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Hepatic Encephalopathy (HE) Treatment - Global Strategic Business Report

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    Report

  • 283 Pages
  • December 2024
  • Region: Global
  • Global Industry Analysts, Inc
  • ID: 5997797
The global market for Hepatic Encephalopathy (HE) Treatment was estimated at US$1.5 Billion in 2023 and is projected to reach US$2.1 Billion by 2030, growing at a CAGR of 4.5% from 2023 to 2030. This comprehensive report provides an in-depth analysis of market trends, drivers, and forecasts, helping you make informed business decisions.

How is Hepatic Encephalopathy Understood and Diagnosed?

Hepatic Encephalopathy (HE) is a complex neuropsychiatric syndrome resulting from liver dysfunction, often seen in patients with chronic liver disease, particularly cirrhosis. The condition manifests with a spectrum of cognitive, psychiatric, and motor abnormalities due to the liver's inability to detoxify the blood. The buildup of toxic substances like ammonia leads to brain dysfunction, ranging from subtle cognitive impairments to deep coma. Diagnosis typically relies on clinical assessment, supported by laboratory tests measuring blood ammonia levels, neuroimaging, and neuropsychological evaluations. However, the nonspecific nature of early symptoms, such as confusion and forgetfulness, can complicate the timely diagnosis of HE. The classification of HE into different grades, from mild (Grade 1) to severe (Grade 4), allows for a structured approach to its management and underscores the need for timely intervention to prevent progression to more severe stages.

What Are the Emerging Treatment Modalities for Hepatic Encephalopathy?

Treatment of Hepatic Encephalopathy focuses on reducing the production and absorption of toxic substances, especially ammonia, in the gut. Standard therapies include non-absorbable disaccharides like lactulose, which acidify the gut and promote the excretion of ammonia, and antibiotics such as rifaximin, which reduce ammonia-producing bacteria. The combination of these treatments has shown to be effective in both the acute management and long-term prevention of HE episodes. In recent years, the exploration of gut microbiota modulation has gained traction, with probiotics and prebiotics being investigated for their potential to alter gut flora favorably. Additionally, advancements in liver support systems and liver transplantation continue to provide options for patients with refractory HE. Novel agents targeting neuroinflammation and oxidative stress are also under investigation, promising to expand the therapeutic arsenal against HE. As research continues, the integration of these emerging therapies into clinical practice may significantly enhance patient outcomes.

Can Nutritional and Lifestyle Modifications Alter the Course of Hepatic Encephalopathy?

Beyond pharmacological interventions, nutritional and lifestyle modifications play a critical role in the management of Hepatic Encephalopathy. Protein restriction, once widely recommended, is now approached with caution, as adequate protein intake is essential to prevent muscle wasting, which can exacerbate HE. Instead, the emphasis has shifted towards the intake of branched-chain amino acids (BCAAs) that are less likely to be metabolized into ammonia. Additionally, maintaining optimal hydration and avoiding factors that exacerbate liver dysfunction, such as alcohol and certain medications, are essential. Patients are also advised to adopt a low-sodium diet to manage ascites and prevent fluid overload. Regular monitoring and timely adjustment of dietary plans, in conjunction with medical therapy, can help manage HE more effectively. Education on recognizing early symptoms and avoiding potential triggers is crucial for both patients and caregivers, ensuring a proactive approach to managing this chronic condition.

What Is Driving the Growth of the Hepatic Encephalopathy Treatment Market?

The growth in the Hepatic Encephalopathy treatment market is driven by several factors, including the increasing prevalence of liver diseases such as cirrhosis, hepatitis, and non-alcoholic fatty liver disease (NAFLD), which are closely linked to the incidence of HE. The rising global burden of these conditions, fueled by lifestyle changes and aging populations, is a significant market driver. Additionally, advancements in diagnostic technologies that allow for earlier and more accurate detection of HE are propelling the demand for effective treatments. The development of novel therapeutics, including those targeting the gut-liver axis and neuroinflammation, is expanding the treatment landscape and attracting substantial investment in research and development. Furthermore, the growing awareness among healthcare professionals and patients about the importance of managing HE proactively is leading to increased adoption of both traditional and innovative treatments. Lastly, favorable regulatory policies and the availability of better healthcare infrastructure, particularly in emerging markets, are contributing to the market's expansion, making advanced HE therapies more accessible to a broader patient population.

Key Insights:

  • Market Growth: Understand the significant growth trajectory of the Antibiotics Treatment segment, which is expected to reach US$785.0 Million by 2030 with a CAGR of a 5.4%. The Laxatives Treatment segment is also set to grow at 4.4% CAGR over the analysis period.
  • Regional Analysis: Gain insights into the U.S. market, which was estimated at $418.4 Million in 2023, and China, forecasted to grow at an impressive 7.6% CAGR to reach $431.2 Million by 2030. Discover growth trends in other key regions, including Japan, Canada, Germany, and the Asia-Pacific.

Why You Should Buy This Report:

  • Detailed Market Analysis: Access a thorough analysis of the Global Hepatic Encephalopathy (HE) Treatment Market, covering all major geographic regions and market segments.
  • Competitive Insights: Get an overview of the competitive landscape, including the market presence of major players across different geographies.
  • Future Trends and Drivers: Understand the key trends and drivers shaping the future of the Global Hepatic Encephalopathy (HE) Treatment Market.
  • Actionable Insights: Benefit from actionable insights that can help you identify new revenue opportunities and make strategic business decisions.

Key Questions Answered:

  • How is the Global Hepatic Encephalopathy (HE) Treatment Market expected to evolve by 2030?
  • What are the main drivers and restraints affecting the market?
  • Which market segments will grow the most over the forecast period?
  • How will market shares for different regions and segments change by 2030?
  • Who are the leading players in the market, and what are their prospects?

Report Features:

  • Comprehensive Market Data: Independent analysis of annual sales and market forecasts in US$ Million from 2023 to 2030.
  • In-Depth Regional Analysis: Detailed insights into key markets, including the U.S., China, Japan, Canada, Europe, Asia-Pacific, Latin America, Middle East, and Africa.
  • Company Profiles: Coverage of major players such as AbbVie Inc.,, ASKA Pharmaceutical Co., Ltd., Bausch Health Companies Inc., and more.
  • Complimentary Updates: Receive free report updates for one year to keep you informed of the latest market developments.

Select Competitors (Total 43 Featured):

  • AbbVie Inc.,
  • ASKA Pharmaceutical Co., Ltd.
  • Bausch Health Companies Inc.
  • Cosmo Pharmaceuticals NV
  • Eisai Co., Ltd.,
  • Hikma Pharmaceuticals PLC
  • Kannalife Sciences, Inc.
  • Lupin Limited
  • Mallinckrodt Pharmaceuticals
  • Merck & Co., Inc.
  • Norgine B.V.
  • Pfizer Inc.
  • Salix Pharmaceuticals, Inc.
  • Takeda Pharmaceutical Company Limited
  • Umecrine Cognition AB

Table of Contents

I. METHODOLOGYII. EXECUTIVE SUMMARY
1. MARKET OVERVIEW
  • Influencer Market Insights
  • Global Economic Update
  • Hepatic Encephalopathy (HE) Treatment - Global Key Competitors Percentage Market Share in 2024 (E)
  • Competitive Market Presence - Strong/Active/Niche/Trivial for Players Worldwide in 2024 (E)
2. FOCUS ON SELECT PLAYERS
3. MARKET TRENDS & DRIVERS
  • Emerging Novel Therapies Drive Market Expansion for Hepatic Encephalopathy Treatment Solutions
  • Rising Global Incidence of Liver Disease and Cirrhosis Significantly Accelerates Demand for HE Interventions
  • Increased Public Health Awareness Campaigns Expand the Addressable Market Opportunity for HE Treatments
  • Integration of Telemedicine in HE Management Solutions Drives Widespread Accessibility of Care
  • Focus on Patient-Centric Approaches Generates Growing Demand for Personalized and Innovative Hepatic Encephalopathy Therapies
  • Biopharmaceutical Innovations in Targeted HE Treatments Open New Avenues for High-Precision Care
  • Introduction of Cost-Effective HE Treatment Options Strengthens Market Penetration
4. GLOBAL MARKET PERSPECTIVE
  • Table 1: World Hepatic Encephalopathy (HE) Treatment Market Analysis of Annual Sales in US$ Thousand for Years 2014 through 2030
  • Table 2: World Recent Past, Current & Future Analysis for Hepatic Encephalopathy (HE) Treatment by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 3: World Historic Review for Hepatic Encephalopathy (HE) Treatment by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 4: World 16-Year Perspective for Hepatic Encephalopathy (HE) Treatment by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets for Years 2014, 2024 & 2030
  • Table 5: World Recent Past, Current & Future Analysis for Antibiotics by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 6: World Historic Review for Antibiotics by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 7: World 16-Year Perspective for Antibiotics by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 8: World Recent Past, Current & Future Analysis for Laxatives by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 9: World Historic Review for Laxatives by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 10: World 16-Year Perspective for Laxatives by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 11: World Recent Past, Current & Future Analysis for L-Ornithine L-Aspartate by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 12: World Historic Review for L-Ornithine L-Aspartate by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 13: World 16-Year Perspective for L-Ornithine L-Aspartate by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 14: World Recent Past, Current & Future Analysis for Other Drug Classes by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 15: World Historic Review for Other Drug Classes by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 16: World 16-Year Perspective for Other Drug Classes by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 17: World Recent Past, Current & Future Analysis for Hospital Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 18: World Historic Review for Hospital Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 19: World 16-Year Perspective for Hospital Pharmacies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 20: World Recent Past, Current & Future Analysis for Retail Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 21: World Historic Review for Retail Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 22: World 16-Year Perspective for Retail Pharmacies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 23: World Recent Past, Current & Future Analysis for Online Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 24: World Historic Review for Online Pharmacies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 25: World 16-Year Perspective for Online Pharmacies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
III. MARKET ANALYSIS
UNITED STATES
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United States for 2024 (E)
CANADA
JAPAN
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Japan for 2024 (E)
CHINA
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in China for 2024 (E)
EUROPE
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Europe for 2024 (E)
FRANCE
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in France for 2024 (E)
GERMANY
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Germany for 2024 (E)
ITALY
UNITED KINGDOM
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United Kingdom for 2024 (E)
SPAINRUSSIAREST OF EUROPE
ASIA-PACIFIC
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Asia-Pacific for 2024 (E)
AUSTRALIA
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Australia for 2024 (E)
INDIA
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in India for 2024 (E)
SOUTH KOREAREST OF ASIA-PACIFIC
LATIN AMERICA
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Latin America for 2024 (E)
ARGENTINABRAZILMEXICOREST OF LATIN AMERICA
MIDDLE EAST
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Middle East for 2024 (E)
IRANISRAELSAUDI ARABIAUNITED ARAB EMIRATESREST OF MIDDLE EAST
AFRICA
  • Hepatic Encephalopathy (HE) Treatment Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Africa for 2024 (E)
IV. COMPETITION

Companies Mentioned

  • AbbVie Inc.,
  • ASKA Pharmaceutical Co., Ltd.
  • Bausch Health Companies Inc.
  • Cosmo Pharmaceuticals NV
  • Eisai Co., Ltd.,
  • Hikma Pharmaceuticals PLC
  • Kannalife Sciences, Inc.
  • Lupin Limited
  • Mallinckrodt Pharmaceuticals
  • Merck & Co., Inc.
  • Norgine B.V.
  • Pfizer Inc.
  • Salix Pharmaceuticals, Inc.
  • Takeda Pharmaceutical Company Limited
  • Umecrine Cognition AB

Table Information