Targeted Protein Degradation Technologies provides a thorough overview of targeted protein degradation from the latest developments in the field to potential therapeutic applications. The book begins with an introduction to the mechanisms of protein degradation followed by a section covering both protease-mediate degradation and lysosome-mediate degradation. A range of cutting-edge technologies are covered, including PROTAC, AbTAC, molecular glues, hydrophobic tagging, LYTAC, GlueTAC and AUTAC. Degraders of specific proteins are then investigated, including signal transduction receptors, membrane proteins, and transcription factor degraders. The book closes with a section on the clinical applications of targeted protein degradation and a look at future perspectives. It is a useful resource to those in the fields of molecular biology, cell biology, and related areas working with protein degradation and the development of therapeutic technologies in this arena.
Table of Contents
Part 1: Introduction 1. Mechanisms of protein degradation 2. Overview of targeted protein degradation Part 2: Summary of targeted protein degradation 3. Protease-mediate degradation 4. PROTAC 5. AbTAC 6.? Molecular glues 7.? Hydrophobic tagging technology 8. Lysosome-mediate degradation 9. LYTACs 10.? Bispecific Apt amer Chimera (BIAC) 11. ?GlueTAC 12. AUTACs 13. ATTECs 14. AUTOTAC Part 3:? Degradation of Proteins?of Interest 15. Degraders of signal transduction receptors 16. Degraders of membrane-associated proteins 17. Degraders of cell cycle- and anti-apoptosis-related proteins 18.? Degraders of proteins in epigenetic regulation 19. Degraders of proteins involved in transcription nuclear hormone receptors 20. Transcription factor degraders Part 4: Clinical applications of targeted protein degradation 21. Clinical development of protein degraders
