Regenerative Medicines: Bone and Joint Applications

The report explains critical trends in the regenerative medicine industry. It discusses the market determinants, which act as motivating or restraining factors, and provides insights to stakeholders and potential entrants.

This study looks at most of the systems affected by factors such as R&D spending and increasing competition and new technologies.

This report also covers merger and acquisition strategies and collaborations, as well as the strengths and weaknesses of each strategy type.

The market has also been analyzed based on regenerative medicine for bone and joint applications. Categories considered in this report include allogeneic bones, autogenic bones, bone graft substitutes, osteoarticular diseases, and others.

The report provides information to all market players, potential entrants, government agencies, and other interested parties. As the report covers geographic regions in detail, companies interested in expanding their geographic reach will also find this study useful.

Report Includes

36 data tables and 30 additional tables
An up-to-date review and in-depth assessment of the global markets for regenerative medicine in bone and joint applications
Analyses of the global market trends, with historical market revenue data (sales figures) for 2020-2022, estimates for 2023, and projections of compound annual growth rates (CAGRs) through 2028
Estimation of the actual market size and revenue forecast for regenerative medicine for bone and joint applications market, and corresponding market share analysis based on the type of technology, application, and region
Highlights of the importance of biomaterials, stem cell therapy, tissue engineering, and emerging/upcoming technologies (including bioprinting) in the regenerative medicine industry, along with the long-term impacts of regenerative medicine technologies, both existing and in developmental stage
Country specific data analysis and market growth forecasts for the U.S., Canada, Germany, the UK, France, Italy, Russia, Spain, Australia, Japan, China and India
Discussion of major growth drivers and restraints, technology advancements, product innovations and regulatory aspects that will shape the market for regenerative medicine for bone and joint applications as a basis for projecting demand in the next few years (2023-2028)
Identification of the companies best positioned to meet this demand owing to or in conjunction with their proprietary technologies, product launches, and other strategic advantages
Holistic review of the impact of COVID-19 and other economic and demographic factors affecting the market growth in the analysis period
A relevant patent analysis with the number of patents registered/approved, ongoing industry clinical trials, and recent mergers, acquisitions, and collaboration agreements in the regenerative medicine industry
Insight into the recent industry structure, competitive aspects of each product segments, increasing investment on global R&D activities, market growth strategies, and company revenue share analysis
Identification of leading and emerging competitors in the global regenerative medicine market, and analysis of competitive landscape based on recent developments and segmental revenues
Company profiles descriptions of the major market players, including Smith & Nephew Plc, DePuy Synthes, Medtronic plc, Stryker Corp., Bioventus, Zimmer Biomet, Anika Therapeutics, Baxter Intl., and CONMED Corp.

Chapter 1 Introduction

Background
Study Goals and Objectives
Reasons for Doing this Study
What's New in this Update?
Scope of Report
Information Sources
Research Methodology
Geographic Breakdown
Analyst's Credentials
Custom Research
Related Research Reports

Chapter 2 Summary and Highlights

Chapter 3 Market and Technology Background

Overview of Regenerative Medicine
How Regenerative Medicine Works?
Principal Approaches to Regenerative Medicine
Cells and Tissues
Tissue Engineering
Importance of Scaffolding in Tissue Engineering
Plastic Scaffolding
Blood Vessel Scaffolding
Center for Integration of Medicine and Innovative Technology (Cimit)
Embryonic Stem Cells

Chapter 4 Emerging/Upcoming Technologies in the Market

Emerging Technologies in Regenerative Medicines for Bones and Joint Applications
Nanomaterials and Regenerative Medicine in Orthopedic Surgery
Regeneration Therapy Using Stem Cells and Nanometer Technology
Nanostructured Cartilage Tissue Engineering
Bone Tissue Engineering
Tendon Tissue Engineering
Adipose Tissue
Platelet-Rich-Plasma (Prp)
Bioprinting Technologies for Construction of Multicellular/Multi-Material Tissues
Scaffolding Option in Tissue Engineering
Hydrogel Scaffold
Solid Scaffold
Future Opportunities

Chapter 5 Market Dynamics

Market Drivers
Growing Number of Bone and Joint Disorders and Orthopedic Surgeries
Increasing Expenditures for Health Care and Investments in Regenerative Medicines
Increasing Geriatric Population
Increasing Product Approvals and Launches
R&D for Stem and Gene Therapies
Market Restraints
Stringent Government Regulatory Settings in R&D
Market Opportunities
Growing Pipeline for Regenerative Medicines
Covid-19 Impact Analysis
Impact of Covid-19 on the Market for Cell and Gene Therapies and Regenerative Medicine for Bone and Joint Applications
Direct Impact on Clinical Trials in Cell and Gene Therapy
Post-Covid-19 Effect on Regenerative Medicine for Bones and Joint Applications

Chapter 6 Market Breakdown by Technology

Global Market, by Technology
Biomaterials
Biomaterials for Regeneration
Market Size and Forecast
Tissue Engineering
Market Size and Forecast
Stem Cell Therapy
Market Size and Forecast

Chapter 7 Market Breakdown by Application

Global Market, by Application
Allogeneic Bones
Market Size and Forecast
Autogenic Bones
Market Size and Forecast
Bone Graft Substitutes
Market Size and Forecast
Osteoarticular Diseases
Market Size and Forecast
Other Diseases
Market Size and Forecast

Chapter 8 Market Breakdown by Region

Global Market, by Region
North America
United States
Canada
Europe
Germany
France
United Kingdom
Italy
Russia
Spain
Rest of Europe
Asia-Pacific
China
Japan
Australia
India
Rest of Asia-Pacific
Rest of the World
Market Size and Forecast

Chapter 9 Regulatory Aspects

New and Accelerated Approvals of Regenerative Medicine for Bones and Joint Applications

Chapter 10 Patent Review/New Developments

Patent Analysis, by Year

Chapter 11 Competitive Landscape

Mergers, Acquisitions, and Agreements
Product Launches
Manufacturers of Regenerative Medicine for Bones and Joint Applications and Their Market Share Analysis

Chapter 12 Company Profiles

Anika Therapeutics Inc.
Arthrex Inc.
Baxter International Inc.
Bioventus
Conmed Corp.
Depuy Synthes Products Inc. (Part of Johnson & Johnson)
Medtronic plc
Royal Biologics
Seikagaku Corp.
Smith & Nephew plc
Stryker Corp.
Zimmer Biomet Holdings Inc.

Chapter 13 Appendix: List of Acronyms

List of Tables

Summary Table B: Global Market for Regenerative Medicine in Bone and Joint Applications, by Region, Through 2028
Summary Table A: Global Market for Regenerative Medicine in Bone and Joint Applications, by Technology, Through 2028
Table A: Newly Added Chapters
Table 1: List of Developed Organoids from Various Body Organs
Table 2: Cumulative Number of Hip and Knee Procedures Performed, 2012-2021
Table 3: Global Market for Regenerative Medicine in Bone and Joint Applications, by Technology, Through 2028
Table 4: Biomaterial-Assisted Gene Therapy in Musculoskeletal Research
Table 5: Global Market for Biomaterials in Bone and Joint Applications, by Region, Through 2028
Table 6: Biomaterials Utilized for Specific Target Tissues and Cell Types
Table 7: Global Market for Tissue Engineering in Bone and Joint Applications, by Region, Through 2028
Table 8: Global Market for Stem Cell Therapy in Bone and Joint Applications, by Region, Through 2028
Table 9: Global Market for Regenerative Medicine in Bone and Joint Applications, by Application Type, Through 2028
Table 10: Global Market for Regenerative Medicine in Allogeneic Bones Grafting Applications, by Region, Through 2028
Table 11: Global Market for Regenerative Medicine in Autogenic Bones Grafting Applications, by Region, Through 2028
Table 12: Global Market for Regenerative Medicine in Bone Graft Substitutes Applications, by Region, Through 2028
Table 13: Global Market for Regenerative Medicine in Osteoarticular Disease Applications, by Region, Through 2028
Table 14: Global Market for Regenerative Medicine in Other Diseases Applications, by Region, Through 2028
Table 15: Global Market for Regenerative Medicine in Bone and Joint Applications, by Region, Through 2028
Table 16: North American Market for Regenerative Medicine in Bone and Joint Applications, by Technology, Through 2028
Table 17: North American Market for Regenerative Medicine in Bone and Joint Applications, by Country, Through 2028
Table 18: European Market for Regenerative Medicine in Bone and Joint Applications, by Technology, Through 2028
Table 19: European Market for Regenerative Medicine in Bone and Joint Applications, by Country, Through 2028
Table 20: Asia-Pacific Market for Regenerative Medicine in Bone and Joint Applications, by Technology, Through 2028
Table 21: Asia-Pacific Market for Regenerative Medicine in Bone and Joint Applications, by Country, Through 2028
Table 22: RoW Market for Regenerative Medicine in Bone and Joint Applications, by Technology, Through 2028
Table 23: New and Accelerated Approvals of Regenerative Medicine for Bones and Joint Applications, 2018-2023
Table 24: Patents Registered/Approved on Regenerative Medicine in Bone and Joint Applications, by Assignee Country, 2020-March 2023
Table 25: Patents Granted on Regenerative Medicine in Bone and Joint Applications, by Year, 2020-March 2023
Table 26: Major Patents on Regenerative Medicine in Bone and Joint Applications, 2022-March 2023
Table 27: Recent Mergers, Acquisitions, and Agreements in the Global Regenerative Medicine Market, 2018-2023
Table 28: Recently Launched Products, Global Regenerative Medicine Market, 2018-2023
Table 29: Anika Therapeutics: R&D Expenditures, 2020-2022
Table 30: Anika Therapeutics: Products Offered
Table 31: Anika Therapeutics: Recent Developments, 2019-2023
Table 32: Arthrex Inc.: Products Offered
Table 33: Arthrex Inc.: Recent Developments, 2020-2023
Table 34: Boxer International: R&D Expenditures, 2020-2022
Table 35: Baxter International: Products Offered
Table 36: Baxter International: Recent Developments, 2020-2023
Table 37: Bioventus: R&D Expenditures, 2020-2022
Table 38: Bioventus: Products Offered
Table 39: Bioventus: Recent Developments, 2019-2022
Table 40: CONMED Corp.: R&D Expenditures, 2020-2022
Table 41: CONMED Corp.: Products Offered
Table 42: CONMED Corp.: Recent Developments, 2022
Table 43: Johnson & Johnson (DePuy Synthes Companies, MedTech): R&D Expenditures, 2020-2022
Table 44: Johnson & Johnson (DePuy Synthes Companies): Products Offered
Table 45: Johnson & Johnson (DePuy Synthes Companies): Recent Developments, 2017-2022
Table 46: Medtronic plc: R&D Expenditures, 2020-2022
Table 47: Medtronic plc: Products Offered
Table 48: Medtronic plc: Recent Developments, 2018-2019
Table 49: Royal Biologics: Products Offered
Table 50: Royal Biologics: Recent Developments, 2020-2022
Table 51: Seikagaku Corp.: R&D Expenditures, 2020-2022
Table 52: Seikagaku Corp.: Products Offered
Table 53: Seikagaku Corp.: Recent Developments, 2019-2021
Table 54: Smith & Nephew plc: R&D Expenditures, 2020-2022
Table 55: Smith & Nephew plc: Products Offered
Table 56: Smith & Nephew plc: Recent Developments, 2019-2022
Table 57: Stryker Corp.: R&D Expenditures, 2020-2022
Table 58: Stryker Corp.: Products Offered
Table 59: Stryker Corp.: Recent Developments, 2020-2022
Table 60: Zimmer Biomet Holdings: R&D Expenditures, 2020-2022
Table 61: Zimmer Biomet Holdings: Products Offered
Table 62: Zimmer Biomet Holdings: Recent Developments, 2022-2023
Table 63: Acronyms Used in This Report

List of Figures

Summary Figure A: Global Market Shares of Regenerative Medicine in Bone and Joint Applications, by Technology, 2022
Summary Figure B: Global Market for Regenerative Medicine in Bone and Joint Applications, by Region, 2020-2028
Figure 1: Emerging Technologies in Regenerative Medicines for Bones and Joint Applications
Figure 2: Shares of Platelet-Rich Plasma (PRP) Trials, by Segment, Feb. 2022-Feb. 2023
Figure 3: Shares of the Global Health Expenditure Database, by Select Country, 2022
Figure 4: Global Aging (65 and Over) Population, by Region, 2019 and 2050
Figure 5: Global Market for Regenerative Medicine in Bone and Joint Applications, by Technology, 2020-2028
Figure 6: Global Market Shares of Regenerative Medicine in Bone and Joint Applications, by Technology, 2022
Figure 7: Global Market for Regenerative Medicine for Biomaterials in Bone and Joint Applications, 2020-2028
Figure 8: Global Market for Biomaterials in Bone and Joint Applications, by Region, 2020-2028
Figure 9: Global Market for Tissue Engineering in Bone and Joint Applications, 2020-2028
Figure 10: Global Market for Tissue Engineering in Bone and Joint Applications, by Region, 2020-2028
Figure 11: Global Market for Stem Cell Therapy in Bone and Joint Applications, 2020-2028
Figure 12: Global Market for Stem Cell Therapy in Bone and Joint Applications, by Region, 2020-2028
Figure 13: Global Market Shares of Regenerative Medicine in Bone and Joint Applications, by Type, 2022
Figure 14: Global Market for Regenerative Medicine in Allogeneic Bones Grafting Applications, 2020-2028
Figure 15: Global Market for Regenerative Medicine in Allogeneic Bones Grafting Applications, by Region, 2020-2028
Figure 16: Global Market for Regenerative Medicine in Autogenic Bones Grafting Applications, 2020-2028
Figure 17: Global Market for Regenerative Medicine in Autogenic Bones Grafting Applications, by Region, 2020-2028
Figure 18: Global Market for Regenerative Medicine in Bone Graft Substitutes Applications, 2020-2028
Figure 19: Global Market for Regenerative Medicine in Bone Graft Substitutes Applications, by Region, 2020-2028
Figure 20: Global Market for Regenerative Medicine in Osteoarticular Disease Applications, 2020-2028
Figure 21: Global Market for Regenerative Medicine in Osteoarticular Disease Applications, by Region, 2020-2028
Figure 22: Global Market for Regenerative Medicine in Other Diseases Applications, 2020-2028
Figure 23: Global Market for Regenerative Medicine in Other Diseases Applications, by Region, 2020-2028
Figure 24: Global Market for Regenerative Medicine in Bone and Joint Applications, by Region, 2020-2028
Figure 25: Global Market Shares of Regenerative Medicine in Bone and Joint Applications, by Region, 2022
Figure 26: North American Market Shares of Regenerative Medicine in Bone and Joint Applications, by Technology, 2022
Figure 27: North American Market Shares of Regenerative Medicine in Bone and Joint Applications, by Country, 2022
Figure 28: U.S. Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 29: Canadian Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 30: European Market Shares of Regenerative Medicine in Bone and Joint Applications, by Technology, 2022
Figure 31: European Market Shares of Regenerative Medicine in Bone and Joint Applications, by Country, 2022
Figure 32: German Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 33: French Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 34: U.K. Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 35: Italian Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 36: Russian Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 37: Spanish Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 38: Rest of European Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 39: Asia-Pacific Market Shares of Regenerative Medicine in Bone and Joint Applications, by Technology, 2022
Figure 40: Asia-Pacific Market Shares of Regenerative Medicine in Bone and Joint Applications, by Country, 2022
Figure 41: Chinese Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 42: Japanese Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 43: Australian Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 44: Indian Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 45: Rest of Asia-Pacific Market for Regenerative Medicine in Bone and Joint Applications, 2020-2028
Figure 46: RoW Market Shares of Regenerative Medicine in Bone and Joint Applications, by Technology, 2022
Figure 47: Shares of Patents Registered/Approved on Regenerative Medicine in Bone and Joint Applications, by Assignee Country, 2020-March 2023
Figure 48: Global Market Shares Regenerative Medicine in Bone and Joint Applications, by Key Players, 2022
Figure 49: Anika Therapeutics: Net Revenue, 2018-2022
Figure 50: Anika Therapeutics: Revenue Share, by Business Segment, 2022
Figure 51: Anika Therapeutics: Revenue Share, by Region/Country, 2022
Figure 52: Baxter International: Net Revenue, 2018-2022
Figure 53: Baxter International: Revenue Share, by Business Segment, 2022
Figure 54: Baxter International: Revenue Share, by Region, 2022
Figure 55: Bioventus: Net Revenue, 2018-2022
Figure 56: Bioventus: Revenue Share, by Business Segment, 2022
Figure 57: Bioventus: Revenue Share, by Region, 2022
Figure 58: CONMED Corp.: Net Revenue, 2018-2022
Figure 59: CONMED Corp.: Revenue Share, by Business Segment, 2022
Figure 60: CONMED Corp.: Revenue Share, by Region, 2022
Figure 61: Johnson & Johnson (DePuy Synthes Companies): Net Revenue, 2018-2022
Figure 62: Johnson & Johnson (DePuy Synthes): Revenue Share, by Business Segment, 2022
Figure 63: Johnson & Johnson (DePuy Synthes Companies): Revenue Share, by Region, 2022
Figure 64: Medtronic plc: Net Revenue, 2018-2022
Figure 65: Medtronic plc: Revenue Share, by Business Segment, 2022
Figure 66: Medtronic plc: Revenue Share, by Region, 2022
Figure 67: Seikagaku Corp.: Net Revenue, 2018-2022
Figure 68: Seikagaku Corp.: Revenue Share, by Business Segment, 2022
Figure 69: Smith & Nephew plc: Net Revenue, 2018-2022
Figure 70: Smith & Nephew plc: Revenue Share, by Business Segment, 2022
Figure 71: Smith & Nephew plc: Revenue Share, by Region, 2022
Figure 72: Stryker Corp.: Net Revenue, 2018-2022
Figure 73: Stryker Corp.: Revenue Share, by Business Segment, 2022
Figure 74: Stryker Corp.: Revenue Share, by Region, 2022
Figure 75: Zimmer Biomet Holdings: Net Revenue, 2018-2022
Figure 76: Zimmer Biomet Holdings: Revenue Share, by Business Segment, 2022
Figure 77: Zimmer Biomet Holdings: Revenue Share, by Region, 2022

Executive Summary

Regenerative medicine is an emerging technology that is set to revolutionize healthcare. Regenerative medicine aims to develop processes and methods to regrow, regenerate or repair diseased or damaged cells, tissues, or organs.

The rapid growth rate of the tissue engineering segment is attributed to the growing adoption of products designed and developed for treating tissues such as bone, skeletal muscle, cartilage, blood vessel, nerve tissue, skin, and for complete organs. According to the American Academy of Orthopedic Surgeons (Annual Report 2022), hip and knee arthroplasty procedures continue to increase. American Joint Replacement Registry (AJRR) has analyzed the utilization of technology for surgical assistance in primary total hip and knee arthroplasty for the first time. Approximately 2,550,232 primary and revision hip and knee arthroplasty procedures were performed between 2012 and 2021. The market for regenerative medicine for bone and joint applications is expected to display substantial growth during the forecast period, supported by an increasingly aging population worldwide, the growing occurrence of arthritic conditions such as osteoporosis and osteoarthritis, and an increasing number of orthopedic surgeries. According to WHO, osteoporosis affects approximately 6.3% of men over the age of 50 and 21.2% of women over the same age range globally. According to International Osteoporosis Foundation, by 2050, the worldwide incidence of hip fracture in men is projected to increase by 310% and 240% in women, compared to 1990.

The market has been established in North America and Europe, which currently are the leaders in revenue sharing. However, the growth opportunities are better in emerging economies, especially Brazil, Russia, India, and China (BRIC) nations, due to an increased level of awareness as well as an increase in per capita income. Moreover, the increased focus of manufacturers toward emerging economies and innovative formulas to sell in emerging markets are further boosting the market’s growth.

The major players in the market are Smith & Nephew, DePuy Synthes, Medtronic plc, Stryker Corp., Bioventus, Zimmer Biomet, Anika Therapeutics, Baxter, and CONMED Corp.

The global market for regenerative medicine for bone and joint applications was valued at $9.6 billion in 2022. By technology, this market is segmented into biomaterials, stem cell therapy, and tissue engineering. The tissue engineering segment recorded $2.4 billion in revenue in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 13.3% during the forecast period

Companies Mentioned

Anika Therapeutics Inc.
Arthrex Inc.
Baxter International Inc.
Bioventus
Conmed Corp.
Depuy Synthes Products Inc. (Part of Johnson & Johnson)
Medtronic plc
Royal Biologics
Seikagaku Corp.
Smith & Nephew plc
Stryker Corp.
Zimmer Biomet Holdings Inc.

Table Information

Report Attribute	Details
No. of Pages	147
Published	May 2023
Forecast Period	2023 - 2028
Estimated Market Value ( USD ) in 2023	$ 10.7 Billion
Forecasted Market Value ( USD ) by 2028	$ 18.9 Billion
Compound Annual Growth Rate	12.1%
Regions Covered	Global
No. of Companies Mentioned	12

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Report Includes

Table of Contents

Executive Summary

Companies Mentioned

Table Information

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