Cholecystokinin. From Gallbladder to Cognition and Beyond. Molecular Mediators in Health and Disease: How Cells Communicate

Table of Contents

Part I History 1. Milestones in the CCK history Jens F. Rehfeld, Christine Feinle-Bisset Part II Biology of CCK 2. Evolutionarily conserved roles of cholecystokinin signaling Dick N�ssel, Shunfan Wu 3. The biogenesis and cell-specific expression of cholecystokinin peptides Jens F. Rehfeld, Christine Feinle-Bisset 4. Cholecystokinin in intestinal and extraintestinal endocrine cells Marta Santoz Hernandez, Frank Reimann, Fiona M. Gribble 5. Cholecystokinin in the central and peripheral nervous system Tomas H�kfelt, Swapnali Barde, Wen Zhong, Jufang He 6. Cholecystokinin 1 and cholecystokinin 2 receptors Laurence J Miller 7. The relationship between cholecystokinin and gastrin Jens F. Rehfeld Part III Physiology of CCK 8. Intestinal cholecystokinin secretion Rashmi Chandra, Rodger A. Liddle 9. Cholecystokinin and the gut-brain axis Kirsteen Browning, Amanda Page

1. Cholecystokinin and the gallbladder

Adrian A. M. Masclee, Gwen M. C. Masclee 11. Cholecystokinin and the exocrine pancreas John A. Williams 12. Islet effects of cholecystokinin and exploitation in diabetes Neil Tanday, Nigel Irwin, Peter Flatt 13. Cholecystokinin and gastrointestinal motor function Javad Anjom Shoae, Michael Horowitz, Christine Feinle-Bisset 14. Effect of cholecystokinin on food intake and appetite Frank A. Duca 15. Cholecystokinin, nutrient preference and taste aversion Jo E. Lewis, Fiona M. Gribble, Frank Reimann 16. Cholecystokinin in peripheral and central cardiovascular control Tony J. M. Verberne, Bashair M. Mussa 17. Cholecystokinin expression in the heart and its clinical implications Jens P. Goetze, Jens F. Rehfeld Part IV Methods used for CCK research 18. Measurement of cholecystokinin in biological fluids Jens F. Rehfeld, Jens P. Goetze 19. Cholecystokinin knockout mice: peripheral and central phenotypes Chunmin C. Lo, Dennis D. Black, Patrick Tso Part V CCK in disease 20. Cholecystokinin in obesity and other disorders of eating Kimberly R. Smith, Tim H. Moran 21. Cholecystokinin in tumors Jens F. Rehfeld 22. Cholecystokinin and panic disorder Jacques Bradwejn, Diana Koszycki 23. Cholecystokinin and the immune system John J. Worthington 24. Cholecystokinin and its receptors in nociception and pain Nesia A. Zurek, Sascha R. A. Alles Part V CCK-based novel therapeutic approaches 25. Potential novel therapeutics targeting cholecystokinin 1 receptors Laurence J. Miller Part VI Conclusion 26. Reflections on cholecystokinin research past, present and future Jens F. Rehfeld, Christine Feinle-Bisset

Authors

Christine Feinle-Bisset Professorial Research Fellow, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Australia. Professor Christine Feinle-Bisset has a PhD in Nutrition and GI Physiology from the University of Stuttgart-Hohenheim, Germany. After gaining research experience at the University of Sheffield, UK and the University of Zurich, Switzerland, she joined the University of Adelaide in 2000, where she is currently a Professorial Research Fellow and a lead investigator in the Centre of Research Excellence in Translating Nutritional Science to Good Health. Her research is clinical and relates to the impact of nutrients on appetite, GI motor and hormone function and perception, in health, obesity and functional dyspepsia. Her work has contributed significantly to current concepts of the role of gastrointestinal mechanisms, including gut hormones and gastrointestinal motor activity, in the regulation of energy intake in health and obesity, and symptom generation in functional dyspepsia. She has published more than 220 publications, with over 15,000 citations. Jens F Rehfeld Professor, Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark. Professor Jens F. Rehfeld has an MD from the University of Aarhus, and later DMSc and DSc in Clinical Biochemistry from the University of Copenhagen. He became professor in Medical Biochemistry at University of Aarhus in 1975, and of Clinical Biochemistry, University of Copenhagen, in 1981. He was also administrative head of the Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, until 2010.
His main research theme is bioactive peptides (in particular gastrin, cholecystokinin, and insulin), their biosynthesis, methods for measurement, and clinical relevance. He has published approximately 1100 publications, including 650 original articles, 90 review articles, 55 textbook chapters, and 8 books, and has more than 43,000 citations.