Liquid Chromatography Mass Spectrometry (LC-MS) Market Report 2025

This Liquid Chromatography Mass Spectrometry (LC-MS) market report provides a comprehensive analysis of the market’s characteristics, size, and growth, including segmentation, regional and country-level breakdowns, competitive landscape, market shares, trends, and strategies. It also tracks historical and forecasted market growth across various geographies.

The liquid chromatography mass spectrometry (LC-MS) market size has grown rapidly in recent years. It will grow from $6.82 billion in 2024 to $7.85 billion in 2025 at a compound annual growth rate (CAGR) of 15.1%. The growth in the historic period can be attributed to increasing research and development expenditure, rising application in environmental testing, growing applications in pharmaceutical industry, and increasing demand in pharmaceutical and biotechnology industries, increasing the need for the liquid chromatography mass spectrometry.

The liquid chromatography mass spectrometry (LC-MS) market size is expected to see rapid growth in the next few years. It will grow to $13.57 billion in 2029 at a compound annual growth rate (CAGR) of 14.7%. The growth in the forecast period can be attributed to increasing clinical trials to deliver higher results, growing focus on research and development, increasing air and water pollution, growth in demand for sustainable environmental policies, rising environmental awareness. Major trends in the forecast period include advanced technologies, increasing product and technology innovation, innovative technologies and features, growing focus on research and development, and advancements in metabolomics and proteomics research.

The liquid chromatography-mass spectrometry (LC-MS) market is expected to experience growth driven by the increasing number of clinical trials. Clinical trials involve assessing new medical treatments, interventions, or therapies in humans to gauge their safety and effectiveness. This uptick in clinical trials is spurred by advancements in medical research, the rising incidence of chronic diseases, regulatory backing and incentives, heightened investments in research and development (R&D), and the expansion of precision medicine initiatives. LC-MS plays a crucial role in clinical trials by delivering precise and reliable analyses of biological samples. It facilitates the identification and quantification of drugs, metabolites, and biomarkers, thereby supporting evaluations of drug efficacy and safety, pharmacokinetic and pharmacodynamic studies, and personalized medicine approaches. For instance, data from ClinicalTrials.gov, a US-based clinical trial registry, shows a global increase in registered clinical trials - from 437,512 trials in 2022 to 477,234 trials in 2023. This rise underscores how the growing number of clinical trials is propelling the expansion of the liquid chromatography-mass spectrometry market.

Major companies in the liquid chromatography-mass spectrometry (LC-MS) market are concentrating on advancing innovative products such as high-performance LC-MS instruments. These instruments aim to enhance analytical sensitivity, accuracy, and speed, thereby improving the detection and quantification of complex biological and chemical compounds. High-performance LC-MS instruments represent cutting-edge analytical devices tailored to achieve exceptional sensitivity and precision in identifying and measuring intricate mixtures of compounds. An example of such innovation is seen with Thermo Fisher Scientific, a prominent US-based medical device manufacturer. In June 2024, the company introduced Stellar, a high-performance LC-MS instrument. Stellar is specifically designed for highly multiplexed targeted quantitation, blending rapid throughput, high sensitivity, and user-friendly operation to advance translational omics research and facilitate more efficient breakthrough discoveries.

In February 2022, Agilent Technologies Inc., a leading US-based provider of liquid chromatography-mass spectrometry solutions, acquired artificial intelligence (AI) technology developed by Virtual Control. The acquisition, for an undisclosed amount, includes Virtual Control's ACIES software and associated assets. ACIES is utilized in conjunction with Agilent's LC-MS and GC-MS instruments, aimed at automating data analysis processes to enhance efficiency in laboratory workflows. Virtual Control, headquartered in Hong Kong, specializes in developing software solutions for laboratories, with ACIES specifically tailored for integration with LC-MS systems.

Major companies operating in the liquid chromatography mass spectrometry (LC-MS) market are Hitachi Ltd., Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, Agilent Technologies Inc., VWR International LLC, PerkinElmer Inc., Shimadzu Corporation, Waters Corporation, Bruker, SCIEX, JEOL Ltd., Hamilton Company, GL Sciences Inc., Phenomenex Inc., Analytik Jena GmbH+Co. KG, Gilson Incorporated, Skyray Instruments USA Inc., Advion Inc., JASCO.

North America was the largest region in the liquid chromatography mass spectrometry (LC-MS) market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the liquid chromatography mass spectrometry (LC-MS) market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the liquid chromatography mass spectrometry (LC-MS) market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Liquid chromatography-mass spectrometry (LC-MS) is an analytical method used to separate, identify, and quantify components within mixtures. It merges the separation capabilities of liquid chromatography with the detection and identification abilities of mass spectrometry. LC-MS is widely employed for analyzing intricate samples due to its high sensitivity and specificity. Its primary objective is to offer comprehensive insights into sample composition, aiding researchers and analysts in comprehending its chemical characteristics and attributes.

LC-MS encompasses various types such as normal-phase liquid chromatography (NPLC), reversed-phase liquid chromatography (RPLC), ion exchange liquid chromatography (IELC), size exclusion liquid chromatography (SELC), high-performance liquid chromatography (HPLC), ultra-high pressure liquid chromatography (UHPLC), low-pressure liquid chromatography (LPLC), and others. NPLC involves a polar stationary phase typically made of silica or alumina, paired with a non-polar mobile phase such as hexane or chloroform. These methodologies encompass single mass spectrometry, hybrid mass spectrometry, and other platforms. They find application across diverse sectors including pharmaceuticals, biotechnology, petrochemicals, environmental testing, and food and beverage analysis, serving biotechnological and pharmaceutical industries, research and diagnostic laboratories, as well as governmental and public entities.

The liquid chromatography mass spectrometry market research report is one of a series of new reports that provides liquid chromatography mass spectrometry market statistics, including the liquid chromatography mass spectrometry industry global market size, regional shares, competitors with liquid chromatography mass spectrometry market share, detailed liquid chromatography mass spectrometry market segments, market trends, and opportunities, and any further data you may need to thrive in the liquid chromatography mass spectrometry industry. These liquid chromatography mass spectrometry market research reports deliver a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.

The liquid chromatography mass spectrometry (LC-MS) market consists revenues earned by entities by providing services such as sample preparation, method development and validation, quantitative and qualitative analysis, and biopharmaceutical analysis. The market value includes the value of related goods sold by the service provider or included within the service offering. The liquid chromatography mass spectrometry market also includes sales of LC-MS systems, liquid chromatographs, mass spectrometers, solvents, buffers, columns, and sample prep kits. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

This product will be delivered within 3-5 business days.