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Hypersomnia - Pipeline Insight, 2024

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    Clinical Trials

  • 60 Pages
  • June 2024
  • Region: Global
  • DelveInsight
  • ID: 4037530
This “Hypersomnia - Pipeline Insight, 2024” report provides comprehensive insights about 9+ companies and 10+ pipeline drugs in Hypersomnia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Hypersomnia: Understanding

Hypersomnia: Overview

Hypersomnia is a state of excessive sleepiness which can result in decreased functioning and affect performance adversely. Hypersomnolence is defined as an inability to stay awake and alert during major waking episodes, resulting in periods of irrepressible need for sleep or unintended lapses into drowsiness or sleep. Lapses into sleep without prodromal symptoms of increasing sleepiness are called sleep attacks. Excessive daytime sleepiness (EDS) is one of the big public health problem. Patients with EDS have decreased workplace productivity, lower quality of life and increased risk of work-related injury.

The causes of hypersomnia can be diverse and include various factors such as sleep disorders like narcolepsy and sleep apnea, insufficient sleep, idiopathic hypersomnia, being overweight, drug or alcohol abuse, head injuries, neurological diseases like multiple sclerosis or Parkinson's disease, certain medications, genetics, and depression. Other potential causes may involve autonomic nervous system dysfunction, tumors, encephalitis, epilepsy, and chronic sleep deprivation, among others.

The exact etiology of idiopathic hypersomnia (IH) remains unclear, but several potential triggers and contributing factors have been identified. Abrupt changes in sleep-wake habits, overexertion, general anesthesia, viral illnesses, and mild head trauma have been associated with the development of IH symptoms. Rare genetic predispositions may also play a role, with subgroups of IH linked to reduced signaling of the neuropeptide orexin due to variants in the prepro-orexin gene.

Excessive daytime sleepiness and associated symptoms (such as automatic behaviors) can lead to danger to self and others, including an increased risk of motor vehicle accidents. Due to the potential for diversion as a "date rape" drug, access to oxybate is regulated in the United States and is controlled under Schedule III.

Non-pharmacologic treatments for hypersomnia focus on improving sleep quality and quantity. Good sleep hygiene practices, such as avoiding stimulants before bed, maintaining a regular sleep schedule, and keeping the sleeping environment comfortable, can help enhance night time sleep. Scheduled daytime naps of 15-20 minutes have been shown to reduce daytime sleepiness without negatively impacting nighttime sleep quality, though their effectiveness has been more extensively studied in narcolepsy compared to other hypersomnia. Regular physical activity can also be beneficial for improving sleep.

"Hypersomnia - Pipeline Insight, 2024" report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Hypersomnia pipeline landscape is provided which includes the disease overview and Hypersomnia treatment guidelines. The assessment part of the report embraces, in depth Hypersomnia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Hypersomnia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Hypersomnia R&D. The therapies under development are focused on novel approaches to treat/improve Hypersomnia.

Hypersomnia Emerging Drugs Chapters

This segment of the Hypersomnia report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II/III, II, I, preclinical and discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Hypersomnia Emerging Drugs

KP1077 - Zevra Therapeutics

Serdexmethylphenidate (SDX) is the sole active pharmaceutical ingredient (API) in KP1077, KemPharm’s lead clinical candidate being developed as a treatment for IH and narcolepsy. The drug is currently being evaluated under Phase II clinical trial for the treatment of patients with hypersomnia.

ALKS 2680: Alkermes

ALKS 2680 is an investigational, oral orexin 2 receptor agonist in development as a once-daily treatment for narcolepsy. The drug is currently being evaluated under Phase I clinical trial for the treatment of Hypersomnia.

Hypersomnia: Therapeutic Assessment

This segment of the report provides insights about the different Hypersomnia drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Hypersomnia

There are approx. 9+ key companies which are developing the therapies for Hypersomnia. The companies which have their Hypersomnia drug candidates in the most advanced stage, i.e. Phase II include, Zevra Therapeutics.

Phases

This report covers around 10+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates

Route of Administration

Hypersomnia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Intravenous
  • Subcutaneous
  • Oral
  • Intramuscular
  • Molecule Type

Products have been categorized under various Molecule types such as

  • Monoclonal antibody
  • Small molecule
  • Peptide
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Hypersomnia: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Hypersomnia therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Hypersomnia drugs.

Hypersomnia Report Insights

  • Hypersomnia Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Hypersomnia Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Hypersomnia drugs?
  • How many Hypersomnia drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Hypersomnia?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Hypersomnia therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Hypersomnia and their status?
  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • Axsome Therapeutics
  • Alkermes
  • Zevra Therapeutics
  • Takeda
  • Aexon Labs

Key Products

  • Reboxetine
  • ALKS 2680
  • Serdexmethylphenidate
  • TAK-861
  • AEX-19


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Table of Contents

IntroductionExecutive Summary
Hypersomnia: Overview
  • Causes
  • Etiology
  • Signs and Symptoms
  • Disease Management/Treatment
Pipeline Therapeutics
  • Comparative Analysis
Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type
Hypersomnia- Analytical Perspective
Late Stage Products (Phase III)
  • Comparative Analysis
Drug Name: Company Name
  • Product Description
  • Research and Development
  • Product Development Activities
Mid Stage Products (Phase II)
  • Comparative Analysis
KP1077 - Zevra Therapeutics
  • Product Description
  • Research and Development
  • Product Development Activities
Early Stage Products (Phase I)
  • Comparative Analysis
ALKS 2680: Alkermes
  • Product Description
  • Research and Development
  • Product Development Activities
Preclinical and Discovery Stage Products
  • Comparative Analysis
Drug name: Company name
  • Product Description
  • Research and Development
  • Product Development Activities
Inactive Products
  • Comparative Analysis
Hypersomnia Key CompaniesHypersomnia Key ProductsHypersomnia- Unmet NeedsHypersomnia- Market Drivers and BarriersHypersomnia- Future Perspectives and ConclusionHypersomnia Analyst ViewsHypersomnia Key CompaniesAppendix
List of Tables
Table 1 Total Products for Hypersomnia
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
List of Figures
Figure 1 Total Products for Hypersomnia
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Axsome Therapeutics
  • Alkermes
  • Zevra Therapeutics
  • Takeda
  • Aexon Labs