Pharmacological Targets in Metabolic Diseases. Challenges and Opportunities

Table of Contents

Part I Molecular level
1. Molecular and cellular targets in the management of metabolic diseases and disorders: an overview
2. Redox biology, metabolic disorders and therapeutic opportunities
3. NADPH oxidase, obesity and metabolic syndrome: therapeutic opportunity
4. NAPDH oxidase and diabetes mellitus: therapeutic strategies
5. Targeting reactive carbonyls in metabolic disorders
6. Antioxidant supplementation and metabolic disorders
7. Modulation of the immune system as a pharmacological target in metabolic diseases

Part II Subcellular and cellular levels
8. Modulation of mitochondrial physiology in the prevention and management of metabolic disorders
9. Targeting autophagy in metabolic diseases
10. Endoplasmic reticulum as a pharmacological target in metabolic diseases
II. Subsection: Organs as pharmacological targets in metabolic diseases and disorders
11. The gut-brain axis as a pharmacological target in metabolic diseases
12. Cardiomyopathy in metabolic diseases: pharmacological strategies
13. The cardio-renal-metabolic connection as a pharmacological target
14. Adipose tissue and metabolic diseases: a target for prevention and treatment of metabolic diseases
15. Diabetic kidney disease: treatment and challenges
16. Fatty liver disease: a therapeutical approach
17. Pharmacologic intervention of nonalcoholic steatohepatitis and related cirrhosis

Part III Subsection: Diabetes mellitus
18. Pharmacological management of diabetes mellitus complications

Part IV Subsection: Obesity
19. Pharmacological targets in obesity
20. Diet, obesity, and methylglyoxal: therapeutic opportunities
21. Obesity-related dyslipidemia: pharmacological targets and opportunities

Part V Subsection: Metabolic syndrome
22. Metabolic syndrome: pharmacological strategies and challenges
23. Pharmacological targets in metabolic syndrome-related dyslipidemia
24. Therapeutic intervention in metabolic syndrome: present status and perspectives

Part VI Subsection: Inborn errors of metabolism
25. Fatty acid oxidation disorders: a pharmacological approach
26. Pharmacological treatment of phenylketonuria
27. Pharmacological targets in inborn errors of metabolism in adult patients

Part VII Subsection: Natural molecules and metabolic diseases and disorders
28. Polyphenols and obesity: molecular targets and therapeutic potential
29. Plant molecules and diabetes mellitus: prevention and management
30. Molecular targets in dyslipidemia: therapeutic potential of plant molecules
31. Polyphenols and modulation of cholesterol metabolism
32. Polyphenols and the control of immunometabolism as a pharmacological target

Part VIII Subsection: Microbiota and metabolic diseases and disorders
33. Microbiota, metabolic disorders and pharmacological opportunities
34. Plant extracts/molecules in obesity and the gut microbiota
35. Microbiome/microbiota and diabetes mellitus: pharmacological opportunities and challenges
36. Microbiome/microbiota and fatty liver disease: potential candidate for therapeutic intervention

Part IX Subsection: Aging
37. Aging, metabolic disorders and the mitochondria: pharmacological opportunities

Part X Subsection: Nanotechnology and metabolic diseases and disorders
38. Nanotechnology-related strategies for the prevention of metabolic syndrome

Part XI Subsection: Metabolic diseases and disorders and the environment
39. Environmental pollution and metabolic diseases: a pharmacological challenge

Part XII Subsection: Diagnostic of metabolic diseases and disorders
40. Diagnostic techniques in metabolic diseases and disorders

Authors

Marcos Roberto de Oliveira Professor, Department of Biochemistry, Federal University of Rio Grande do Sul, Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ci�ncias B�sicas da Saude (ICBS), Departamento de Bioqu�mica, Rua Ramiro Barcelos, Brazil. Dr Oliveira PhD earned his bachelor's degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a Master's and a Ph.D. in Biochemistry from the same institution. His research focuses on the neuroprotection mediated by natural molecules and involves studies on mitochondrial physiology, redox biology, bioenergetics, and inflammation in both in vitro and in vivo experimental models.

Dr Oliveira has published numerous articles on peer-reviewed Journals, including Molecular Neurobiology, Chemico-Biological Interactions, Biotechnology Advances, and Oxidative Medicine and Cellular Longevity. He has also edited a book on the effects of plant molecules on the mitochondria Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Health and a book on the role of mitochondrial dysfunction in both neurological disturbances and intoxication Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine.