Gain an in-depth understanding of the concepts and processes of disease! Understanding Pathophysiology, 8th Edition provides a concise, comprehensive introduction to the way diseases work and how changes occur in the body as a result. With a clinically focused approach, the book begins by explaining cell structure and function. It then examines alterations by body systems and provides a practical guide to clinical manifestations, summaries of treatment, and health promotion strategies. This edition adds new algorithms, case studies for the Next-Generation NCLEX� Exam, and updated content on COVID-19, obesity, and cancer epidemiology. Written by a team of nursing educators led by Sue Huether, this text helps you develop clinical judgment and apply concepts to practice.
- NEW! Case studies for the Next-Generation NCLEX� Exam (NGN) are provided on the Evolve website, helping you develop clinical judgment.
- NEW! Content updates address infectious disease, COVID-19 and post-COVID conditions, systemic pathophysiologic effects of obesity, cancer epidemiology, and more.
- NEW! Additional new algorithms show the pathophysiologic pathways and progression of disease.
- Consistent presentation of each disease includes pathophysiology, clinical manifestations, and evaluation and treatment.
- Lifespan content includes nine separate chapters with pediatric content and special sections on aging within the adult chapters, along with special boxes that highlight aging and pediatric content.
- More than 1000 illustrations include photographs showing pathologic features of disease as well as micrographs showing normal and abnormal cellular structure.
- Risk Factor boxes show how certain risk factors are associated with specific diseases.
- Quick Check boxes appear at the end of major sections and are designed to help you recall the most important content.
- End-of-chapter Summary Reviews highlight the major concepts presented in each chapter.
- Did You Know boxes discuss new developments in biologic research, diagnostic studies, preventive care, treatments, and more.
- Key Terms are bolded, and listed with page numbers at the end of each chapter.
- Student resources on Evolve include animations, review questions, chapter summaries, and answers to the Quick Check questions.
Table of Contents
PART ONE: BASIC CONCEPTS OF PATHOPHYSIOLOGYUNIT 1: The Cell
1. Cellular Biology
2. Genes and Genetic Diseases
3. Epigenetics and Disease
4. Altered Cellular and Tissue Biology
5. Fluids and Electrolytes, Acids and Bases
UNIT 2: Mechanisms of Self-Defense
6. Innate Immunity: Inflammation and Wound Healing
7. Adaptive Immunity
8. Alterations in Immunity
9. Infection
10. Stress and Disease
UNIT 3: Cellular Proliferation: Cancer
11. Cancer Biology
12. Cancer Epidemiology
13. Cancer in Children and Adolescents
PART TWO: BODY SYSTEMS AND DISEASES
UNIT 4: The Neurologic System
14. Structure and Function of the Neurologic System
15. Pain, Temperature, Sleep, and Sensory Function
16. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
17. Alterations of the Brain, Spinal Cord and Peripheral Nerves
18. Alterations of Neurologic Function in Children
UNIT 5: The Endocrine System
19. Mechanisms of Hormonal Regulation
20. Alterations of Hormonal Regulation
21. Obesity, Starvation, and Anorexia of Aging
UNIT 6: The Hematologic System
22. Structure and Function of the Hematologic System
23. Alterations of Hematologic Function
24. Alterations of Hematologic Function in Children
UNIT 7: The Cardiovascular and Lymphatic Systems
25. Structure and Function of the Cardiovascular and Lymphatic Systems
26. Alterations of Cardiovascular Function
27. Alterations of Cardiovascular Function in Children
UNIT 8: The Pulmonary System
28. Structure and Function of the Pulmonary System
29. Alterations of Pulmonary Function
30. Alterations of Pulmonary Function in Children
UNIT 9: The Renal and Urologic Systems
31. Structure and Function of the Renal and Urologic Systems
32. Alterations of Renal and Urinary Tract Function
33. Alterations of Renal and Urinary Tract Function in Children
UNIT 10: The Reproductive Systems
34. Structure and Function of the Reproductive Systems
35. Alterations of the Female Reproductive System
36. Alterations of the Male Reproductive System
UNIT 11: The Digestive System
37. Structure and Function of the Digestive System
38. Alterations of Digestive Function
39. Alterations of Digestive Function in Children
UNIT 12: The Musculoskeletal and Integumentary Systems
40. Structure and Function of the Musculoskeletal System
41. Alterations of Musculoskeletal Function
42. Alterations of Musculoskeletal Function in Children
43. Structure, Function, and Disorders of the Integument
44. Alterations of the Integument in Children
Index
Authors
Sue E. Huether Professor Emeritus, College of Nursing, University of Utah, Salt Lake City, UT. Kathryn L. McCance Professor, College of Nursing, University of Utah, Salt Lake City, UT. Valentina L. Brashers Professor of Nursing and Woodard Clinical Scholar,Attending Physician in Internal Medicine,Director, Center for ASPIREUniversity of Virginia.
