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The Resistance of Cervical Cancer to Chemotherapy and its Reversal. Breaking Tolerance to Anti-Cancer Cell-Mediated Immunotherapy

  • Book

  • February 2025
  • Elsevier Science and Technology
  • ID: 5994679

The Resistance of Cervical Cancer to Chemotherapy and its Reversal provides a holistic understanding of cervical cancer development, immune-evading mechanisms of HPV, immunotherapies available, methods to study cervical cancer and the development of newer drugs. Content shows the involvement of signaling pathways during chemoresistance in cervical cancer, the involvement of genes in drug resistance, and introduces long noncoding RNAs as novel biomarkers. In 10 chapters, this book first provides an introduction and history of cervical cancer; next, it discusses the influence of viruses on cervical cancer and finally, it describes therapies to overcome chemotherapy resistance in cervical cancer. This is the perfect reference to provide the fundamental base of knowledge needed for oncologists, pharmacologists, translational investigators, immunotherapists, scientists, and clinicians interested in building a comprehensive understanding of the field.

Table of Contents

1. Wnt signalling and cervical cancer 2. Pharmacologial targets of cervical cancer 3. PD-1, HPV and cervical cancer 4. Radiotherapy and cervical cancer 5. HPV and cervical cancer 6. EGFR and cervical cancer 7. Protein engineering for cervical cancer 8. Anti-virals and cervical cancer 9. Advances in cytological screening for cervical cancer 10. microRNA and cervical cancer 11. Computer aided drug designing for cervical cancer 12. Nanoparticles for the treatment of cervical cancer

Authors

S. Muthusami Associate Professor and Head, Cancer Research Centre, Karpagam Academy of Higher Education, Coimbatore, India. Dr. Sridhar Muthusami completed his Ph.D in endocrinology in the year 2011 from the University of Madras, India. His doctoral study was aimed at delineating the molecular mechanism underlying the anabolic actions of Cissus quadrangularis, an indigenous herb believed to exert anabolic effects on bone cells through IGFR. After completing his Ph.D, he has joined for his Postdoctoral work in the department of Radiation Oncology, Chungbuk National University, South Korea. He has worked on the role of Epidermal growth factor/receptor (EGF/EGFR) signaling and its regulation of oncoprotein Fused Toes Homolog (FTS) in cervical cancer cells from 2011 to 2014. He is also involved in the identifying the role of T0070907/EGCG/cordycepin on cervical cancer cells. Since 2015, he moved to the department of biochemistry, Karpagam Academy of Higher Education (Deemed to be University) and serving as Associate Professor and Head at Cancer Research Centre working in the area of development of EGFR TKIs for the treatment/management of cervical cancer/pancreatic cancer.