Narcolepsy. Integrating Basic and Clinical Knowledge

Table of Contents

Part I: PATHOPHYSIOLOGY AND NEUROBIOLOGY
1. Understanding Sleep in Narcolepsy: Sleep Physiology and Neurobiology
2. Pathophysiology of Narcolepsy: Genetics and Immune System
3. The Hypocretin/Orexin, Histamine, and Other Neurotransmitters in Narcolepsy: An Animal Model Perspective
4. The Gut-Brain Axis in Narcolepsy: Emerging Research on Microbiota, Diet, and Sleep

Part II: CLINICAL ASPECTS
5. Types of Narcolepsy and Their Symptoms: Differential Diagnosis and Misdiagnosis
6. Delayed Diagnosis of Narcolepsy: Causes and Implications
7. Diagnostic Tools for Narcolepsy: Sleep Studies, MSLT, and More
8. Narcolepsy in Children and Adolescents: Diagnosis, Management, and Challenges
9. Narcolepsy and Pregnancy: Risks and Strategies for Management
10. Aging with Narcolepsy: Understanding the Unique Challenges for Older Adults
11. Medical Co-morbidities of Narcolepsy
12. More Than Just Narcolepsy: The Importance of Recognizing Concurrent Sleep Disorders
13. Narcolepsy and Circadian Rhythm Disorders: Diagnosis and Management
14. The Hidden Link Between Narcolepsy and Autonomic Dysfunction: A Closer Look
15. Narcolepsy and Metabolic Rate: What Do We Know?
16. Narcolepsy and Driving: Safety Issues and Regulations
17. The Natural History of Narcolepsy: Lessons from Longitudinal Studies
18. Narcolepsy and COVID-19: Implications for Diagnosis, Treatment, and Management
19. Neuroimaging in Narcolepsy: Advances in Understanding Pathophysiology and Diagnosis
20. The Distinctive Characteristics of REM Sleep and Dreams in Narcolepsy

Part III: BEHAVIORAL AND PSYCHOSOCIAL CONSIDERATIONS
21. The Hidden Burden of Narcolepsy: Anxiety and Depression Among Patients
22. Understanding Psychosis and Behavioral Abnormalities in Narcolepsy Patients
23. Narcolepsy and Cognitive Impairment: Causes and Management
24. Coping with Narcolepsy: Lifestyle Changes, Academic Performance Challenges, and Employment Strategies for Success
25. Narcolepsy and Relationships: Navigating Intimacy, Family, and Social Life
26. Narcolepsy and Advocacy: Awareness, Education, and Community Building
27. Voices of Narcolepsy: Patient Perspectives on Living with a Chronic Condition
28. The Complexities of Medico-legal Assessment of Disability in Narcolepsy

Part IV: SPECIFIC MANAGEMENT
29. Current Pharmacological Treatments for Narcolepsy
30. Exploring the Potential of Cognitive Behavioral Therapy as an Adjunct to Medication in Narcolepsy Management
31. Emerging Therapies for Narcolepsy: Immunotherapy, Gene Therapy, and Beyond
32. Exploring the Role of Biomarkers and Epigenetics in Narcolepsy: Implications for Diagnosis and Treatment
33. The Future of Narcolepsy Treatment: What Role Will Artificial Intelligence Play?
34. Narcolepsy and Chronic Pain: Implications and Management
35. Navigating the Economic Costs of Narcolepsy in Managed Care.

Authors

Seithikurippu R. Pandi-Perumal President and Chief Executive Officer, Somnogen Canada Inc, Canada. S.R. Pandi-Perumal, MSc is the President and Chief Executive Officer of Somnogen Canada Inc., a Canadian corporation. Pandi is popular among the sleep community. He is a world-acclaimed sleep researcher and has authored over 300 publications and has edited over 25 high-profile academic volumes dealing with various sleep-related topics. His name is also on the list of the top 2% of scientists in the world, compiled by Stanford University, Elsevier, and SciTech Strategies. Drawn to the benefits and significance of the sleep cycle, his personal and professional careers have been involved in advocating/achieving a good night's slumber. Further details about the editor can be viewed at https://pandi-perumal.blogspot.com. Ahmed S. BaHammam King Saud University, Saudi Arabia.

AS BaHammam is a tenured Professor of Pulmonary and Sleep Medicine at King Saud University (KSU), Riyadh, Saudi Arabia. King Saud University awarded him the Lifetime Achievement Award (2016) for his contribution to sleep medicine research. He published 300 scientific articles, 50 chapters, and two books about sleep medicine and technology. He is the Editor-in-Chief of Nature & Science of Sleep (A Q1 journal), The Associate Editor of Ann Thoracic Med, Frontiers in Neurology, and Frontier in Psychiatry.

Professor BaHammam's research focuses on several sleep-related topics, including obesity hypoventilation syndrome, central hypersomnolence disorders, and the impact of intermittent fasting and mealtime on sleep and circadian rhythm, sleep monitoring, and recently, sleep and circadian rhythm changes during the COVID-19 pandemic.

AS BaHammam is the Executive Director of Academic Affairs at the Medical City, King Saud University; the Director of Prince Naif Health Research Center; and the Director, University Sleep Research Center at King Saud University. As a prolific writer and editor, his name is also on the list of the top 2% of scientists in the world, compiled by Stanford University, Elsevier, and SciTech Strategies. Further information about the editor can be found at https://faculty.ksu.edu.sa/en/ashammam Amir Sharafkhaneh Baylor College of Medicine, USA.

Dr. Amir Sharafkhaneh is an associate professor of medicine and program director of Sleep Medicine at Baylor College of Medicine (where he did his Fellowship) and is a medical director at the Sleep Disorders and Research Center at the DeBakey VA Medical Center. Dr. Sharafkhaneh is board certified sleep medicine. Since 2002, He has conducted research studies on respiratory diseases including asthma, COPD, bronchitis and emphysema. He is an active member of the American Academy of Sleep Medicine, the American Thoracic Society and European Respiratory Society, and a fellow of the American College of Chest Physicians. Dr Sharafkhaneh is on the review panel of the journals Chest Respiratory Medicine, International Journal of COPD, Thorax, Journal of Affective Disorders and Sleep. He received his MD at the Tehran University of Medical Sciences in 1990 and his PhD in public health at the Baylor College of Medicine in 2008.