Animal Models of Disease, Part C, Volume 192 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Using C. Elegans as a model for Neurodegenerative disease: Methodology and Evaluation, Modelo Animal de Esclerosis Multiple: Encefalomielitis Autoimmune Experimental (EAE, New mouse model to study aneurysm development, Spinal Nerve Ligation: An Experimental Neuropathic Pain Model in Rats and Mice, Identifying therapeutic compounds for Autosomal Dominant Optic Atrophy (ADOA) through screening in the nematode C. elegans, Eµ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia, and much more.
Other chapters cover Purification and characterization of kidney-infiltrating leukocytes in a mouse model of lupus nephritis, Differences in intratumor innate lymphoid cell composition between orthotopic and spontaneous pancreatic mouse models, Assessing motor development and function in mouse models of neurodevelopmental disorders, Analysis of Gut Microbiota profile targeted to multi hypervariable regions of 16S rRNA in hypertensive heart failure rat model, and more.
Other chapters cover Purification and characterization of kidney-infiltrating leukocytes in a mouse model of lupus nephritis, Differences in intratumor innate lymphoid cell composition between orthotopic and spontaneous pancreatic mouse models, Assessing motor development and function in mouse models of neurodevelopmental disorders, Analysis of Gut Microbiota profile targeted to multi hypervariable regions of 16S rRNA in hypertensive heart failure rat model, and more.
Table of Contents
PrefaceLorenzo Galluzzi, Fernando Aranda, Aitziber Buque and Jos� Manuel Bravo-San Pedro
1. Characterizing tumour-infiltrating group 1 innate lymphoid cells in PyMT breast tumours
Nicolas Jacquelot, Sara Lamorte, Alisha Elford, Douglas Chung, Kiichi Murakami and Tracy McGaha
2. The current models unravel the molecular mechanisms underlying the intricate pathophysiology of Alzheimer’s disease using Zebrafish.
Ginpreet Kaur and Baban Thawkar
3. Colitis mouse model
Daniel Ajona, Yaiza Senent, Ana Rem�rez and Beatriz Tavira
4. Matching model with mechanism: appropriate animal models for studying various aspects of diabetes pathophysiology
Aileen King and Lydia Faith Daniels Gatward
5. Induction of sepsis in a rat model by the cecal ligation and puncture technique. Application for the study of experimental acute renal failure
Alberto Lazaro Fernandez Sr. and Mar�a �ngeles Gonz�lez-Nicol�s
6. Human cancer cells xenografts to assess the efficacy of granulysin-based therapeutics
Alberto Anel Bernal
7. Antimicrobial regime for gut microbiota depletion in experimental mice models
Francisco Lozano, Laura Carrillo-Serradell, Alessandra Borgognone, Marc Noguera-Julian, Violeta Planells-Romeo, Luc�a Arag�n-Serrano, Mariona Parera, Sergi Casad�-Llombart, Mar�a Velasco-de Andr�s and Roger Paredes
8. Evaluating polyglutamine protein aggregation and toxicity in transgenic Caenorhabditis elegans models of Huntington's disease
Leticia Priscilla Arantes and Felix Alexandre Antunes Soares
9. A model of intraperitoneal ovarian cancer to study tumor responses to radioimmunotherapy
Julie Constanzo, Jean-Pierre POUGET, Clara Diaz Garcia-Prada and Salima Atis
10. Metallic nanoparticles biodistribution for the study of lymphoma in animal models
Laura Mondrag�n Mart�nez, Barbara Chalhoub and V�ctor F. Puntes
11. Stereotactic injection of murine brain tumor cells for neuro-oncology studies
Mara De Martino, Claire I. Vanpouille-Box, Camille Daviaud and Mar�a Cecilia Lira
12. Evaluating amyloid-beta aggregation and toxicity in transgenic Caenorhabditis elegans models of Alzheimer's disease
Leticia Priscilla Arantes, Felix Alexandre Antunes Soares and Larissa Marafiga Cordeiro
