Table of Contents
1. Introduction2. Biosynthesis and metabolism of bradykinin
3. Bradykinin receptors and their signalling pathways
4. Animal models for studying bradykinin receptors
5. Peptide and non-peptide ligands acting at bradykinin receptors
6. Bradykinin in angioedema
7. Bradykinin and its receptors in inflammation
8. Bradykinin in Pain
9. Bradykinin in cardiovascular and renal diseases
10. Bradykinin in hypertension and heart failure
11. Bradykinin and its receptors in neovascularisation
12. Bradykinin in diabetes and obesity
13. Bradykinin in ocular diseases
14. Bradykinin agonists as a mean to increase blood-brain barrier permeability
15. Bradykinin as a central mediator
16. Bradykinin in infectious and parasitic diseases
17. Bradykinin in cancer
Authors
R�jean Couture Professor, Department of Pharmacology and Physiology, Faculty of Medicine, Universit� de Montr�al, Canada.R�jean Couture is currently Full Professor at the Department of Pharmacology and Physiology at the Faculty of Medicine, Universit� de Montr�al in Canada. After completing a PhD in Pharmacology at University of Sherbrooke, Canada, he was awarded Fellowship Awards from the Medical Research Council of Canada (MRC) and the Fonds de la recherche en sant� du Quebec (FRSQ) to pursue postdoctoral trainings in Pharmacology at Oxford University and in Neuroscience at McGill University.
He is the author of over 225 original articles, books and book chapters, including 90 directly on kinins. He has supervised close to 60 graduate and postdoctoral students, many of whom now hold significant academic and other positions throughout Canada and internationally.
He is known internationally for his seminal contributions in the field of Bradykinin and Substance P in pain and inflammation and in central autonomic control of blood pressure.
