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GABA in Plants. Biosynthesis, Plant Development, and Food Security. Edition No. 1

  • Book

  • 368 Pages
  • February 2025
  • John Wiley and Sons Ltd
  • ID: 6013984
A comprehensive overview of the role played by GABA as a signaling molecule in plants

In GABA in Plants: Biosynthesis, Plant Development, and Food Security, the editors deliver an expertly balanced discussion of the role played by GABA as a signaling molecule in plants, plant development, stress acclimation, as well as its potential impact on crop productivity under changing environmental conditions.

From explorations of the discovery of GABA in plants to presentations of GABA biosynthesis pathways, GABA crosstalk with other metabolites, and GABA’s role in programmed cell death in plants, this book is an essential treatment of a four-carbon signaling molecule that may yet prove pivotal in sustaining crop production in the face of climate change.

Readers will also find: - A thorough introduction to GABA and its involvement in nodulation in and wounding stress in plants - Comprehensive explorations of plant stress responses and tolerance mechanisms - Practical discussions of GABA priming induced modulations in the redox homeostasis of plants under osmotic stress - Complete treatments of GABA and heat, oxidative, cold, bacterial, mediated salt, and chilling stressors

Perfect for students and scientists working in plant biology and physiology, crop protection, food security, nutrition, and biotechnology, GABA in Plants will also benefit professionals working in the agricultural, food, and pharmaceutical industries.

Table of Contents

Contributors xiii

Preface xix

1 Discovery and Background of GABA in Plants 1
Gubbi Vani Ishika, Deepthi Puttegowda, Ranjith Raj, Manjunath Dammalli, and Ramith Ramu

Abbreviations 1

Introduction 1

History 2

Background 3

The GABA Metabolic Pathway in Plants 4

Structure and Conformation of GABA 6

Roles and Functions of GABA 7

Plant Development 8

Carbon and Nitrogen Metabolic Balance 8

Enhancement of Storage Quality and Shelf Life 9

pH Regulation 9

Compatible Osmolyte 10

Biotic and Abiotic Stress 10

Temperature Stress 11

Low Temperature 11

High Temperature 11

Drought 12

Heavy Metals 12

Ros 12

Salt 13

Conclusion 14

What People Will Learn by Reading This Chapter 14

How This Chapter Helps People Due to its Collective Content 15

References 15

2 GABA Biosynthesis Pathways and its Signaling in Plants 19
Nader Adamipour, Farzad Nazari, and Jaime A. Teixeira da Silva

GABA Production and Degradation Pathway 19

Is GABA Only a Metabolite? 21

Role of GABA in Signaling between Eukaryotes and Bacteria 22

The Role of GABA Signaling in Regulating Pollen Tube Growth 23

The Role of GABA Signaling in Regulating Stomatal Aperture 23

Role of the GABA Shunt in Plants 24

The Effect of GABA on Plant Growth 24

The Effect of GABA on the Regulation of C:N Metabolism 25

The Role of GABA in Improving Shelf Life and the Storage Quality of Products 26

Role of GABA in Cytosolic pH Homeostasis 28

The Impact of GABA on ROS 28

Crosstalk of GABA with Other Signaling Molecules 29

Abscisic Acid 29

Ethylene 29

Auxins 30

Cytokinins 30

Gibberellins 31

Interaction of GABA, PAs, NO, and H 2 O 2 31

GABA and Proline Interaction 32

Conclusion and Future Prospects 32

References 33

3 GABA and Its Crosstalk with Other Metabolites in Relation to Abiotic Stress Responses in Plants 43
Akhilesh Kumar Pandey and Nishtha Srivastava

Introduction 43

Enzymes in GABA Metabolic Pathways 44

Role of GABA Under Stressful Conditions in Plants 45

GABA and Salt Stress 46

GABA and Drought Stress 46

GABA and Chilling Stress 48

Crosstalk of GABA with Other Metabolites and Chemicals 48

GABA with H 2 O 2 49

GABA with Nitric Oxide (NO) 50

GABA with Calcium 50

Interplay of GABA with Plant Hormones 51

GABA with Auxin 51

GABA with Abscisic Acid 51

GABA with Ethylene 52

Mechanisms of Action of GABA in Plants Under Stress 52

Conclusions and Future Perspectives 54

References 54

4 GABA as a Signaling Molecule in Plants 65
Navya Sreepathi, Deepthi Puttegowda, Nagma Firdose, Bhavya Somaplara Gangadharappa, V B Chandana Kumari, and Ramith Ramu

Abbreviations 65

Introduction 66

GABA in Plants as a Stress Response 67

GABA as a Drought-Induced Stress Response in Plants 68

GABA as a Stress Response in Plants Induced by Salinity 70

GABA as a Temperature-Induced Stress Response in Plants 73

GABA’s Role in Mediating Oxidative Stress-Induced Responses in Plants 74

GABA’s Role in Mediating Pathogen and Herbivore Attack Stress-Induced Responses in Plants 76

GABA Signaling in attKLM Operon (Bacteria) 76

GABA Signaling Against Viruses, Fungi, and Insect Attack 77

GABA Signaling in Plant Growth and Development 78

GABA Signaling in Seed Germination 79

GABA in ABA (Abscisic Acid) Signaling Pathway 80

GABA Signaling for Auxin Biosynthesis for Plant Growth Under Fe Deficiency 81

GABA in Root and Shoot Development 81

GABA Influence in Pollen Tube Elongation 83

GABA in Flowering, Fruit Development, and Ripening 83

GABA-Mediated Regulation of Stomatal Aperture in Plants 85

GABA Regulation in Stomatal Closure 85

GABA Signaling for GORK Channels Under Hypoxia 86

GABA in Ion-Exchange Regulation 86

GABA’s Interplay with Diverse Signaling Pathways in Plants 88

Conclusion and Future Prospectives 89

References 90

5 GABA and Drought Stress 97
Petronia Carillo and Andrea Carra

Introduction 97

GABA Shunt in Plants 99

GABA Accumulates in Plants Under Drought Stress 99

GABA Accumulation Increases Drought Tolerance 100

GABA Signaling and the Regulation of Stomatal Opening 102

Conclusion 105

References 105

6 The Role of GABA on Programmed Cell Death and Senescence in Plants 111
Fazilet Özlem Albayrak, Filiz Vardar, and Nihal Gören-Sağlam

Introduction 111

GABA Pathways 112

The Roles of GABA under Stress Conditions 113

GABA as a Signal Molecule 115

GABA-Mediated Avoidance from PCD 116

The Role of GABA on Leaf Senescence 118

Conclusions 121

References 121

7 GABA and Nodulation in Plants 129
Shubhra Khare, Ajey Singh, Km Niharika, Nimisha Amist, Zeba Azim, Rangoli Krishna, Nishtha Srivastava, and Narsingh Bahadur Singh

Introduction 129

Nodulation in Leguminous Plants 130

Functioning of γ-Aminobutyric Acid in Plants 132

Functioning of GABA in Nodulation 134

Conclusions and Future Prospects 136

References 137

8 GABA and Wounding Stress in Plants 143
Neeraj Kumar Dubey, Vijay Bahadur Yadav, Kunwar Deelip Singh, Satyendra Kumar Yadav, Ran Vijay Singh, Amarjeet Singh, and Jogeswar Panigrahi

Introduction 143

GABA: An Important Molecule for Plant 144

GABA and Abiotic Stress 145

Biotic Stress and Wound-Mediated GABA Fluctuation 146

Transgenic Plants Expressing GABA and Effect on Herbivorous Performance 147

References 148

9 GABA in Plant Stress Response and Tolerance Mechanisms 155
Şerife Palabıyık, İrem Çetinkaya, Tülay Öztürk, and Melike Bor

Introduction 155

Abiotic Stress and GABA 158

Salt Stress and GABA 159

Drought and GABA 161

High Temperature and GABA 162

Cold Stress and GABA 163

Heavy Metal Stress and GABA 164

Biotic Stress and GABA 165

Conclusion and Future Prospects 166

References 166

10 GABA Priming Induced Modulations in the Redox Homeostasis of Plants under Osmotic Stress 173
Kakkuzhiyulla Parambath Raj Aswathi, Kolothodi Chandran Jisha, Mathew Veena, Akhila Sen, Nair Gopalakrishnan Sarath, and Jos Thomas Puthur

Introduction 173

Role of GABA in Plants 174

GABA Priming and Oxidative Stress Mitigation 174

Morphological Response 176

Physiological Response: With Special Emphasis on ROS and Antioxidant Machinery 176

Molecular Response 180

Stress Signaling Cross-Talk 181

Conclusion and Future Prospects 182

Acknowledgments 182

References 182

11 Gamma-Aminobutyric acid-Mediated Heavy Metal Stress Tolerance in Plants 189
Srijita Ghosh and Aryadeep Roychoudhury

Introduction 189

Health Benefits of GABA 191

Biosynthesis of GABA 191

GABA Transport in Plants 192

Role of GABA in Abiotic Stress Tolerance 194

GABA and Drought Stress 194

GABA and Polyamines in Drought Stress 197

GABA and Salt Stress 198

GABA and Heat Stress 199

GABA and Cold Stress 200

GABA and Heavy Metal Stress 200

Conclusion 202

Acknowledgments 202

References 203

12 GABA and Heat Stress 211
Zeba Azim, Shubhra Khare, Narsingh Bahadur Singh, Km Niharika, Ajey Singh, Ravi Kumar Yadav, and Nimisha Amist

Introduction 211

GABA-Biosynthesis and Transport/Pathways in Plant 213

GABA Morphological and Physiological Functions within Plants 213

GABA and Abiotic Stress 214

GABA and Heat Stress 215

Conclusion 217

References 218

13 GABA and Oxidative Stress and the Regulation of Antioxidants 225
Somayeh Rastegar and Pegah Sayyad-Amin

Introduction 225

Types and Characteristics of ROS 226

ROS Generation in Plants under Normal and Stress Conditions 227

The Importance of ROS Compartmentation for Plant Stress Adaptation 228

Antioxidant Defense System in Plants 229

Nonenzymatic Antioxidants 229

Enzymatic Antioxidants 231

Relationships of GABA Shunt and ROS during Stress Conditions 233

The Response of GABA under Abiotic Stress Conditions 235

Synthesis of Ascorbic Acid (AsA) 235

Synthesis of Phenolic Compounds 236

Conclusion 237

References 238

14 GABA in Relation to Cold and Chilling Stress 243
Somayeh Rastegar and Emad Hamdy Khedr

Introduction 243

Plant Strategies to Overcome Cold Stress 245

γ-Aminobutyric Acid (GABA) 247

GABA Biosynthesis in Plants 247

Response Strategies of GABA in Cold Stress Tolerance 248

Mitigating ROS Generation and Improving Antioxidant Systems During Cold Stress in Plants 248

GABA Improves Nonenzyme Antioxidant System 250

Regulating Phenol Metabolism 250

Regulating Ascorbic Acid Metabolism 251

Promoting Polyamine Synthesis 252

Protecting Chloroplast Integrity 253

Maintaining Higher ATP Content and Energy Charge 254

Future Perspectives, Challenges, and Conclusion 256

Future Perspectives 256

Challenges 256

Conclusion 256

References 257

15 Role of GABA Under Bacterial Stress in Plants 263
Kuldeep Lahry, Akhilesh Kumar Pandey, and Sudhir Singh

Introduction 263

GABA and Biotic Stress in Plants 266

GABA and Bacterial Stress Response in Plants 267

Molecular Basis of GABA Accumulation in Response to Bacterial Pathogens 269

Glu-dependent Accumulation of GABA 269

Glu-independent Accumulation of GABA 270

The Involvement of GABA in the Interaction of Microbes with Plants 270
Ralstonia solanacearum 270

Pseudomonas syringae pv. tabaci 271

Conclusions and Future Perspectives 272

References 273

16 GABA-Mediated Salt Stress Tolerance Through Physiological and Molecular Mechanisms 287
Riya Johnson, Joy Mulakkal Joel, Koravantakamparambil Sulaiman Anjitha, Louis Noble, Parammal Faseela, and Jos Thomas Puthur

Introduction 287

Concept of Salt Stress to Plants 288

Salt Stress and Related Metabolic Changes 289

GABA and Salinity Stress Tolerance 290

GABA Improves Photosynthesis and Chlorophyll Fluorescence Parameters Under Salt Stress 291

GABA Alleviates Oxidative Injury Induced by Salt Stress via Accumulation of the Osmolytes in Plants 295

Molecular Changes Associated with GABA-Induced Salinity Stress Tolerance 298

Conclusion 299

Acknowledgments 299

References 299

17 GABA and Nutrient Deficiency 305
Km Niharika, Shubhra Khare, Ajey Singh, Zeba Azim, Nimisha Amist, and Narsingh Bahadur Singh

Introduction 305

An Overview of GABA 306

Role of GABA in Plant Development 306

Role of GABA in Different Stress Tolerance 307

Different Mineral Nutrients and Their Role in Plant Development 308

Different Nutrient Deficiencies in Plants 310

Role of GABA in Nutrient Deficiency 311

Concluding Remarks 315

References 315

18 GABA and Plant-Derived Therapeutics 321
Lakshmi Jayaram, Deepthi Puttegowda, V. H. Pushpa, Shashank M. Patil, and Ramith Ramu

List of Abbreviations 321

Introduction 322

The Mechanism of GABA in Action: Neurotransmission and Its Effect on Neurons 322

Plants with Reported GABAergic Activity: A Novel Source of Therapeutics 325

Passiflora incarnata (Passion Flower) 327

Piper methysticum (Kava) 328

Withania somnifera (Ashwagandha, Indian Ginseng, Winter Cherry) 328

Valeriana officinalis, (Valeriana) 329

Scutellaria lateriflora, (Scullcap, Blue Skullcap) 330

Melissa officinalis, (Lemon Balm) 330

Ginkgo biloba, (Maiden Hair) 330

Humulus lupulus, (Hops) 331

Matricaria recutita, (True Chamomile) 331

Centella asiatica, (Gotu Kola) 332

Conclusion and Future Perspective 332

References 333

Index 343

Authors

Samiksha Singh Banaras Hindu University, Varanasi, India. Durgesh Kumar Tripathi Motilal Nehru National Institute of Tech. Vijay Pratap Singh University of Allahabad, Prayagraj, India.