This book provides a compressive overview of nanotechnology in modern drug discovery for students and researchers. The book starts with the fundamentals of nanotechnology followed by nanomaterials in pharmaceutical drug design, drug delivery applications, regulatory aspects, formulation and nanoparticle biotransformation. It provides a step by step guide through the drug development process while conveying information about the benefits of nanomaterials for therapy. The book concludes with perspective on the future of nanotechnology-based drug discovery, summarizing current knowledge on nanotherapeutics and translational medicine.
Key Features
- Explains the fundamentals of nanotechnology in drug discovery
- Includes up-to-date information on modern nanopharmaceuticals manufacturing, nanomaterials, and nanoparticle-based drug therapy
- Practice questions for learners and a list of references for advanced readers for each chapter
Readership
Students and researchers in pharmacology and pharmaceutical manufacturing programs.
Table of Contents
Chapter 1 Fundamentals of Nanotechnology
1. Introduction to Nanomaterials
1.1. Changes in Thermal Properties
1.2. Changes in Optical Properties
1.3. Changes in Electronic Properties
1.4. Changes in Electrical Properties
1.5. Changes in Magnetic Properties
1.6. Changes in Chemical Properties
2. Synthesis and Characterization Methods of Nanomaterials
2.1. Bottom-Up Synthesis Methods
2.1.1. Chemical Vapour Deposition
2.1.2. Physical Vapour Deposition
2.1.3. Thermal Decomposition
2.1.4. Chemical Reduction
2.1.5. Photo-Reduction
2.1.6. Biological Synthesis
2.1.7. Solvothermal
2.1.8. Sol-Gel
2.1.9. Co-Precipitation
2.2. Top-Down Synthesis Methods
2.2.1. Mechanical Ball Milling
2.2.2. Nanolithography
2.2.3. Laser Ablation
2.2.4. Electrospinning
2.3. Characterisation of Nanomaterials
3. Nanodevices
3.1. Atomic Force Microscopy
3.2. Nanoarrays/Nanochips
3.3. Nanofluidics
3.4. Nano Biosensors
3.5. Nanobiopsy
4. Advantages of Employing Nanomaterials and Nanodevices In Drug Discovery
5. Challenges and Opportunities in Nanoscale
5.1. Challenges
5.2. Opportunities
- Conclusion
- Practice Questions
- References
Chapter 2 Nanotechnology in Drug Development
1. Introduction
2. Nanotechnology in Drug Target Identification
3. Nanotechnology in Lead Identification and Lead Optimization
4. Nanomaterials in Active Pharmaceutical Ingredient (API) Development
4.1. Nanomaterials in the Synthesis of Api
4.2. Nanomaterials in Api Formulation
- Conclusion
- Practice Questions
- References
Chapter 3 Development of Nanomaterials as Drug Candidates
1. Introduction
2. Dendrimers
3. Carbon-Based Nanoparticles
3.1. Carbon Nanotubes
3.2. Fullerenes
3.3. Graphene Oxide and Derivatives
3.4. Carbon Quantum Dots
4. Nanohydrogel
5. Peptide Nanostructures
6. Mxenes
7. Silicene
8. Antimonene
- Conclusion
- Practice Questions
- References
Chapter 4 Nanotechnology for Drug Design and Drug Delivery
1. Introduction
2. Attributes of An Effective Delivery System
3. Up-To-Date Drug Delivery Systems
3.1. Liposomes
3.2. Polymeric Micelles
3.3. Nanogels
3.4. Nanoemulsions
3.5. Solid Lipid Nanoparticles
3.6. Dendrimers
3.7. Inorganic Nanoparticles
3.8. Electrospun Polymeric Nanofiber
- Conclusion
- Practice Questions
- References
Chapter 5 Fate of Nanoparticles
1. Introduction
2. Cell Uptake and Metabolism
2.1. Endocytosis
2.1.1. Clathrin-Mediated Endocytosis
2.1.2. Caveolin-Dependent Endocytosis
2.1.3. Clathrin and Caveolin-Independent Endocytosis
2.1.4. Phagocytosis
2.1.5. Macropinocytosis
2.2. Direct Fusion With the Plasma Membrane
2.2.1. Cytoplasmic Entry by Direct Translocation
2.2.2. Cytoplasmic Entry by Lipid Fusion
2.2.3. Electroporation
3. In-vivo and In-Vitro Toxicity
- Conclusion
- Practice Questions
- References
Chapter 6 Regulation, Development, and Commercialization of Nano-Based Drugs
1. Introduction
- Conclusion
- References
Chapter 7 Future of Nanotechnology-Based Drug Discovery
1. Introduction
2. Future of Nanotechnology in Disease Diagnosis and Therapy
3. Patient Follow-Up After Treatments
4. Nanotechnology in Overcoming Cancer Drug Resistance
5. Translation of Nanomedicine into Solid Dosages
- Conclusion
- References
- Subject Index
Author
- Laksiri Weerasinghe
- Imalka Munaweera
- Senuri Kumarage
