Cholecystokinin. From Gallbladder to Cognition and Beyond. Molecular Mediators in Health and Disease: How Cells Communicate

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Book
April 2025
Elsevier Science and Technology
ID: 6016341

Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology, and pathophysiological roles of cholecystokinin (CCK) peptides. The book begins with a historical overview before providing in-depth chapters on the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function.

Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.

Part I History
1. Milestones in the history of cholecystokinin
Jens F. Rehfeld, Christine Feinle-Bisset

Part II Biology of cholecystokinin
2. Evolutionarily conserved roles of cholecystokinin signaling
Dick N�ssel, Shunfan Wu

3. The biogenesis and cell-specific expression of cholecystokinin peptides
Jens F. Rehfeld, Christine Feinle-Bisset

4. Cholecystokinin in intestinal and extraintestinal endocrine cells
Marta Santoz Hernandez, Frank Reimann, Fiona M. Gribble

5. Cholecystokinin in the central and peripheral nervous system
Tomas H�kfelt, Swapnali Barde, Wen Zhong, Jufang He

6. Cholecystokinin 1 and cholecystokinin 2 receptors
Laurence J Miller

7. The relationship between cholecystokinin and gastrin
Jens F. Rehfeld

Part III Physiology of cholecystokinin
8. Intestinal cholecystokinin secretion
Rashmi Chandra, Rodger A. Liddle

9. Cholecystokinin and the gut-brain axis
Kirsteen Browning, Amanda Page

Cholecystokinin and the gallbladder

Adrian A. M. Masclee, Gwen M. C. Masclee

11. Cholecystokinin and the exocrine pancreas
John A. Williams

12. Islet effects of cholecystokinin and exploitation in diabetes
Neil Tanday, Nigel Irwin, Peter Flatt

13. Cholecystokinin and gastrointestinal motor function
Javad Anjom Shoae, Michael Horowitz, Christine Feinle-Bisset

14. Effect of cholecystokinin on food intake and appetite
Frank A. Duca

15. Cholecystokinin, nutrient preference and taste aversion
Jo E. Lewis, Fiona M. Gribble, Frank Reimann

16. Cholecystokinin in peripheral and central cardiovascular control
Tony J. M. Verberne, Bashair M. Mussa

17. Cholecystokinin in cardiac myocytes
Jens P. Goetze, Jens F. Rehfeld

Part IV Methods used for cholecystokinin research
18. Measurement of cholecystokinin in biological fluids
Jens F. Rehfeld, Jens P. Goetze

19. Cholecystokinin knockout mice: peripheral and central phenotypes
Chunmin C. Lo, Dennis D. Black, Patrick Tso

Part V cholecystokinin in disease
20. Cholecystokinin in obesity and other disorders of eating
Kimberly R. Smith, Tim H. Moran

21. Cholecystokinin in tumors
Jens F. Rehfeld

22. Cholecystokinin and panic disorder
Jacques Bradwejn, Diana Koszycki

23. Cholecystokinin and the immune system
John J. Worthington

24. Cholecystokinin in nociception and pain
Nesia A. Zurek, Sascha R. A. Alles

Part VI cholecystokinin -based novel therapeutic approaches
25. Potential therapeutics targeting cholecystokinin 1 receptors
Laurence J. Miller

Part VII Conclusion
26. Reflections on cholecystokinin research: past, present and future
Jens F. Rehfeld, Christine Feinle-Bisset

Authors

Christine Feinle-Bisset Professorial Research Fellow, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Australia. Professor Christine Feinle-Bisset has a PhD in Nutrition and GI Physiology from the University of Stuttgart-Hohenheim, Germany. After gaining research experience at the University of Sheffield, UK and the University of Zurich, Switzerland, she joined the University of Adelaide in 2000, where she is currently a Professorial Research Fellow and a lead investigator in the Centre of Research Excellence in Translating Nutritional Science to Good Health. Her research is clinical and relates to the impact of nutrients on appetite, GI motor and hormone function and perception, in health, obesity and functional dyspepsia. Her work has contributed significantly to current concepts of the role of gastrointestinal mechanisms, including gut hormones and gastrointestinal motor activity, in the regulation of energy intake in health and obesity, and symptom generation in functional dyspepsia. She has published more than 220 publications, with over 15,000 citations. Jens F Rehfeld Professor, Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark. Professor Jens F. Rehfeld has an MD from the University of Aarhus, and later DMSc and DSc in Clinical Biochemistry from the University of Copenhagen. He became professor in Medical Biochemistry at University of Aarhus in 1975, and of Clinical Biochemistry, University of Copenhagen, in 1981. He was also administrative head of the Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, until 2010.
His main research theme is bioactive peptides (in particular gastrin, cholecystokinin, and insulin), their biosynthesis, methods for measurement, and clinical relevance. He has published approximately 1100 publications, including 650 original articles, 90 review articles, 55 textbook chapters, and 8 books, and has more than 43,000 citations.

Table of Contents

Authors

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