This inter-disciplinary volume provides information on anticancer medicines derived from marine organisms. Eight edited reviews extensively list the variety of organisms including marine plants, sponges, cnidarians and fish. Emphasis is placed on the source of the compounds, their structure and mechanism of action. Anticancer peptides from sponges are covered in a dedicated chapter. The specific biology and ecology of marine organisms yielding these anticancer compounds is also highlighted where appropriate. All chapters include detailed references for advanced readers.
This volume is a standard text-cum-reference for teachers, students and researchers of various disciplines such as Biomedical Sciences, Pharmaceutical Sciences, Marine Biology, and Fisheries Science, it also serves as a guide to marine anticancer compounds for professionals in the pharmaceutical industry who are involved in the development of new marine-derived anticancer drugs.
This volume is a standard text-cum-reference for teachers, students and researchers of various disciplines such as Biomedical Sciences, Pharmaceutical Sciences, Marine Biology, and Fisheries Science, it also serves as a guide to marine anticancer compounds for professionals in the pharmaceutical industry who are involved in the development of new marine-derived anticancer drugs.
Readership:
Academics and scholars in Biomedical Sciences, Pharmaceutical Sciences, Marine Biology, and Fisheries Science; professionals in the pharmaceutical industry who are involved in the development of new marine-derived anticancer drugs.Table of Contents
FOREWORD- PREFACE
- INTRODUCTION
- Approved Drugs Sourced from Marine Biota
- Cancer as a Major Public Health Problem
- Pathophysiology of Cancer
- Anticancer Potential of Marine Organisms
- Most Promising Marine Biota-Derived Anticancer Compounds for the Different Types of
- Human Cancer
- Human Colon Cancer
- Human Cervical Cancer
- Blood Cancer
- Mammary Cancer
- Hepatic Cancer
- Human Skin Cancer
- Biogeography of Marine Invertebrate Species Yielding Anticancer Compounds
- Major Constraints in the Development of Anticancer Drugs
- CONCLUSION
- GROUPS
- INTRODUCTION
- Promising Anticancer Marine Biodiversity
- Marine Microalgae
- Macroalgae (Seaweeds)
- Mangrove Plants
- Marine Invertebrates
- Promising Anticancer Marine Biota-derived Chemical Diversity
- Predicted Total Number of Secondary Metabolites in Marine Plants and Invertebrates
- Anticancer Marine Chemical Classes
- Polyphenols
- Polysaccharides
- Alkaloids
- Peptides
- Antibiotics
- Anticancer Chemical Diversity of Marine Biota
- CONCLUSION
- INTRODUCTION
- APPROVED AND MARKETED ANTICANCER DRUGS DERIVED FROM MARINE
- SPONGES
- Eribulin Mesylate (E7389, Halaven®)
- Panobinostat (LBH-589, Farydak®)
- APPROVED AND MARKETED ANTICANCER DRUGS DERIVED FROM MARINE
- MOLLUSKS/CYANOBACTERIA ASSOCIATION
- Brentuximab Vedotin ((SGN-35, Adcetris®)
- Polatuzumab Vedotin
- Enfortumab Vedotin-Eifv (Padcev®)
- Disitamab Vedotin
- Tisotumab Vedotin-tftv (Tivdak®)
- Belantamab Mafodotin-blmf (Blenrep®)
- APPROVED AND MARKETED ANTICANCER DRUGS DERIVED FROM MARINE
- TUNICATES
- Plitidepsin (Aplidin®)
- Trabectedin (Yondelis®)
- Lurbinectedin
- MARINE BIOTA- DERIVED ANTICANCER COMPOUNDS IN CLINICAL TRIALS
- ANTICANCER MARINE SPECIES IN CLINICAL TRIALS
- PATENTED NEW CHEMICAL ENTITIES (NCES) WITH ANTICANCER ACTIVITIES
- FROM MARINE BIOTA
- Limiting Factors in the Development and Approval of Drugs from Marine Biota
- Significant Challenges in the Development and Approval of Marine Drugs
- CONCLUSION
- INTRODUCTION
- Microalgae
- Green Algae
- Chlorella sp.
- Dunaliella tertiolecta
- BLUE-GREEN ALGAE
- Anabaena sp.
- Arthrospira platensis (= Spirulina platensis)
- Calothrix sp.
- Coleofasciculus sp.
- Cyanobium sp.
- Dapis sp.
- Leptolyngbya halophila
- Leptolyngbya mycoidea
- Leptolyngbya fragilis
- Leptolyngbya sp.
- Leptothoe kymatousa , Leptothoe sithoniana and Leptothoe spongobia
- Nodosilinea nodulosa
- Lyngbya majuscula
- Lyngbya polychroa
- Lyngbya sp.
- Microcystis aeruginosa
- Moorea bouillonii (= Lyngbya boulloni)
- Moorea producens
- Nodularia spumigena
- Nodularia sp. LEGE 06071
- Nostoc commune
- Nostoc linckia
- Nostoc linckia and Nostoc spongioforme
- Nostoc sp.
- Nodosilinea nodulosa LEGE 06102
- Okeania hirsuta
- Okeania sp.
- Phormidium sp.
- Pseudanabaena curta
- Pseudanabaena sp. LEGE 06144
- Romeria gracilis
- Schizothrix calcicola
- Schizothrix sp.
- Symploca hydnoides
- Symploca sp.
- Synechocystis salina
- Synechocystis sp. PCC 6803
- Synechococcus sp.
- Golden-brown, and Yellow Algae
- Isochrysis galbana
- Prymnesium parvum
- Yellow-Green Algae (Diatoms)
- Chaetoceros simplex var. calcitrans ( = Chaetoceros calcitrans)
- Cocconeis scutellum
- Cylindrotheca closterium
- Haslea karadagensis
- Navicula salinicola ( = Navicula incerta)
- Odontella aurita
- Phaeodactylum tricornutum
- Pseudo-nitzschia delicatissima
- Skeletonema costatum
- Skeletonema marinoi
- Synedra acus
- Thalassionema nitzschioides
- Thalassiosira rotula
- Thalassiosira rotula, Skeletonema costatum and Pseudo-nitzschia delicatissima
- Vibrio ostrearius ( = Haslea ostrearia)
- Dinoflagellates
- Alexandrium andersoni
- Alexandrium pseudogonyaulax ( = Goniodoma pseudogoniaulax) Alexandrium
- monilatum and Alexandrium hiranoi
- Alexandrium minutum
- Alexandrium ostenfeldii
- Alexandrium peruvianum
- Amphidinium carterae
- Amphidinium operculatum AA60
- Amphidiniumsp. S1-36-5
- Amphidinium sp. 12012-7-4A
- Amphidiniumsp. 1
- Amphidinium sp. 2
- Amphidinium sp. 3
- Amphidinium sp. 5
- Amphidinium sp. 7
- Alexandrium tamarense
- Azadinium sp.
- Cripthecodinium chonii
- Dinophysis acuminata
- Dinophysis acuta
- Dinophysis caudata
- Dinophysis fortii, Dinophysis miles, Dinophysis norvegica, Dinophysis rotundataum
- and Dinophysis sacculus
- Dinophysis tripos
- Gambierdiscus australes
- Gambierdiscus pacificus and Gambierdiscus toxicus
- Gambierdiscus toxicus
- Gonyaulax spinifera
- Heterocapsa circularisquama
- Heterocapsa triquetra
- Karlodinium veneficum
- Karenia mikimotoi ( = Gymnodinium mikimotoi)
- Karenia selliformis ( = Gymnodinium selliforme)
- Ostreopsis fattorussoi
- Ostreopsis ovata
- Ostreopsis siamensis
- Phalacroma mitra ( = Dinophysis mitra) and Phalacroma rotundatum ( = Dinophysis
- rotundata)
- Prorocentrum arenarium
- Prorocentrum hoffmannianum ( = Prorocentrum belezeanum; Prorocentrum
- maculosum)
- Prorocentrum concavum and Prorocentrum lima
- Prorocentrum reticulatum
- Symbiodinium sp.
- Vulcanodinium rugosum
- Red alga
- Porphyridium cruentum ( = Porphyridium purpureum)
- Macroalgae (Seaweeds)
- Green algae
- Brown algae
- Fucus vesiculosus, Laminaria japonica, Alaria esculenta, Ascophyllum nodosum,
- Bifurcaria bifurcata and Sargassum muticum and Bifurcaria bifurcata
- Carpodesmia tamariscifolia ( = Cystoseira tamariscifolia)
- Colpomenia sinuosa and Sargassum prismaticum
- Eisenia bicyclis
- Ecklonia cava
- Fucus vesiculosus
- Ishige okamurae
- Laminaria digitata
- Laminaria japonica
- Sargassum carpophyllum
- Sargassum filipendula
- Sargassum hemiphyllum
- Sargassum sp.
- Stypodium zonale
- Undaria pinnatifida
- Red algae
- Amphiroa anceps
- Champia feldmanni
- Champia parvula
- Chondrus armatus
