Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules offers a comprehensive exploration of the pharmacological potential of plant-derived compounds. The book provides an in-depth look at the therapeutic applications of phytomolecules in various health conditions.
It begins with an analysis of bioactive phloroglucinol compounds and progresses to cover plant-based approaches for managing rheumatoid arthritis, diabetes, cancer, neurological disorders, and antiviral activity. The volume also covers the molecular mechanisms of flavonoids, the preclinical pharmacology of Indian medicinal herbs, and the neuroprotective role of andrographolide in Parkinson’s disease. Designed to inform and inspire, this book is ideal for researchers, clinicians, and students interested in the therapeutic potential of natural products.
Readership
Undergraduate and graduate students and researchers interested in the therapeutic potential of natural products.
Table of Contents
PREFACE
LIST OF CONTRIBUTORS
CHAPTER 1 PHARMACOLOGICAL POTENTIAL OF BIOACTIVE PHLOROGLUCINOL
COMPOUNDS OF THE PLANT KINGDOM
- Yvan Anderson Tchangoue Ngandjui, Niranjan Das, Subhash C. Mandal and Simeon Fogue Kouam
INTRODUCTION
OVERVIEW OF PHLOROGLUCINOL COMPOUNDS
- Definition
- Phloroglucinol as a Scaffold in Biology
- Phloroglucinol Derivatives
- Monomeric Phloroglucinols
PLANT KINGDOM OF PHLOROGLUCINOLS COMPOUNDS AND THEIR USES
- Asteraceae
- Euphorbiaceae
- Hypericaceae
- Lamiaceae
- Myrtaceae
- Rosaceae
PHARMACOLOGICAL ACTIVITIES OF PHLOROGLUCINOL COMPOUNDS
- Antibacterial Activity
- Antifungal Activity
- Anti-inflammatory Activity
- Antileishmanial Activity
- Antiplasmodial Activity
- Antiproliferative Activity
- Cytotoxicity Activity
- Ferroptosis Inhibitory Activity
- α-glucosidase Inhibitory Activity
CONCLUSION
REFERENCES
CHAPTER 2 RAGING THE WAR AGAINST RHEUMATOID ARTHRITIS WITH PLANT-DERIVED PRODUCTS: SKEPTICISM TO CLINICAL DEVELOPMENT
- Sangeeta Hazarika, Pobitra Borah and Pran Kishore Deb
INTRODUCTION
PATHOGENESIS OF RHEUMATOID ARTHRITIS
CONTEMPORARY TREATMENT STRATEGIES AND THEIR LIMITATIONS
HERBAL PRODUCTS: SKEPTICISM
POTENTIAL PLANT-DERIVED PRODUCTS AGAINST RA
- Plant-derived Products in Clinical Trials
- Plant-based Dietary Interventions
- Vegan Diet
- Mediterranean Diet
- Other Supplement Therapy
- Compounds Undergoing Preclinical Development
- Luteolin
- Quercetin
- Genistein
- Piperlongumine
- Kaempferol
- Resveratrol
- Ellagic Acid
- Gallic acid
- Ferulic Acid
- Chlorogenic Acid
- Oxymatrine
- Montanine
- Emodin
- Chebulanin
CONCLUDING REMARKS
REFERENCES
CHAPTER 3 RECENT UPDATES IN NATURAL PRODUCT RESEARCH AND NOVEL APPROACHES TO DRUG DELIVERY USING PHYTOMOLECULES
- Junmoni Nath, Chayanika Bordoloi, Alakesh Bharali, Bhanu P. Sahu and Damiki Laloo
INTRODUCTION
HERBAL DRUG DELIVERY SYSTEM: SCOPE AND CHALLENGES
NOVEL APPROACHES TO DRUG DELIVERY OF PHYTOMOLECULES FOR THERAPEUTIC BENEFITS
PHYTOSOMES
- Methods for Preparation of Phytosomes
- NIOSOMES
- Methods for Preparation of Niosomes
LIPOSOMES
PRONIOSOMES
- Methods of Preparation of Proniosomes
ETHOSOMES
- Methods of Ethosomes Preparation
TRANSFEROSOMES
- Methods of Preparation of Transferosomes
MICROSPHERES
- Advantages of Microspheres
- Methods of Preparation of Microspheres
MICROEMULSIONS
- Advantages of Microemulsions as Drug Carrier
- Nanoemulsions
- Advantages of Nanoemulsions
NANOPARTICLES
- Advantages of Nanoparticles
MARKETED NOVEL DRUG DELIVERY SYSTEM FORMULATIONS BASED ON PLANT EXTRACTS AND ACTIVES
CONCLUSION
REFERENCES
CHAPTER 4 MOLECULAR BASIS OF THERAPEUTIC ACTION OF FLAVONOIDS
- Vimalavathini R., Sittarthan V. and Kavimani S.
INTRODUCTION
- Tannins
- Alkaloids
- Terpenoids
- Saponins
- Phenolic Compounds
CLASSIFICATION OF FLAVONOIDS
PHYSIOLOGICAL ROLES OF PLANT FLAVONOIDS
- Anti-inflammatory Activity
- Anti-cancer Activity
- Anti Diabetic Activity
- Antithrombogenic Effect
- Anti-bacterial Activity
- Metabolism of flavonoids
MOLECULAR BASIS OF PHARMACOLOGICAL ACTIONS OF FLAVONOIDS
- Flavonols
- Kaempferol
- Myricetin
- Quercetin
- Rutin
- Isorhamnetin
- Fisetin
- Flavonone
- Eriodictyol
- Hesperidin
- Naringenin
- Flavone
- Luteolin
- Apigenin
- Baicalein
- Tangeretin
- Anthocyanins
- Flavanonols
- Chalcone
- Isoflavone
- Genistein
- Formononetin
- Biochanin-A
- Flavanol
CONCLUSION
REFERENCES
CHAPTER 5 RESEARCH OUTCOMES OF NATURAL PRODUCTS IN DIABETES MELLITUS
- Subrat Kumar Bhattamisra and Mayuren Candasamy
INTRODUCTION
- Commonly Used Plants with Proven Anti-Diabetic Activity
- Momordica charantia L.
- Panax ginseng
- Allium cepa L.
- Allium sativum L.
- Aloe vera L.
- Pterocarpus marsupium
- Tinospora cordifolia
- Tinospora crispa L.
- Gymnema sylvestre
- Ocimum sanctum L.
- Costus igneus
- Active Constituents with Reported Anti-diabetic Activity
- Anthocyanins
- Berberine
- Catechins
- Curcumin
- Ginsenosides
- Stevioside
CONCLUSION
REFERENCES
CHAPTER 6 EXPLORATION OF PLANT PHYTOMOLECULES’ POTENTIAL FOR ANTIVIRAL ACTIVITY
- Rupesh Kumar Pandey, Sokindra Kumar, Lubhan Singh, Manish Pathak, Ganesh Prasad Mishra, Priyanka Pandey, Gunjan Kalyani, Shiv Shankar Shukla and Ravindra Kumar Pandey
INTRODUCTION
VIRAL DISEASES
- Respiratory System-related Viral Infection
- Gastrointestinal System-related Viral Infection
- Exanthematous Viral Disease
- Metabolic Viral Diseases
- Skin Viral Infections
- Hemorrhagic Viral Infections
- Viral Diseases Related to the Nervous System
INDIAN TRADITIONAL DRUGS
ROLE OF PRIMARY AND SECONDARY METABOLITES
- Bioactive Compounds of Plants and their Pharmacological Activities
CHALLENGES IN PLANT-BASED RESEARCH
FUTURE PROSPECTS OF PLANT-BASED MEDICINE
CONCLUSION
REFERENCES
CHAPTER 7 PRECLINICAL PHARMACOLOGY OF SOME IMPORTANT INDIAN MEDICINAL HERBS IN ANIMAL MODELS AND THEIR MODE OF ACTION
- Manajit Bora, Manish Kumar Gautam, Sejuti Ray Chowdhury, Sharad D. Pawar, Raja Chakraborty, Biswajit Dash, Nilip Kanti Deb, Sandip Mondal and Aniya Teli
INTRODUCTION
PHARMACOLOGICAL ACTIVITY OF MEDICINAL PLANTS
- Aloe barbadensis Mill. (Asphodelaceae)
- Hepato-protective Activity
- Anti-cancer Activity
- Hypoglycemic and anti-hyperlipidemic Activities
- Anti-inflammatory and Analgesic Activity
- Azadirachta indica A. Juss (Meliaceae)
- Anti-diabetic Effect
- Cardiovascular Effects
- Hepato-protective Effect
- Analgesic and Anti-inflammatory Activity
Author
- Raja Chakraborty
- Saikat Sen
