Neuropathology of Aging and Alzheimer’s Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.
Table of Contents
1. Alzheimer's disease: A Fortuitous Beginning2. Alzheimer's First Case
3. Alzheimer's Second Case and the Naming of Alzheimer's Disease
4. Some Early Observations of Alzheimer Contemporaries
5. Early Studies on Senile Dementia and Aging
6. The Human Element
7. The 1920s and 1930s
8. The 1940s to the 1960s
9. Lewy Bodies
10. The Role of Vascular Disease in Alzheimer’s Disease Neuropathology
11. The Rise of the Acronym
12. Age-related Neuronal Tau
13. Aging-related tau astrogliopathy
14. TDP-43 in aging and Alzheimer’s disease
15. Argyrophilic Grain Disease
16. Introduction to the Traumatic Brain Injury-Neurodegenerative Disease Dichotomy
17. Punch Drunk Syndrome: The First 30 Years
18. Pathology Studies from the 1950s and 1960s; the Roberts Study
19. 1970's to 2000's: Transitioning to an Immunohistochemistry-Only Diagnosis
20. The modern CTE era
21. Postmortem of Punch Drunk Boxers and CTE
22. Familial Alzheimer’s disease and Down Syndrome
23. The modern CTE era
24. Application of consensus criteria
25. The Diagnostic Process
