Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft.
The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour.
This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise.
The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.
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Table of Contents
Section 1: Functional anatomy of the serotonergic system 1.1 Evolution of serotonin: sunlight to suicide by Efrain C. Azmitia; 1.2. Genetic organisation of the serotonergic system by Ursula M. D'Souza and Ian W. Craig; 1.3. The neuronatomy of the serotonergic system by Jean-Pierre Hornung; 1.4. Ultrastructure of the serotonin innervation in mammalian central nervous system by Laurent Descarries Mustapha Riad and Martin Parent; 1.5. Classification and signaling characteristics of 5-HT receptors by Joël Bockaert, Sylvie Claeysen, Aline Dumuis and Philippe Marin; 1.6. Distribution of 5-HT receptors in the central nervous system by Guadalupe Mengod, Roser Cortés, M. Teresa Vilaró and Daniel Hoyer; 1.7. Measuring serotonin activity in vivo in the brains of animals and humans by Charles A Marsden
Section 2: The neurophysiology of serotonin 2.1 Activity of brain serotonergic neurons in relation to physiology and behavior by Barry L. Jacobs and Casimir A. Fornal; 2.2 Electrophysiology of serotonin receptors by Gerard J. Marek; 2.3 Tryptophane hydroxylase and serotonin synthesis regulation by Hiroyuki Hasegawa and Kazuhiro Nakamura; 2.4 The degradation of serotonin: role of MAO by Marco Bortolato, Kevin Chen and Jean C Shih; 2.5 Cellular effects of serotonin in the CNS by Rodrigo Andrade and Sheryl G. Beck; 2.6 Serotonergic feedback control by Trevor Sharp; 2.7 Tryptophan depletion and serotonin release a critical reappraisal by Matthijs G.P. Feenstra and Geoffrey van der Plasse; 2.8 Serotonin interaction with other transmitter systems by Albert Adell, Analía Bortolozzi, Llorenç Díaz-Mataix, Noemí Santana, Pau Celada, and Francesc Artigas; 2.9 Serotonergic regulation of rhythmical activity of the brain, concentrating on the hippocampus by Robert P. Vertes; 2.10 5-HT neurons and central CO2 chemoreception by Carolin I. Dohle and George B. Richerson
Section 3: Serotonin and behavioural control 3.1 Serotonin and development by Patricia M. Whitaker-Azmitia; 3.2 Serotonin and basal sensory: motor control by Robert J. Carey; 3.3 Role of the serotonergic system in appetite and ingestion control by Michelle D. Lee and Peter G. Clifton; 3.4 Serotonin and sexual behavior by Lynda Uphouse and Jutatip Guptarak; 3.5 Serotonin in mood and emotion by Julie G. Hensler; 3.6 Serotonin and the neurobiology of anxious states by Christopher A. Lowry and Matthew W. Hale; 3.7 Role of Serotonin in Brain Reward and Regulation of Alcohol Drinking Behavior by W. J. McBride; 3.8 Role of central serotonin in impulsivity and compulsivity: Comparative studies in experimental animals and humans by TW Robbins & MJ Crockett; 3.9 Experimental studies on the role(s) of serotonin in learning and memory functions by Jean-Christophe Cassel; 3.10 Social behavior and serotonin by Elif Aysimi Duman and Turhan Canli; 3.11 Serotonin in pain and pain control by Claudia Sommer
Section 4: Serotonin in disease conditions 4.1 The Impact of Stress on Serotonergic Neurotransmission by Astrid C.E. Linthorst and Johannes M.H.M. Reul; 4.2 Role for serotonin in depression by Gregory V. Carr and Irwin Lucki; 4.3 The role of serotonin in drug addiction by Christian P. Müller, Martin E. Pum, Gunter Schumann and Joseph P. Huston; 4.4 The serotonergic system in obsessive compulsive disorders by Addy van Dijk, Andre Klompmakers, and Damiaan Denys; 4.5 The role of serotonin in attention-deficit hyperactivity disorder (ADHD) by Robert D. Oades; 4.6 Serotonin and schizophrenia by Boris B. Quednow, Mark A. Geyer, and Adam L. Halberstadt; 4.7 Serotonin and serotonin receptors in hallucinogen action by Adam L. Halberstadt and David E. Nichols; 4.8 The role of serotonin in cortical development: implications for Autism Spectrum Disorder [ASD] by Christine F. Hohmann and Mary E. Blue; 4.9 Serotonin in panic and anxiety disorders by Francisco Silveira Guimarães, Hélio Zangrossi Jr., Cristina Marta Del Ben and Frederico Guilherme Graeff; 4.10 Serotonin and agression by Isabel M. Quadros, Aki Takahashi and Klaus A. Miczek; 4.11 Altered serotonin function in anorexia and bulimia nervosa by Vikas Duvvuri, Ursula F Bailer and Walter H Kaye; 4.12 Genetic, epigenetic, and environmental factors in serotonin associated disease conditions by Eva Friedel and Andreas Heinz; 4.13 The Behavioral Genetics of Serotonin: Relevance to Anxiety and Depression by Olivia F. O'Leary and John F. Cryan; 4.14 Functional pharmacogenetics of serotonin receptors in psychiatric drug action by Olga O. Yevtushenko, Gavin P. Reynolds
