Table of Contents
List of contributors, x
Preface, xxv
Part 1: Symptoms, Syndromes, and Scenarios Discomfort above the diaphragm
1 Heartburn and noncardiac chest pain, 3
Tiberiu Hershcovici and Ronnie Fass
2 Dysphagia and odynophagia, 11
Stacey R. Zavala and Philip O. Katz
Discomfort below the diaphragm
3 Chronic or recurrent abdominal pain, 16
Ayman Koteish and Anthony N. Kalloo
4 Dyspepsia: ulcer and non-ulcer/bloating and early satiety/belching and rumination, 22
Alexander C. Ford and Paul Moayyedi
5 Nausea and vomiting, 26
Jan Tack
Disorders of defecation
6 Diarrhea, 32
Matthew R. Banks and Michael J. G. Farthing
7 Fecal incontinence, 43
Ashok Attaluri and Satish S. C. Rao
8 Rectal bleeding, 47
Benjamin Krevsky
9 Anorectal pain and pruritusani, 51
Steven D. Wexner and Giovanna M. da Silva
Generalized ill health
10 Functional gastrointestinal disease, 54
C. J. Hawkey, Jaime Bosch, Joel E. Richter, Guadalupe Garcia-Tsao, and Francis K. L. Chan
11 Anorexia nervosa and bulimia nervosa, 61
Tomas J. Silber
12 Weight loss, 68
Arvey I. Rogers, Hendrikus S. Vanderveldt and Amar R. Deshpande
13 Gastrointestinal causes of anemia and occult bleeding, 73
Kevin A. Ghassemi, Dennis M. Jensen and Rome Jutabha
28 Benign esophageal strictures and caustic esophageal injury, 194
Timothy T. Nostrant
Esophageal: malignant and pre-malignant
29 Barrett’s esophagus, 197
Neil Gupta and Prateek Sharma
30 Esophageal cancer, 204
Tamas A. Gonda and Charles J. Lightdale
Upper gastrointestinal infections
31 Infections of the esophagus and stomach, 214
George B. McDonald
Gastroduodenal: benign
32 Peptic ulcer, 219
C. J. Hawkey and John C. Atherton
33 Gastritis, 234
Richard H. Lash and Robert M. Genta
Gastroduodenal: malignant and pre-malignant
34 Adenocarcinoma (gastric cancer and miscellaneous malignancy), 248
Dai-ming Fan and Kai-chun Wu
35 Gastric lymphoma, 254
Andrea Grin and Runjan Chetty
Motility disorders
36 Esophageal motility disorders, 258
Peter J. Kahrilas
37 Gastric motility disorders, 265
Jan Tack
Section 2: Disorders of the Small and Large Bowel Food, nutrition and malabsorption
38 Food allergy and intolerance, 272
Stephan C. Bischoff and Katrin Feuser
39 Maldigestion and malabsorption, 279
Arvey I. Rogers and Ryan D. Madanick
40 Celiac disease, 288
Daniel A. Leffler, Andrés Cárdenas and Ciarán P. Kelly
41 Short bowel syndrome, 299
Christian S. Jackson and Alan L. Buchman
42 Small intestinal bacterial overgrowth, 305
Ahmed Abu Shanab, Rodrigo M. Quera and Eamonn M. M. Quigley
43 Bile acid malabsorption, 311
Linda Wedlake and Jervoise Andreyev
44 Protein-losing disorders of the gastrointestinal tract, 318
Simon Murch
Intestinal infections and infestations
45 Infective diarrhea, 324
Michael J. G. Farthing and Anna Casburn-Jones
46 Travelers’ diarrhea, 338
Andrew W. DuPont and Herbert L. DuPont
47 Abdominal tuberculosis, 342
Bhupinder Anand
48 Parasites, 349
John Croese
Inflammatory bowel disease
49 Ulcerative colitis, 355
Fergus Shanahan
50 Crohn’s disease, 372
Séverine Vermeire, Gert Van Assche and Paul Rutgeerts
51 Indeterminate colitis, 394
Stephan R. Targan and C. J. Hawkey
52 Microscopic colitis, 399
Frank Hoentjen, Chris Mulder and Gerd Bouma
53 Eosinophilic disorders of the gastrointestinal tract, 406
Jon A. Vanderhoof and Rosemary J. Young
54 Pseudomembranous colitis, 412
Tanya M. Monaghan and Yashwant R. Mahida
55 Ischemia/ischemic colitis, 417
Aliya G. Hasan and Joel S. Levine
Malignant tumors
56 Small bowel tumours, 421
Matthew P. Spinn and Sushovan Guha
57 Biology and genetics of colorectal cancer and polyps and polyposis, 428
Ajay Goel and Christian Arnold
58 Colorectal cancer: screening and surveillance, 438
Austin G. Acheson and John H. Scholefield
59 Colorectal cancer: a multidisciplinary approach, 444
Rachel S. Midgley, Haitham M. Al-Salama, A. Merrie, N. Mortensen, and David J. Kerr
Motility disorders
60 Obstruction and volvulus, 455
Rakesh Bhardwaj and Michael C. Parker
61 Constipation and constipation syndromes, 462
Adil E. Bharucha and Madhusudan Grover
62 Irritable bowel syndrome, 472
Robin Spiller
63 Diverticular disease of the colon, 482
Anish A. Sheth and Martin H. Floch
64 Megacolon and pseudo-obstruction, 488
Eamonn M. M. Quigley
Other disorders of the small and large bowel
65 Splanchnic vascular disorders, 493
J. Hajo van Bockel, Robert H. Geelkerken and Jeroen J. Kolkman
66 Drug-induced damage to the small and large intestine, 498
Ingvar Bjarnason, Zeino Zeino and Guy Sisson
67 Acute appendicitis, 505
John Simpson and David J. Humes
Anorectal diseases
68 Anorectal diseases, 511
Steven D. Wexner and Giovanna M. da Silva
Section 3: Diseases of the Pancreas and Biliary Tract Pancreas
69 Acute pancreatitis, 518
Georgios Papachristou, Vijay Singh and David C. Whitcomb
70 Chronic pancreatitis, 525
Pascal O. Berberat, Güralp O. Ceyhan, Zilvinas Dambrauskas, Markus W. Büchler, and Helmut Friess
71 Pancreatic exocrine tumors, 533
Paula Ghaneh and John P. Neoptolemos
72 Cysts and pseudocysts of the pancreas, 546
Brian G. Turner and William R. Brugge
73 Development and miscellaneous abnormalities, 552
Erica Makin and Mark Davenport
Biliary tract
74 Cholelithiasis, choledocholithiasis, and cholecystitis, 557
Franz Ludwig Dumoulin and Tilman Sauerbruch
75 Sphincter of Oddi dysfunction, 567
Dana C. Moffatt, Stuart Sherman and Evan L. Fogel
76 Primary sclerosing cholangitis, 573
Sombat Treeprasertsuk and Keith D. Lindor
77 Cholangiocarcinoma, 580
Konstantinos N. Lazaridis and Gregory J. Gores
Malformations
78 Congenital abnormalities of the biliary tract, 586
Daniel Dhumeaux, Elie Serge Zafrani, Daniel Cherqui, and Alain Luciani
Section 4: Liver Disease
Infections
79 Acute viral hepatitis, 593
Amer Skopic and Maria H. Sjogren
80 Chronic hepatitis B, 603
Tarik Asselah, Olivier Lada, Rami Moucari, and Patrick Marcellin
81 Chronic viral hepatitis C, 610
Xavier Forns and Jose M. Sánchez-Tapias
82 Chronic viral hepatitis D, 618
Patrizia Farci and Maria Eliana Lai
83 Liver worms, 623
Donald P. McManus
84 Liver protozoa, 630
David Kershenobich, Guillermo Robles-Diaz and Juan Miguel Abdo Francis
85 Bacterial and fungal infections of the liver, 633
Simon Rushbrook and Alexander Gimson
86 Primary biliary cirrhosis, 638
Raoul Poupon
Autoimmune and related disorders
87 Autoimmune hepatitis and overlap syndromes, 642
Heike Bantel, Kinan Rifai and Michael P. Manns
Genetic, metabolic and iatrogenic liver diseases
88 Alcoholic liver diseases, 649
Jennifer T. Wells and Michael R. Lucey
89 Nonalcoholic fatty liver disease, 658
Arthur J. McCullough and Srinivasan Dasarathy
90 Hemochromatosis, 675
Antonello Pietrangelo
91 Alpha-1-antitrypsin deficiency, 683
Feras T. Alissa and David H. Perlmutter
92 Wilson disease, 689
Peter Ferenci
93 Drug prescription in liver disease, 695
Guido Stirnimann and Jürg Reichen
94 Genetic and metabolic liver diseases in childhood, 700
Giorgina Mieli-Vergani and Richard Thompson
95 Disturbances of bilirubin metabolism, 706
Cristina Bellarosa and Claudio Tiribelli
Cirrhosis of the liver and its complications
96 Polycystic liver diseases, 713
Luca Fabris, Catherine McCrann and Mario Strazzabosco
97 Cirrhosis of the liver, 719
Gennaro D’Amico and Giuseppe Malizia
98 Portal hypertension, 728
Juan Carlos García-Pagán, Roberto J. Groszmann and Jaime Bosch
99 Ascites and hepatorenal syndrome, 737
Andrés Cárdenas and Pere Ginès
100 Spontaneous bacterial peritonitis, 745
Guadalupe Garcia-Tsao
101 Hepatopulmonary syndrome and portopulmonary hypertension, 751
Rajan Kochar and Michael B. Fallon
102 Hepatic encephalopathy, 757
Thomas A. Brown and Kevin D. Mullen
103 Acute liver failure, 766
John G. O’Grady and Julia Wendon
Other liver diseases
104 Tumors of the liver, 773
Alejandro Forner, Carlos Rodríguez de Lope, María Reig, and Jordi Bruix
105 Vascular disorders of the liver, 786
Dominique-Charles Valla
106 Granulomas of the liver, 793
Miquel Bruguera Cortada and Rosa Miquel Morera
107 Liver diseases and pregnancy, 799
J. Eileen Hay
Liver transplantation
108 Liver transplantation: indications and selection of candidates and immediate complications, 805
Patrick S. Kamath and John J. Poterucha
109 Long-term management of recurrent primary liver disease, 813
Kiran Bambha and Norah A. Terrault
Section 5: Diseases of Multiple Organ Systems
110 Collagen vascular and vasculitic disorders, 831
Ulf Müller-Ladner and Jürgen Schölmerich
111 Systemic disease and the gastrointestinal tract, 839
Paul J. Fortun
112 Pancreatic endocrine tumors, 844
Robert T. Jensen
113 The carcinoid syndrome, 858
Eva Tiensuu Janson and Kjell Öberg
114 AIDS and the gut, 865
C. Mel Wilcox
115 Graft-versus-host disease, 873
George B. McDonald
116 Radiation and other physicochemical injury, 879
Keith Leiper and Andrew R. Moore
117 Systemic amyloidosis, 886
Prayman T. Sattianayagam and Philip N. Hawkins
118 Foreign bodies, 893
Lisa Swize and Patrick R. Pfau
119 Porphyria, 898
Jean-Charles Deybach and Hervé Puy
120 The hereditary recurrent fevers, 908
Elizabeth Drewe
Section 6: Abdominal Wall and Cavity
121 Abscesses and other intra-abdominal diseases, 913
Juliane Bingener, Melanie L. Richards and Kenneth R. Sirinek
122 Hernia, 919
Cindy Matsen and Leigh Neumayer
Part 3: Primer of Diagnostic Methods Endoscopic imaging
123 Upper gastrointestinal endoscopy and mucosal biopsy, 927
Jayan Mannath and Krish Ragunath
124 Lower gastrointestinal endoscopy and biopsy, 936
Jerome D. Waye
125 Endoscopic ultrasonography, 943
V. Raman Muthusamy and Kenneth J. Chang
126 Diagnostic and interventional endoscopic retrograde cholangiopancreatography, 951
George J. M. Webster and Stephen P. Pereira
127 Enteroscopy (double-balloon), 961
Tomonori Yano and Hironori Yamamoto
128 Capsule endoscopy, 969
Christina A. Tennyson and Blair S. Lewis
129 Confocal endomicroscopy, 975
Martin Goetz and Ralf Kiesslich
130 Self-propelled colonoscopy, 983
Menachem Moshkowitz and Nadir Arber Percutaneous imaging
131 Percutaneous ultrasound, 989
Winnie C. W. Chu and Vivian Y. F. Leung
132 Barium radiology, 1000
Simon A. Jackson and Bruce M. Fox
133 Computed tomography, 1006
Karin Herrmann and Pablo R. Ros
134 Magnetic resonance imaging, 1014
Luca Marciani, Robin C. Spiller, Penny A. Gowland, and Peter D. Thurley
135 Magnetic resonance cholangiopancreatography, 1021
V. Anik Sahni and Koenraad J. Mortele
136 Virtual colonoscopy, 1027
Abraham H. Dachman, Ila Sethi and Philippe Lefere
137 Positron emission tomography, 1035
Sebastian Obrzut and Michael S. Kipper
138 Non-invasive liver assessment, 1042
M. Beaugrand
Functional testing
139 Gastrointestinal motility testing, 1046
Priyanka Sachdeva and Henry P. Parkman
140 Measurement of portal pressure, 1054
Annalisa Berzigotti and Juan G. Abraldes
Tissue testing
141 Liver biopsy, 1060
Cristina Ripoll and Rafael Bañares
142 Optimal tissue sampling: the pathologist’s perspective, 1066
Richard H. Lash, Shari L. Taylor and Robert M. Genta
Part 4: Primer of Treatments
Medical treatments
143 Drug prescription in liver disease, 1077
Guido Stirnimann and Jürg Reichen
144 Nutritional assessment and support, 1082
T. E. Bowling
Therapeutic endoscopy
145 Variceal ligation, sclerotherapy, and other hemostatic techniques for varices and other lesions, 1092
Louis-Michel Wong Kee Song
146 Non-variceal upper gastrointestinal bleeding, 1103
Majid Almadi and Alan Barkun
147 Photodynamic therapy in the gastrointestinal tract, 1111
Masoud Panjehpour and Bergein F. Overholt
148 Percutaneous endoscopic gastrostomy and jejunostomy, 1120
Jeffrey L. Ponsky and Benjamin K. Poulose
149 Endoscopic techniques of removing early gastrointestinal neoplams, 1126
Haruhiro Inoue and Hitomi Minami
150 Dilation and stenting of the gastrointestinal tract, 1134
Lucio Petruzziello, Michele Marchese and Guido Costamagna
151 NOTES, 1142
D. Nageshwar Reddy, G. V. Rao and Magnus J. Mansard
Percutaneous therapy
152 The transjugular intrahepatic portosystemic shunt (TIPS), 1147
Christophe Bureau, Philippe Otal and Jean-Pierre Vinel
153 Interventional radiology, 1153
Simon Chun-Ho Yu and Joyce Wai Yi Hui
154 Paracentesis, 1158
Andrea De Gottardi, Chong-Meng Yeo and Guadalupe Garcia-Tsao
A synopsis of surgical operations
155 Liver operations, 1163
J. Michael Henderson and Michael D. Johnson
156 Gastrointestinal operations, 1174
Robert J. C. Steele
157 Minimally invasive surgery, 1182
Todd A. Ponsky, Arjun Khosla and Jeffrey L. Ponsky
Index, 1191
