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2024 DNA and RNA Synthesis Research Review

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    Report

  • 184 Pages
  • March 2025
  • Region: Global
  • BCC Research
  • ID: 6059441
DNA and RNA synthesis technology is vital in scientific fields such as synthetic biology, molecular genetics, and bioengineering, creating custom DNA and RNA sequences for various research, diagnostic, and therapeutic applications. The rapid expansion of genomics research, advancements in therapeutic DNA and RNA applications, and the growing need for personalized medicine are driving exceptional growth in the DNA & RNA synthesis market. The innovations in CRISPR, gene therapy, and synthetic biology show that the demand for DNA and RNA synthesis has risen sharply, positioning it as a pivotal tool in developing targeted treatments and innovative genetic research solutions.
  • The global market for DNA sequencing is expected to grow from $14.8 billion in 2024 and is projected to reach $34.8 billion by the end of 2029, at a compound annual growth rate (CAGR) of 18.6% during the forecast period of 2024 to 2029.
  • The global market for clinical applications of next-generation sequencing is estimated to increase from $21.9 billion in 2023 to reach $52.9 billion by 2028, at a CAGR of 19.3% from 2023 through 2028.
  • The global market for RNA sequencing is expected to grow from $4.3 billion in 2024 and is projected to reach $10.3 billion by the end of 2029, at a CAGR of 19.1% during the forecast period of 2024 to 2029.

Research Review Scope

DNA and RNA synthesis artificially manufactures deoxyribose nucleic acid (DNA) and ribonucleic acid (RNA). Developing synthetic techniques to construct DNA and RNA has improved the ability to understand and engineer biology. Different types of synthesized DNA, such as oligonucleotides, genes, and DNA and RNA fragments, are available and can be utilized per the customer's needs. Synthetic DNA and RNA are used to develop new drugs and vaccines, gene therapies for genetic disorders, and the development of molecular diagnostic tools, including polymerase chain reaction (PCR) assays and nucleic-acid-based sensors, to detect pathogens and diseases.

Table of Contents

Chapter 1 Foreword
  • Research Review Scope
Chapter 2 Gene Editing Therapeutics Market (BIO259A)
  • Scope of Report of Gene Editing Therapeutics
  • Market Outlook of Gene Editing Therapeutics
  • Market Summary
  • Market Overview of Gene Editing Therapeutics
  • Genome-Editing Tool Types
  • Meganucleases
  • Zinc Finger Nucleases
  • Transcription Activator-like Effector Nucleases
  • Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-Associated Protein 9
  • Gene editing Therapeutics
  • Market Dynamics of Gene Editing Therapeutics
  • Market Driver
  • Market Challenges
  • Emerging Technologies and Opportunities of Gene Editing Therapeutics
  • Base Editing
  • Prime Editing
  • Cas-Clover and Cas-FOKl
  • CRISPR Interference and CRISPR Activation
  • RNA Editing
  • Artificial Intelligence in Genome Editing
  • Market Analysis of Gene Editing Therapeutics
  • Overview
  • Casgevy
  • Market of Gene Editing Therapeutics by Region
  • North America
  • Europe
  • Emerging Markets
  • ESG Performance in Gene Editing Therapeutics Market
  • ESG Practices in the Gene Editing Companies
  • Concluding Remarks
Chapter 3 Global DNA Sequencing: Research, Applied and Clinical Markets (BIO045J)
  • Scope of Report of DNA Sequencing: Research, Applied and Clinical Markets
  • Market Outlook of DNA Sequencing: Research, Applied and Clinical Markets
  • Market Summary of DNA Sequencing: Research, Applied and Clinical Markets
  • Market Overview of DNA Sequencing: Research, Applied and Clinical Markets
  • Importance of DNA
  • Genetic Variation and Analysis
  • NGS (Second-generation Sequencing)
  • TGS (Long-read Sequencing)
  • Research and Applied Applications
  • R&D Applications
  • Applied Applications
  • Direct to Consumer
  • Biopharma
  • Agriculture
  • Forensics
  • Microbiome
  • Synthetic Biology
  • Market Dynamics of DNA Sequencing: Research, Applied and Clinical Markets
  • Market Driver
  • Market Restraint
  • Emerging Technologies of DNA Sequencing: Research, Applied and Clinical Markets
  • Long-read Sequencing Technologies
  • SMRT Sequencing
  • Nanopore Sequencing
  • Spatial Genomics and Transcriptomics
  • Single-cell DNA Sequencing
  • Ultra-low Input Sequencing
  • CRISPR-Cas9 and Genome-editing Integration with Sequencing Technologies
  • AI and Machine Learning in DNA Sequencing
  • Market Breakdown of DNA Sequencing: Research, Applied and Clinical Markets by Technology
  • Overview
  • NGS
  • TGS
  • Sanger Sequencing
  • Pyrosequencing
  • Market Breakdown of DNA Sequencing: Research, Applied and Clinical Markets by Region
  • North America
  • Europe
  • Asia-Pacific
  • Rest of the World
  • ESG Performance in DNA Sequencing Industry
  • Environmental Performance
  • Social Performance
  • Governance Performance
  • ESG Risk Ratings in the DNA Sequencing Industry
  • Concluding Remarks
Chapter 4 Next-generation Sequencing: Emerging Clinical Applications and Global Markets (BIO126E)
  • Scope of Report of Next-generation Sequencing
  • Market Outlook of Next-generation Sequencing
  • Market Summary of Next-generation Sequencing
  • Market Overview of Next-generation Sequencing
  • Liquid and Tissue Biopsy
  • Growth Drivers of Clinical NGS
  • Key Trends
  • Market Dynamics of Next-generation Sequencing
  • Market Driver
  • Market Restraint
  • Emerging Technologies of Next-generation Sequencing
  • R&D Initiatives and Programs
  • 1+ Million Genomes
  • Access to Treatment and Testing (ACTT)
  • Access to Comprehensive Genomic Profiling Coalition (ACGP)
  • Africa Pathogen Genomics Initiative
  • Blood Profiling Atlas
  • Cancer-ID
  • Cancer Moon Shots Program
  • China Precision Medicine Initiative
  • ClinGen
  • CTC Trap Consortium
  • diaRNAgnosis Project
  • Early Cancer Detection Consortium
  • EpiFemCare
  • France Genomic Medicine Plan
  • Friends of Cancer Research Project
  • Genomic Medicine Sweden
  • HCA-Organoid
  • Human Cell Atlas
  • Human Immunomics Initiative
  • Immunomonitor Consortium
  • Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy Program
  • Intervene
  • Liquid Biopsies and Imaging for Improved Cancer Care
  • Liquid Biopsy-Based Malignant Tumor Early Screening Technology Research and Development Project
  • Liver Cancer Early Screening Comprehensive Prevention and Control Project
  • Lung Cancer Genomic Screening Project for Individualized Medicine in Asia
  • Million Veteran Program
  • Medical Genome Initiative
  • MedSeq
  • Market Breakdown of Next-generation Sequencing by Disease Category
  • Overview
  • Market Breakdown of Next-generation Sequencing by Region
  • North America
  • Europe
  • Asia-Pacific
  • ESG Performance in Next-generation Sequencing Industry
  • Case Study
  • BCC Research Viewpoint
Chapter 5 RNA Sequencing: Technologies and Global Markets (BIO147B)
  • Scope of Report of RNA Sequencing
  • Market Outlook of RNA Sequencing
  • Market Summary of RNA Sequencing
  • Market Overview of RNA Sequencing
  • Technology Background
  • Transcriptomics Technologies
  • RNA Sequencing for Transcriptomics
  • RNA-Seq Experimental Workflow
  • Regulatory Landscape of RNA Sequencing
  • Growth Strategy Recommendations
  • Market Dynamics of RNA Sequencing
  • Market Drivers
  • Market Restraints
  • Market Opportunity
  • Emerging Technologies and Developments of RNA Sequencing Market
  • Single-Cell RNA Sequencing
  • Other Emerging Single-Cell Technologies
  • Market Breakdown of RNA Sequencing by Product
  • Instruments
  • Tools and Reagents
  • Software and Services
  • Market Breakdown of RNA Sequencing by Region
  • Overview
  • North America
  • Europe
  • Asia-Pacific
  • Rest of the World
  • Sustainability in RNA Sequencing Market: ESG Perspective
  • ESG Practices in the RNA Sequencing Industry
  • Environmental Performance
  • Social Performance
  • Governance Performance
  • Concluding Remarks
Chapter 6 RNAi Technologies and Global Markets ( BIO127C)
  • Scope of Report of RNAi Technologies
  • Market Snapshot of RNAi Technologies
  • Market Summary of RNAi Technologies
  • Market Overview of RNAi Technologies
  • RNA Interference Overview
  • RNA Interference: Mechanism of Action
  • Initiation Phase
  • Effector Phase
  • Small Interfering RNAs (siRNAs)
  • MicroRNAs (miRNAs)
  • Small Hairpin RNAs (shRNAs)
  • Market Dynamics of RNAi Technologies
  • Market Drivers
  • Market Challenges
  • Emerging Technologies and Opportunities of RNAi Technologies
  • Therapeutics
  • Diagnostics
  • Circulating miRNA Diagnostics for Non-invasive Health Monitoring
  • Agriculture
  • Market for RNAi Technology by Technology
  • Therapeutics
  • Diagnostics
  • Reagents and Tools
  • Agriculture
  • Market for RNAi Technology by Region
  • Overview
  • North America
  • Europe
  • Emerging Markets
  • Sustainability in RNAi Technology Industry: An ESG Perspective
  • Environmental Initiatives
  • Social Initiatives
  • Governance Initiatives
  • Case Study
  • Concluding Remarks
Chapter 7 Viral Vector and Plasmid DNA: Technologies and Global Markets (BIO192B)
  • Scope of Report of Viral Vector and Plasmid DNA
  • Market Outlook of Viral Vector and Plasmid DNA
  • Market Summary of Viral Vector and Plasmid DNA
  • Market Overview of Viral Vector and Plasmid DNA
  • Cell and Gene Therapy
  • Market Dynamics of Viral Vector and Plasmid DNA
  • Market Driver
  • Market Challenges
  • Emerging Technologies and Opportunities of Viral Vector and Plasmid DNA
  • AI in Viral Vector Production
  • Doggybone DNA
  • FRAGment Recycler: A New Technology for Plasmid DNA Synthesis
  • Market for Viral Vector and Plasmid DNA Technologies by Product Type
  • Market for Viral Vector and Plasmid DNA Technologies by Application
  • Market for Viral Vector and Plasmid DNA Technologies by Region
  • Overview
  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • Rest of the World
  • Sustainability in the Market for Viral Vector and Plasmid DNA Technologies: An ESG Perspective
  • Environmental Factors
  • Social Factors
  • Governance Factors
  • ESG Performance Among Major Companies
  • ESG Performance of Select Companies
  • Lonza: ESG Performance
  • Thermo Fisher: ESG Performance
  • Conclusion
Chapter 8 Appendix
  • Methodology
  • Analyst’s Credentials
List of Tables
Table 1: Global Market for Gene Editing Therapeutics, Through 2029
Table 2: Comparison of Genome-Editing Tools
Table 3: U.S. Adults Age 50 Years and Older with Multiple Chronic Conditions, 2020-2050
Table 4: Global Cases and Deaths Due to Various Cancers, 2022
Table 5: Comparison of Cas9-derived Proteins with Regular SpCas9
Table 6: Global Market for Gene Editing Therapeutics, Through 2029
Table 7: Global Market for Gene Editing Therapeutics, by Region, Through 2029
Table 8: ESG Initiatives/Practices by Various Gene Editing Companies, 2023
Table 9: ESG Rankings for Companies in the Gene Editing Therapeutics Market, 2023
Table 10: Global DNA Sequencing Market, by Region, Through 2029
Table 11: DNA Transcription and Translation
Table 12: Types of Genetic Variation
Table 13: Molecular Diagnostic Technology Platforms
Table 14: Main Sequencing Applications
Table 15: Genetic Analysis Platform Comparison
Table 16: Key Applications in Microbial Sequencing
Table 17: Global DNA Sequencing Market, by Technology, Through 2029
Table 18: Different Generations of NGS Platforms
Table 19: Global DNA Sequencing Market, by Region, Through 2029
Table 20: Environmental Performance Initiatives in the DNA Sequencing Market
Table 21: Social Performance Initiatives in the DNA Sequencing Market
Table 22: Governance Performance Initiatives in the DNA Sequencing Market
Table 23: ESG Rankings for Key Players in DNA Sequencing Market, 2024*
Table 24: Global Market for Clinical Applications of Next-Generation Sequencing, by Disease Class, Through 2028
Table 25: Forces Influencing Growth in the Clinical NGS Market
Table 26: Key Trends in the Clinical NGS Testing Market
Table 27: Future Challenges in Implementing Clinical NGS
Table 28: Clinical NGS Research and Development Initiatives and Programs
Table 29: Global Market for Clinical NGS, by Disease Category, Through 2028
Table 30: Global Market for Clinical NGS, by Region, Through 2028
Table 31: Key Focus Areas in ESG Metrics
Table 32: ESG Rankings for Major Companies in the NGS Arena
Table 33: Illumina 2030 ESG Targets
Table 34: Global Market for RNA Sequencing, by Product, Through 2029
Table 35: Global Market for RNA Sequencing, by Technology, Through 2029
Table 36: Types of RNAs in Cells
Table 37: Comparison of Transcriptomics Methods
Table 38: Functional Elements in Sequencing Adapters
Table 39: Overview of Illumina’s Sequencing Instruments
Table 40: Cloud Computing Providers for Genomics/RNA-Seq
Table 41: Global Market for RNA Sequencing, by Region, Through 2029
Table 42: Research Initiatives Focused on Personalized Medicine in Europe
Table 43: Key Focus Areas in ESG Metrics
Table 44: Environmental Performance Initiatives in the RNA Sequencing Market
Table 45: Social Performance Initiatives in the RNA Sequencing Market
Table 46: Governance Performance Initiatives in the RNA Sequencing Market
Table 47: ESG Rankings for Key Players in RNA Sequencing Market, 2024*
Table 48: Global Market for RNAi Technology, by Technology Type, Through 2029
Table 49: Cost Comparison of siRNA-approved Drugs and Alternative Therapies
Table 50: Global Market for RNAi Technology, by Technology Type, Through 2029
Table 51: RNAi Approved Drugs List
Table 52: miRNA-based Diagnostic Tools Available in Clinical Settings
Table 53: Global Market for RNAi Technology, by Region, Through 2029
Table 54: Key Focus Areas in ESG Metrices
Table 55: Environmental Initiatives, by Various RNAi Technology Companies
Table 56: ESG Rankings for Companies in the RNAi Technology Market, 2023
Table 57: Alnylam’s ESG initiatives
Table 58: Global Market for Viral Vector and Plasmid DNA Technologies, by Product Type, Through 2028
Table 59: Global Incidence of All Cancers, by WHO Region, 2022-2050
Table 60: Global Market for Viral Vector and Plasmid DNA Technologies, Through 2028
Table 61: Global Market for Viral Vector and Plasmid DNA Technologies, by Product Type, Through 2028
Table 62: Global Market for Viral Vector and Plasmid DNA Technologies, by Application, Through 2028
Table 63: Global Market for Viral Vector and Plasmid DNA Technologies, by Region, Through 2028
Table 64: ESG Rankings of Major Companies, 2024*
Table 65: Lonza: ESG Performance
Table 66: Thermo Fisher: ESG Performance
List of Figures
Figure 1: Global Market for Gene Editing Therapeutics, 2021-2029
Figure 2: Emerging Technologies in the Genome-Editing Therapeutics Market
Figure 3: Global DNA Sequencing Market Shares, by Region, 2023
Figure 4: Global Market Shares of DNA Sequencing, by Technology, 2023
Figure 5: Global DNA Sequencing Market Shares, by Region, 2023
Figure 6: Global Market for Clinical Applications of Next-Generation Sequencing, by Disease Class, 2020-2028
Figure 7: Key Sustainable Practices Being Implemented in Research Laboratories
Figure 8: Global Market for RNA Sequencing, by Product, 2021-2029
Figure 9: Global Market for RNA Sequencing, by Technology, 2021-2029
Figure 10: RNA-Seq Experiments for Transcriptomics
Figure 11: RNA-Seq Experimental Workflow
Figure 12: Growth Strategy Recommendations: RNA Sequencing Market
Figure 13: Average Cost Per Genome: Y-o-Y Trend, 2011-2022
Figure 14: Global Market Shares of RNA Sequencing, by Product, 2024
Figure 15: Global Market Shares of RNA Sequencing, by Region, 2024
Figure 16: Growth Drivers in Asia-Pacific RNA Sequencing Market
Figure 17: Global Market for RNAi Technology, by Technology Type, 2021-2029
Figure 18: Global Market Shares of RNAi Technology, by Technology Type, 2023
Figure 19: Global Market for RNAi Technology, by Region, 2021-2029
Figure 20: Global Market Shares of RNAi Technology, by Region, 2023
Figure 21: Global Market for Viral Vector and Plasmid DNA Technologies, by Product Type, 2020-2028
Figure 22: Global Market Shares of Viral Vector and Plasmid DNA Technologies, by Product Type, 2022