The volume provides an introduction to substance P and its pharmacology, followed by exploring its role across the human body including cardiovascular function, micturition, learning and memory, emesis, respiration and sleep. It then discusses the critical role of substance P in several disease states including acute brain injury, neurodegeneration, seizures, depression and anxiety, cancer, musculoskeletal disorders, and viral infection, including COVID-19. The book closes with a look towards future perspectives for substance P.
Substance P: From Pain to Cancer is an ideal reference for researchers across the life sciences interested in understanding the role of this multi-functioning mediator and its biological significance.
Table of Contents
1. The synthesis, release and binding of substance P 2. Distribution of substance P receptors in mammals 3. Substance P in non-mammalian biology: evolutionarily conserved tachykinin signaling 4. Measurement of substance P 5. Substance P antagonists 6. Substance P in the cardiovascular system 7. Substance P in micturition 8. Substance P in learning and memory 9. Substance P in nausea and vomiting 10. Substance P in the central control of respiration 11. Substance P in bone metabolism 12. Life without substance P the naked mole rat 13. Substance P in inflammation 14. Substance P in oxidative stress 15. Substance P In Pain 16. Substance P in cancer 17. Substance P in cardiac dysfunction 18. Substance P in neurotrauma 19. Substance P in stroke 20. Substance P in Alzheimer's and Parkinson's disease 21. Substance P in depression 22. From antidepressants to ADHD via NK1 receptors 23. Substance P in stress and anxiety 24. Substance P in musculoskeletal disorders 25. Substance P in sudden infant death syn 26. Immunology and immuno-pharmacology of Substance P 27. Substance P in viral infection including COVID-19 28. Substance P: Future directions and perspectives
Authors
Robert Vink Consultant (Biotechnology, Legal, Higher Education) Vink NeuroConsulting, Mylor, Australia. Robert Vink is an Emeritus Professor at the University of South Australia and is currently Chair of the Board for Connectivity: Traumatic Brain Injury Australia. He was previously appointed as the Professor and Chair of Neurosurgical Research and Head of School, Medical Sciences at the University of Adelaide, Australia. Throughout his time as a teaching/research academic he led a highly productive research group and maintained an extensive publication output. He is the author of over 260 articles and book chapters. He has supervised more than 30 graduate research students, many of whom now hold significant academic and other positions throughout Australia and internationally.He is known internationally for his work in traumatic brain injury and has received numerous prestigious awards and appointments related to this. He currently provides research consulting services to universities and the pharmaceutical industry.
