Based Intelligent Clinical Trials With Reduced Time, Cost, and Failure Rate of The
- Pharmaceuticals
- Drug Titration
- Psychosomatic and Spiritual Health
- Civility of the Patients and Their Family Members
- Skill Up-Gradation
- Health and Hygiene
- Advanced Scientific Approach
- Historical Perspective of Pm
- Genetics and Environmental Basis of Disease
- Precision Medicine and Cancer
- Inheritance of Biological Traits
- Status of Pm Across the Globe
- Sub-Disciplines of Pm
- Environment
- Nutrition and Food Habits
- Lifestyle
- Physical Activities and Religious Faith
- Connectivity With Nature
- Patients Diversity and Disease Heterogeneity
- Demography, Epidemiology, Ethnicity and Genome Heterogeneity 19
- Global Adaptation of Pm
- Current Health Care System and Its Management
- Evidence Based Medicine
- Underpinnings of Targeted Therapy
- the Pharmacogenetic Evolution
- Future Prospects of Pm
- Concluding Remarks
- Acknowledgment
- References
- Epigenetic Alterations of the Human Genome
- Prospect of Epigenetic Biomarkers
- Epigenetics and Personalized Medicine
- Bioinformatics and Genomics in Personalized Medicine
- Bioinformatics Challenges for Personalized Medicine
- Processing Large-Scale Genomic Data
- Analysis of the Functional Impact and the Effects of Genetic Variation
- Bringing Systems and Data Together to Capture Biological Complexity
- Interpreting the Data With Proper Clinical Relevance
- Epigenetics and Dna Methylation Aging Clocks
- Conclusion
- Acknowledgements
- References
- Deepti Singh, Mohammad Afsar Khan and Hifzur R. Siddique
- Introduction
- Therapeutic Approaches Effectively Managing Hepatocellular
- Carcinoma (Hcc)
- First-Line Systemic Treatments for Advanced Hcc Management
- Sorafenib, a Multikinase Inhibitor
- Lenvatinib
- Second-Line Treatments for Advanced-Stage Hcc Management
- Regorafenib
- Cabozantinib
- Ramucirumab
- Immune Checkpoint Inhibitors
- Combination of Molecular Targeted Therapies
- a Proof of Concept for Precision Medicine
- Met-Rtk
- the Fgf19-Fgfr4 Axis
- Intracellular Kinases: Mtor
- Immunotherapeutic Approaches: Future of Precision Medicine
- Concluding Remarks
- Abbreviations
- Acknowledgments
- Funding
- References
- Sadia Malik, Sumbul Yasmeen and Rizwan Hasan Khan
- Introduction
- Protein Folding, Misfolding and Aggregation
- Causative Agents of Pmds and Cellular Mechanism of Toxicity
- Structural Features of Amyloid Fibrils and Oligomers
- Mechanism of Amyloid Formation
- Functional Amyloids
- Induction Factors Causing Aggregation
- Analytical Techniques for Detection of Aggregation
- Spectroscopic Methods
- Separation Methods
- Molecular Probes for Characterization of Aggregate
- Immunochemical Methods: Antibody Dot Blot Assay
- Methods for Assaying Protein Aggregate Secondary Structure
- Techniques for Visualization of Aggregated Species
- Strategies for Halting Protein Aggregation of Therapeutic Compounds
- Conclusion
- Acknowledgments
- References
- Tajalli Ilm Chandel, Ifrah Fareed and Rizwan Hasan Khan
- Introduction
- Dietary Proteins
- Role of Dietary Proteins
- Proteins in the Body
- Its Functions
- Glycation
- Maladies
- Aggregation
- on Pathway Aggregation
- Nucleation Dependent Mechanism
- Aggregates
- Amyloid Fibres
- Oligomer
- Amorphous Aggregates
- Inclusion Bodies
- Neurodegenerative Diseases
- Causes and Remedies
- Alzheimer’S Disease (Ad)
- Parkinson’S Disease (Pd)
- Huntington’S Disease
- Prion Disease
- Cross-Talk Between Misfolded Proteins
- Techniques for Investigation
- Non-Clinical Studies (In Vitro)
- in Eppendorf (Small Tube)
- Turbidity Measurements
- Rayleigh Scattering Measurements
- Circular Dichroism Spectroscopy
- Steady-State Fluorescence Measurements
- Dye Binding Assays
- Transmission Electron Microscopy (Tem)
- Atomic Force Microscopy (Afm)
- in Cell Lines
- Immunocytochemistry
- Western Blotting
- Confocal Microscope
- Clinical Studies (In Vivo)
- Types of the Studied Model
- Human Model
- Future Perspective
- Concluding Remarks
- Acknowledgements
- References
- Navin Kumar
- Introduction
- Bacteriology
- Genome and Genetic Diversity
- Bacterial Colonization and Adherence to Host Cell
- Virulence Factors
- Epidemiology
- Transmission and Prevalence
- Clinical Outcomes of H. Pylori Infection
- Acute and Chronic Gastritis
- Peptic Ulcer Disease
- Intestinal Metaplasia and Gastric Cancer
- Gastric Malt Lymphoma
- H. Pylori and Gut Microbiome
- Diagnosis and Treatment
- Concluding Remarks
- Acknowledgements
- References
- Mir Shahid Maqbool, Loveleena Kour Anand and Fayaz Malik
- Introduction
- Breast Cancer (Bc)
- Incidence and Mortality
- World-Wide Status of Breast Cancer
- National Status of Breast Cancer
- Subtypes of Bc
- Luminal - A
- Luminal-B
- Her 2 Enrichment
- Triple Negative Breast Cancer (Tnbc)
- Variation in Diagnostic and Therapeutic Interventions in Tnbc
- Current Therapeutic Approaches for Tnbc
- Focused Therapy for Tnbc Recently Granted by the Fda
- Therapies That Block Immune Check Points
- Poly Adp-Ribose Polymerase (Parp) Inhibitors
- Anti-Trop2 Antibody Drug Conjugate Therapy in Tnbc
- Future Therapeutic Approaches for Triple Negative Breast
- Cancer
Author
- Farzana Mahdi
- Abbas Ali Mahdi
