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Role of Sex and Gender in Aging and Longevity

  • Book

  • July 2025
  • Elsevier Science and Technology
  • ID: 6042190
Role of Sex and Gender in Aging and Longevity aims to shed light on the complex interplay between sex and gender differences in the aging process and longevity of individuals. While biological sex differences have long been recognized as influencing various aspects of aging, this book includes how gender also plays a significant role in shaping these processes, accelerating aging, or favoring longevity. By acknowledging the influence of both biological and socially constructed factors, this book offers a comprehensive understanding of why individuals may experience different aging trajectories and have divergent longevity outcomes.

This book explores the intricate ways in which gender norms, roles, and expectations shape individual experiences of aging and delves into the social determinants of health that can interact with biological factors to influence the aging process and longevity outcomes. By examining these interactions, the book aims to provide a nuanced understanding of the multifaceted nature of aging and longevity and how sex and gender contribute to these complex phenomena.

Table of Contents

1. Introduction
2. Demographic Aspects of Longevity
3. Sex and Genetics of Longevity
4. Sex, Gender, and Epigenetics of Aging and Longevity
5. The Role of Sex, Gender in the Oxidative Stress in Successful and Unsuccessful Aging
6. Gender Medicine: the Case of Oncology
7. Exposome, Aging, and Longevity: the Role of Sex and Gender Differences in Health and Mortality
8. The Role of Sex and Gender in the Pro-inflammatory Status in Aging and Longevity
9. Immune Aging of Men and Women: Different Susceptibility to Infectious Diseases and Different Response to Vaccines
10. Sex and Gender influence on Autoimmune Diseases of Older People
11. Sex and Gender-linked Differences of Allergic Diseases in Older People
12. Sex and Gender Biomarker Approach: A New Prospective for Age-related Diseases
13. The Role of Sex, Gender in Age-related Neurodegeneration
14. Cardiovascular Diseases: Role of the Sex and Gender
15. Endocrine Disorders in Male and Female Older People
16. The Health-survival Paradox: Women Live Longer But Are Frailer
17. Pathobiology of Aging
18. Laboratory Parameters in Male and Female Older People and Centenarians
19. Lifestyle and Successful Aging in Men and Women
20. Conclusion

Authors

Calogero Caruso Professor Emeritus, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy. Calogero Caruso is Professor Emeritus in the Department of Biomedicine, Neurosciences and Advanced Diagnostics at the University of Palermo. He has authored over 415 papers, mostly on ageing, age-related diseases, and longevity. He was founder and editor in chief of Immunity & Ageing from 2004 to 2018, Coordinator of the PhD program in Molecular Medicine and Biotechnology (formerly Pathobiology) from 1998-2018, and National Coordinator of Italian Ministerial Project on Centenarians and Longevity from 2016-2019. Finally, with Prof. Giuseppina Candore he is responsible for the local unit of the project "Improved Vaccination Strategies for Older Adults (ISOLDA)� funded by the European Commission. The national and international recognition of his scientific achievements in the field of Biogerontology is documented by funded projects, by the number of citations of his papers, by invitations to national and international congresses and meetings, by his activity as a project reviewer and by organization of international conferences.