This book aims to fill research gaps in the search for chemotherapeutic and chemopreventive natural compounds. It includes a collection of detailed reviews focusing on bioactive compounds from plant sources that can be beneficial for cancer therapy. Topics covered include the role of antioxidants in cancer therapy, medicinal plants for cancer chemotherapeutics, bioactive compounds from marine plants, and a review of inhibiting nitric oxide reactions for preventing cancer.
Chapters are contributed by researchers who have provided detailed lists and descriptions of the relevant plant sources, the compounds and the biochemical reactions. The book includes references for advanced reading. This book is intended as a reference for scholars and healthcare professionals studying natural medicines for cancer prevention and treatment.
Readership
Scholars in the field of medicinal chemistry, pharmacology and herbal medicine.
Table of Contents
CONTENTS
PREFACE
LIST OF CONTRIBUTORS
CHAPTER 1 ROLE OF ANTIOXIDANTS IN CANCER THERAPY AND CHEMOPREVENTION
- P. Revathi, and K. Nirubama
INTRODUCTION
ANTIOXIDANTS AND TREATMENTS IN CANCER THERAPY
MECHANISM BEHIND ANTIOXIDANTS FOR CHEMOPREVENTION
MOLECULAR REACTION OF NATURAL COMPOUNDS FOR CHEMOPREVENTION
SKELETON MECHANISM FOR CHEMOPREVENTION
ANTIOXIDANTS IN CANCER THERAPY
CONCLUSION
REFERENCES
CHAPTER 2 MEDICINAL PLANTS AND CANCER CHEMOPREVENTION
- J. Jothika, J. Mohana Priya, G. Rajapandeeswari and M. Kalaimathi
INTRODUCTION
TYPES OF TREATMENT FOLLOWED FOR CANCER
ADVERSE EFFECTS OF CANCER TREATMENTS
ADVANTAGES OF HERBAL DRUGS OVER ALLOPATHIC DRUGS IN CHEMOPREVENTION
PLANTS WITH TREMENDOUS ANTICANCER ACTIVITIES
- Catharanthus Roseus
- Camptotheca Acuminata
- Annona Muricata L.
- Tinospora Cordifolia
- Withania Somnifera
Rumex Acetosella
CONCLUSION
ACKNOWLEDGEMENTS
REFERENCES
CHAPTER 3 BIOACTIVE COMPOUNDS DERIVED FROM MARINE SOURCES FOR
CANCER THERAPY AND CHEMOPREVENTION
- Ramasamy Indumathy, Thangavel Sathiya Kamatchi and Giriraj Kalaiarasi
INTRODUCTION
MECHANISM OF ANTICANCER ACTION
MARINE-BASED ANTICANCER DRUGS
MARINE-BASED ANTICANCER DRUGS IN CLINICAL AND PRECLINICAL TRIALS
CHEMOPREVENTION VIA NUTRACEUTICALS
CONCLUSION/SUMMARY AND FUTURE PROSPECTS
ACKNOWLEDGEMENTS
REFERENCES
CHAPTER 4 BIOACTIVE COMPOUNDS IN CANCER THERAPY AND CHEMOPREVENTION
Chenicheri Kizhakkeveettil Keerthana, Tennyson Prakash Rayginia, Sreekumar Usha Devi, Aiswarya, Sadiq Chembothumparambil Shifana and Ruby John Anto
INTRODUCTION
CONVENTIONAL STRATEGIES OF CANCER THERAPY: CURRENT STATUS AND LIMITATIONS
- Chemotherapy and Chemoresistance
CHEMOPREVENTION AND CHEMOSENSITIZATION APPROACHES IN CANCER THERAPY
PLANT-DERIVED BIOACTIVE COMPOUNDS AS NOVEL ANTI-CANCER AGENTS
- Curcumin
- Resveratrol
- Uttroside B
- Kaempferol
- Tryptanthrin
- Cucurbitacin B
- Gingerol
- Emodin
- Quercetin
- Genistein
- Lycopene
- Epigallocatechin Gallate
- Piperine
- Berberine
- Apigenin
- Luteolin
- Indirubin
- Silibinin
CONCLUSION AND FUTURE PERSPECTIVES
AUTHOR CONTRIBUTIONS
ACKNOWLEDGEMENTS
REFERENCES
CHAPTER 5 ANTIOXIDANT-OXIDATIVE STRESS BALANCE IN CHEMOPREVENTION OF CANCER
- Jameema Sidhic, Aparna Prasad, Arunaksharan Narayanankutty, Satheesh George and Blassan P. George
INTRODUCTION
- Cancer and Oxidative Stress
- Sources of Oxidative Stress in the Body
- Effects of Oxidative Damage at Cellular Level
- Antioxidants
- Cancer Therapy and Chemoprevention
- Role of Antioxidants in Cancer Therapy and Chemoprevention
CONCLUSION
REFERENCES
CHAPTER 6 INHIBITION OF NITRIC OXIDE AND FREE RADICAL PRODUCTION BY LEAF AND STEM EXTRACTS OF PSYCHOTRIA NILGIRIENSIS
Parimelazhagan Thangaraj, Pezzuto M. John, Tamara P. Kondratyuk, Eun-Jung Park, Murugan Rajan and Simeon O. Kotchoni
INTRODUCTION
MATERIALS AND METHODS
- Chemicals
- Collection and Identification of Plant Materials
- Preparation of Crude Extracts using Solvents from Plant Materials
- Antioxidant Assays
- DPPH Radical Scavenging Activity
- Total Antioxidant Capacity
- Determination of Oxygen Radical Antioxidant Capacity (ORAC)
- Assay for Measurement of Nitric Oxide (Nitrite Assay)
- Cell Culture
- Measurement of Nitric Oxide (Nitrite Assay)
- Cell Viability Assay
- LC-MS Data Acquisition and Analysis
- Statistical Analysis
RESULTS AND DISCUSSION
- Extractability of Polyphenolics
- Antioxidant Activity
- Free Radical Scavenging Activity Against DPPH·
- Total Antioxidant Capacity
- Oxygen Radical Scavenging Capacity
- Cell Viability Activity
- Sample Metabolite Profiling
- Identification of Compounds from Plant Extracts
CONCLUSION
ACKNOWLEDGEMENTS
REFERENCES
CHAPTER 7 PLANT-DERIVED COMPOUNDS FOR CHEMOPREVENTION AND CHEMOTHERAPY: FROM MOLECULAR MECHANISMS TO CLINICAL TRIALS
- Niharika Sharma, Vandana Varma and Sandhya Verma
INTRODUCTION
SIGNIFICANCE OF NATURAL COMPOUNDS FOR CANCER THERAPY AND CHEMOPREVENTION
CHEMICAL COMPOSITION
MECHANISM OF ACTION OF NATURAL PRODUCTS FOR MOLECULAR TARGETS
CLINICAL STUDIES OF IMPORTANT ANTICANCER PLANT BASED NATURAL PRODUCTS
IN VITRO STUDIES OF BENEFICIAL PLANT-DERIVED ANTICANCER COMPOUNDS
CHALLENGES IN THE DISCOVERY OF CHEMOPREVENTIVE DRUGS OBTAINED FROM PLANT-DERIVED COMPOUNDS
CONCLUSION AND FUTURE PERSPECTIVES
LIST OF ABBREVIATIONS
ACKNOWLEDGEMENTS
REFERENCES
CHAPTER 8 MEDICINAL PLANTS AND CANCER THERAPY AND CHEMOPREVENTION
- Giriraj Kalaiarasi, Thangavel Sathiya Kamatchi and S. Parveen
INTRODUCTION
- Medicinal Plants
- Cancer Therapy
- Chemoprevention
- Selected Medicinal Plants for Cancer Prevention and Therapy
CONCLUSION
ACKNOWLEDGEMENTS
REFERENCES
SUBJECT INDEX
Author
- Blassan George
