The book is divided into six sections, starting with the fundamentals of aging and the effects of intermittent fasting. Subsequent sections examine its physiological impact on aging, influence on stress resistance, heart, gut, and overall health optimization. The book also discusses social and ethical considerations, bridging research findings and clinical practice, and the potential integration of intermittent fasting into the treatment of age-related diseases. It provides a consolidated and scientifically grounded perspective, equipping readers with a balanced understanding of the topic.
Table of Contents
I: Fundamentals of Aging and Intermittent Fasting1. Unlocking the Potential: Intermittent Fasting's Impact on Age-related Diseases and Mechanistic Insights.
2. Chronobiology and Circadian Rhythms: Influence on Aging and Disease
3. Cellular Autophagy and Aging: Role in IF-induced Health Benefits
II: Physiological Impact of Intermittent Fasting on Aging
4. Metabolic Health and Intermittent Fasting: Implications for Age-related Disorders
5. Neurological Aging: Neuroprotective Effects of Intermittent Fasting
6. Inflammation, Immunity, and IF: Modulating Age-related Inflammatory Processes
7. Epigenetic Modifications and Aging: IF as a Catalyst for Positive Epigenetic Changes
8. Mitochondrial Health and Longevity: IF's Impact on Cellular Energy Production
III: Therapeutic Applications of Intermittent Fasting in Aging
9. Hormesis and Adaptive Responses: IF-induced Stress Resistance and Disease Resilience
10. Cardiovascular Aging and IF: Implications for Heart Health and Vascular Function
11. Gut Microbiota and Aging: IF's Influence on Gut-Brain Axis and Systemic Health
12. Precision Nutrition and Personalized IF: Tailoring Therapeutics for Optimal Aging
IV: Social and Ethical Considerations of Intermittent Fasting in Aging
13. Ethical Considerations of IF in Aging: Balancing Health Benefits and Societal Impacts
V: Bridging Research and Practice in Intermittent Fasting for Aging
14. Translating IF Research into Clinical Practice: Challenges and Opportunities
15. Interplay Between Diet, Exercise, and Intermittent Fasting in Metabolic Disease Reduction in People with Obesity and Promoting Healthy Aging
16. Interplay Between Diet and Exercise for Healthy Aging and Managing Age-related Lifestyle Diseases
17. Future Directions in IF and Aging Research: Unexplored Avenues and Collaborative Efforts
VI: Clinical Applications of Intermittent Fasting in Aging-related Diseases
18. Integrating Intermittent Fasting into Clinical Practice for Diverse Diseases
19. IF as Complementary Therapy in Aging-linked Diseases
Authors
Jitendra Kumar Sinha Chief Scientific Officer at GloNeuro Academy, Noida and Neuroscience; Visiting Faculty at Jiwaji University, Gwalior, India.Dr. Jitendra Kumar Sinha, PhD, is the Chief Scientific Officer at GloNeuro Academy, Noida and Neuroscience Visiting Faculty at Jiwaji University, Gwalior, India. His research interests include the neurobiology of aging and obesity, nutritional neuroscience, anti-aging paradigms and neuropharmacology. He has over 16 years experience in research and education, including high level course development and mentorship. He has a long-standing interest in animal models of aging and epilepsy, with focus on oxidative protein damage, DNA damage, and aging biomarkers, and notably established the heaviest rodent model for studying molecular mechanism of enhanced aging. Dr. Sinha has authored over 70 publications in several leading journals on aging, epilepsy, obesity, sleep, and spinal cord injury. He has served as guest editor, referee, or member of the editorial board for over 25 journals and received various prestigious awards from Government of India, International Brain Research Organization, International Society for Neurochemistry, among others.
Raviraja N Seetharam Manipal Academy of Higher Education, India.Dr Raviraja N Seetharam, PhD, MBA, is an outstanding scientist and business development professional having more than 25 years of research experience in diverse areas of biology/biopharma. Dr Ravi joined MEMG group company, Stempeutics Research, in 2010 and served for ten years as centre head. In April 2020, he joined Manipal Academy of Higher Education (MAHE) as the founding Director of Corporate Relations and established that vertical until June 2023. In March 2023, he became the Director of Planning and Monitoring, MAHE. He was instrumental in establishing Manipal Centre for Biotherapeutics Research, MAHE, envisioning the development of new generation of biotherapeutics. He currently serves as Professor and Coordinator of Manipal Centre for Biotherapeutics Research, MAHE, Manipal, where his research primarily focuses on the area of stem cells and other biotherapeutics. He has more than 70 research papers and 5 patents to his credit.
Abhishek Kumar Singh Associate Professor, Manipal Centre for Biotherapeutics Research (MCBR), Manipal Academy of Higher Education (MAHE), India.Dr. Abhishek Kumar Singh, PhD, is Associate Professor at Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, Manipal, Karnataka, India. He has over fifteen years research experience in the neurobiology of aging using multiple model systems. His primary research investigates the interplay between autophagy and pro-survival pathways during the aging of the brain and aging-induced neurodegenerative disorders, particularly Alzheimer's disease. Additionally, he develops caloric restriction mimetics-based strategies to slow down brain aging to improve health span and lifespan. Dr. Singh has published more than 50 research articles in international journals of high repute, edited two books, and contributed to over fifteen book chapters in international publications. Dr. Singh currently serves as Academic Editor of PLOS One and guest editor and referee for more than 10 journals. He is life member of various international scientific societies, including the Indian Academy of Neuroscience and Society of Toxicology India.
