Topical Dermal Drug Delivery: Concepts and Advances compiles, in a single volume, the most recent advances in topical and dermal formulations for the treatment of skin disorders. The book covers three major concepts. The skin anatomy and physiology part includes chapters focused on relevant information for drug delivery. The second part of the book deals with several recent topical dermal drug delivery systems, including computational methods, permeation enhancers, bio precursors, hydrogels, emugels, exosomes and several nanotechnology enabled systems. The third and final part covers scaling up, toxicity, clinical trials, and regulatory considerations. This is a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the skin. Medical & Health Sciences researchers would also benefit from understanding the delivery systems covered in this book.
Table of Contents
1. Anatomy, Physiology and Immunology of Skin: What to know? 2. An Introduction to Skin diseases: Pathology and Therapeutics 3. Topical dermal drug delivery systems: Conceptualization and advancements 4. Dermatopharmacokinetic: Assessment tools for topically applied dosage forms 5. Artificial Intelligence, Machine learning, and Pharmacoinformatics: A headway to topical dermal drug delivery 6. Permeation enhancers for topical dermal drug delivery 7. Film forming topical dermal drug delivery systems: Basics and advances 8. Prodrug and bioprecursors for topical dermal dug delivery 9. Hydrogels and self-healing hydrogels for topical dermal drug delivery: Journey from bench to market 10. Emulgel: An integrated novel drug delivery system 11. Liposomes as topical dermal drug delivery systems: Lab to bedside 12. Niosomes for topical dermal drug delivery: Preclinical and clinical milestones 13. Transfersomes for topical dermal drug delivery: A matchless carrier 14. Polymersomes for topical dermal drug delivery: Basic views and advancements. 15. Phytosomes for topical dermal drug delivery: Concept and advances 16. Exosomes for topical dermal drug delivery: Recent progress and future Perspectives 17. Polymeric micelles for topical dermal drug delivery: Design, synthesis and applications 18. Lipid nanoparticles for topical dermal drug delivery: Preclinical and clinical advances 19. Polymeric nanoparticles for topical dermal drug delivery: Design and applications 20. Polymeric microparticles for topical dermal drug delivery 21. Dendrimers for topical dermal drug delivery: Recent progress 22. Non-invasive approaches for skin delivery 23. RNA therapeutics for topical dermal drug delivery: From bench to benchside 24. Topical immunization for skin disorders 25. Toxicological considerations of novel topical dermal drug delivery systems 26. Scale up and clinical translation of topical dermal drug delivery products 27. Regulatory framework for development of novel topical dermal drug delivery systems
Authors
Jitender Madan Associate Professor, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India. Dr. Madan's major areas of research include Self-assembled Supramolecular systems viz. liposomes, niosomes, cyclodextrin, nano- & micro-particles and solid-lipid nanoparticles. The focus is centered onto the exploitation of US FDA approved biomaterials in combination with other potential lipids and polymers to develop the innovative dosage forms and drug delivery systems in order to improve the bioavailability, stability, safety (tolerance) and patient-compliance.Whilst a wide range of applications are being taken up, the special emphasis is given to augment the aqueous solubility and bioavailability of lipophilic drugs. Tathagata Dutta Chief Technology Officer, Jodas Expoim Private Limited, Hyderabad, Telangana, India. Dr. Tathagata Dutta has earned his M.Pharm and PhD in Pharmaceutical Sciences from Dr. Hari Singh Gour University, Sagar and completed his postdoctoral studies from School of Pharmacy & Diamantina Institute for cancer, Immunology and Metabolic Medicine, University of Queensland, Brisbane, Australia and was engaged in development of RNAi therapeutics for effective management of cancer. He has served as Chief Scientific Officer (CSO), Vice President (R&D), Executive Director, Managing Director & CEO of several reputed Multinational Pharmaceutical Companies for more than two decades. He is the editorial board member of several international journals on drug discovery & delivery research. His research interests include novel drug delivery systems, dendrimers, liposomes, polymer bioconjugates, tissue targeted drug delivery systems, nano drug delivery systems, gene therapy, genetic immunization, depot injections, gene delivery, and development of RNAi therapeutics. Presently, he is the Chief Technology Officer (CTO) of JODAS EXPOIM Pvt Ltd. Rupinder Kaur Sodhi Professor, Department of Pharmacology, Chandigarh College of Pharmacy, Mohali, Punjab, India. Dr. Sodhi has a doctorate in pharmacology with more than 14 years of experience in guiding the postgraduate students for scientific projects in an academic setting. While teaching, he strongly emphasizes the use of bioinformatics tools for literature survey, formulation
of hypothesis, and guide students to publish their research work in peer reviewed journals. I am also delivering lessons to postgraduate students in drug evaluation
techniques and animal models used in experimental pharmacology.
He is a Coordinator/ Member Secretary for Institutional animal's ethical committee (IAEC) for the conduct of the meetings for the approval of experimental animals. He is actively engaged in maintaining the animal house facilities per the norms. Ravi Shankar Pandey Assistant Professor, Institute of Pharmacy, Guru Ghasidas University, Bilaspur, Chattisgarh, India. Dr. Pandey has a PhD from Dr. Harisingh Gour University, and a Masters degree from the same institution. Ramesh Chandra Vice-Chancellor, Maharaja Surajmal Brij University, Bharatpur, Rajasthan, India. Ramesh Chandra is Vice-Chancellor at Maharaja Surajmal Brij University, Bharatpur, Rajasthan, India.
