Upstream Bioprocessing Global Market Report 2024

The upstream bioprocessing market size has grown rapidly in recent years. It will grow from $10.63 billion in 2023 to $12.03 billion in 2024 at a compound annual growth rate (CAGR) of 13.1%. The growth in the historic period can be attributed to the increased need for process optimization and contamination-free, safe, and efficient production of biomolecules, commercial success, and rising demand for biotherapeutics. Additionally, there was a rise in the implementation of process analytical technology, an increase in chronic disease prevalence, and heightened research into the production of biosimilars.

The upstream bioprocessing market size is expected to see rapid growth in the next few years. It will grow to $19.84 billion in 2028 at a compound annual growth rate (CAGR) of 13.3%. The growth in the forecast period can be attributed to the commercial use of single-use bioreactors, the outsourcing of biopharmaceutical manufacturing, the rapid growth of the pharmaceutical and biotechnology industries, the rising adoption of single-use upstream bioprocessing, and increasing partnerships, mergers, acquisitions, and collaborations. Major trends in the forecast period include increasing investments in R&D in the biopharmaceutical industry, technological advancements, advanced upstream bioprocessing technologies, the development of new technologies, and advanced filtration technologies.

The growth of the upstream bioprocessing market is expected to be propelled by the outsourcing of biopharmaceutical manufacturing. This outsourcing involves delegating certain production stages to external entities such as contract manufacturing organizations (CMOs) or contract development and manufacturing organizations (CDMOs). It is driven by factors such as cost efficiency, focus on core competencies, flexibility in production scaling, access to specialized expertise, and risk mitigation. Outsourcing biopharmaceutical manufacturing accelerates product development by leveraging external expertise, streamlining operations, and reducing costs. For instance, BDO USA predicts that by 2025, contract development and manufacturing organizations along with hybrid manufacturing companies will control 44% of the global mammalian capacity of around 7,500kL. Hence, the outsourcing of biopharmaceutical manufacturing is a key driver of the upstream bioprocessing market's growth.

Leading companies in the upstream bioprocessing market are concentrating on developing advanced bioreactors tailored to cell culture processes, enhancing performance, flexibility, and scalability. Bioreactors are crucial tools in upstream bioprocessing, enabling efficient and controlled biopharmaceutical production through cell culture and biomolecule manufacturing. For example, in April 2023, Cytiva introduced X-platform bioreactors designed to streamline single-use upstream bioprocessing procedures. These bioreactors feature a modular design consisting of a tank, cabinet assembly, and human-machine interface (HMI), allowing flexible arrangements without the need for custom hardware or single-use bags. User-friendly features include an optimized vessel with a full-opening door, baffles, and improved cable management. Additionally, the online Bioreactor Scaler tool aids in determining optimal parameters for successful scale-up.

In May 2022, Lonza entered into a license agreement with Adva Biotechnology, granting Adva access to key intellectual property for the global expansion of automated bioreactors. This agreement provides Adva Biotechnology with a non-exclusive license to specific patents in Lonza's portfolio related to smart automation and bioreactor control. Adva Biotechnology, based in Israel, is focused on developing innovative technologies for upstream bioprocessing in the cell therapy industry.

Major companies operating in the upstream bioprocessing market are Thermo Fisher Scientific Inc., Danaher Corp, Merck KGaA, GE HealthCare Technologies, Parker Hannifin Corp, Corning Inc., AGC Biologics, Avantor, AGC Inc., Boehringer Ingelheim International GmbH, Catalent Inc., Sartorius AG, Entegris Inc., Getinge AB, Bio-Rad Laboratories Inc., Samsung Biologics Co. Ltd., Eppendorf AG, Repligen Corporation, Takara Bio Inc., KBI Biopharma Inc., Rentschler Biopharma SE, Just Biotherapeutics Inc., PBS Biotech Inc., Stobbe Group, Applikon Biotechnology.

North America was the largest region in the upstream bioprocessing market in 2023. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the upstream bioprocessing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

The countries covered in the upstream bioprocessing market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Upstream bioprocessing involves preparing and cultivating cells to produce biological products such as proteins and vaccines. It focuses on cell line development and cell culture to create a scalable system that maximizes yield and quality, ensuring reproducibility and efficiency for downstream purification and formulation.

The primary products of upstream bioprocessing include bioreactors, fermenters, cell culture media, filters, and bags and containers. Bioreactors are vessels or tanks where biological reactions and processes occur under controlled conditions. The workflow includes media preparation, cell culture, and cell separation, with usage options including single-use and multi-use systems. These processes can be performed in-house or outsourced by various end users such as contract development and manufacturing organizations (CDMOs), contract research organizations (CROs), research and academic institutes, and biopharmaceutical companies.

The upstream bioprocessing market research report is one of a series of new reports that provides upstream bioprocessing market statistics, including upstream bioprocessing industry global market size, regional shares, competitors with a upstream bioprocessing market share, detailed upstream bioprocessing market segments, market trends and opportunities, and any further data you may need to thrive in the upstream bioprocessing industry. This upstream bioprocessing market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

The upstream bioprocessing market consists of revenues earned by entities by providing services such as cell line development, inoculum preparation, process development and optimization, scale-up production, quality control and monitoring and raw material supply and management. The market value includes the value of related goods sold by the service provider or included within the service offering. The upstream bioprocessing market also includes sales of recombinant proteins, monoclonal antibodies, vaccines, gene therapy vectors, cell therapy products, enzymes, peptides, bio therapeutics and biosimilars. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.


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