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Yarrowia Lipolytica Yeast. From Metabolic Engineering to Biotechnological Applications

  • Book

  • February 2025
  • Elsevier Science and Technology
  • ID: 5994660

Yarrowia Lipolytica Yeast: From Metabolic Engineering to Biotechnological Applications gathers all the information about the genetics, uses, extraction, purification, and applications of this non-conventional yeast, not just focusing on the genetics and metabolic engineering, nor on its biotechnological applications. Chapters cover the genetic modifications and techniques used to genetically modify Y. Lipolytica, fermentation conditions, various media used in biotechnological applications, and all value-added compounds that can be produced. Edited by the most renowned researchers of this yeast, this book is of great interest to industries t working on biofuel production or searching for environmentally-friendly, natural alternatives for their chemically produced value-added compounds.

Table of Contents

1. Overview of Yarrowia lipolytica (History, Taxonomy, Characteristics, Reproduction)
2. Genetic tools used for engineering Yarrowia lipolytica
3. Metabolic engineering of Yarrowia lipolytica for the production of proteins (Lipases, Esterases, Proteases, Phosphatases, RNase, etc.)
4. Metabolic engineering of Yarrowia lipolytica for the production of organic acids (Citric and isocitric acids, Alpha-ketoglutaric acid, Pyruvic acid, Succinic acid, etc.)
5. Metabolic engineering of Yarrowia lipolytica for the production of fatty acids
6. Metabolic engineering of Yarrowia lipolytica for the production of aromatic compounds (?-decalactone, 2-phenylethanol, violacein, deoxyviolacein, resveratrol, etc.)
7. Synthetic media, agro-industrial by-products, and culture conditions used in biotechnological applications
8. Cell disruption technologies for the extraction of the natural added-value compounds
9. Purification techniques of different metabolites (using membrane contactors, chromatographic techniques, membrane-based technique)
10. Industrial applications of Yarrowia lipolytica

Authors

Mohamed Koubaa Assistant Professor, Ecole Superieure de Chimie Organique et Minerale, Compiegne, France. Dr. Koubaa is a researcher and assistant professor in Process Engineering at the School of Organic and Mineral Chemistry (Compi�gne, France). He carried out various postdoctoral research stays at the University of Technology of Compi�gne (Compi�gne, France), at the University of the State of Ohio (Columbus, Ohio, United States), and at the National School of 'Engineers of Sfax (Sfax, Tunisia). His research mainly focuses on the treatment of plant and microbial biomass by emerging technologies (pulsed electric fields, ultrasound, etc.) for the extraction of compounds of interest, and the improvement of fermentation and preservation conditions. He has more than 90 publications (book, book chapters and scientific articles in peer-reviewed international journals). Sara Mitri PhD candidate, Process Engineering, University of Technology of Compiegne, France. Dr. Mitri, PhD in Computer and Communication Sciences from the Ecole Polytechnique F�d�rale de Lausanne (EPFL), Switzerland, was a postdoctoral fellow at the AS Center for Systems Biology, Harvard University, USA; and also in the Department of Zoology, University of Oxford, UK. Her research has always been at the intersection between the computational sciences and biological evolution. Currently she is the head of Mitri lab, which focus is on the ecology and evolution of simple microbial communities composed of a handful of species in the lab. Dr. Mitri is also tenure-track Assistant Professor at the Department of Fundamental Microbiology, at the University of Lausanne, Switzerland. She has published in several high impact journals. Nicolas Louka Professor, Saint Joseph University of Beirut, Beyrouth, Lebanon. Dr. Louka is a professor of "Industrial Process Engineering�, director of the "Center for Analysis and Research� and responsible of technologies transfer: University-Industry� at the FS-USJ (Saint Joseph University of Beirut). He is also director of the UR "Technology and Valorization of Agro-resources�, director of the "Doctoral School of Science, Engineering and Technology� at USJ. He obtained his PhD in Industrial Process Engineering from University of Technology of Compi�gne, Sorbonne Universities, France. His research activities focus mainly, through innovative technologies, on extraction, dehydration, texturizing, sterilization, elimination of mycotoxins from foods and in the implementation of a new process for waste treatment. He has more than 200 publications and 19 patents. His experience in the design of industrial pilots and construction of different industries in France, Africa and Lebanon, makes him an expert in the field.