There is a general need amongst healthcare professionals for practical advice on the management of patients with bleeding disorders. This book is an essential resource for all those working in the fields of coagulation, hemostasis and thrombosis. It covers the major cases one might encounter in diagnosing, managing and treating hemophilia and hemostasis. It provides a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders.
The book is divided into major chapter sections depending on the type of bleeding disorder it fits into. Each chapter includes a brief overview of the disorder covering: history of the disorder; molecular basis of the disorder; class presentation; genetics; current laboratory tests and monitoring. Cases associated with each disorder are presented alongside practical questions and answers from a wide range of contributors. As practice can vary from center to center, controversial areas are clearly marked and discussed throughout.
New to this edition: coverage of the newer techniques; newer treatment modalities; new oral anticoagulants; update on hemophilia management; more on ITP and greater coverage of new cases as suggested by reviewers.
Table of Contents
List of ContributorsForeword
SECTION 1: HAEMOPHILIA A AND HAEMOPHILIA B
General Overview
The hemophilic ankle: an update
The haemophilic knee: An update
Haemophilia with Inhibitors
Inhibitor patient requiring high dose therapy with rVIIa as well as sequential therapy with FEIBA.
Prophylactic therapy in a patient with a high titer inhibitor
Immune Tolerance Induction
Monitoring during ITI
FIX inhibitors
Severe Hemophilia B with high response inhibitor and anaphylactic reaction to factor IX
Inhibitor patient and dental surgery
Haemophilic treatment for procedures
DVT prophylaxis in patients with hemophilia A undergoing orthopedic surgery
Prostate Surgery and Hemophilia
Mild Hemophilia and Intraocular Injections
Endoscopy/colonoscopy and Hemophilia
Dialysis and Hemophilia
Circumcision
PK Studies prior to Orthopedic Surgery
Compartment Syndrome
Successful eradication of factor VIII inhibitor in patient with mild Hemophilia A prior to
hemipelvectomy for extensive hemophilic pseudotumor
Coronary artery disease and hemophilia
Valve Replacement and Hemophilia
Treatment for other conditions
Thyroid biopsy and Hemophilia
Atrial Fibrillation and bleeding disorders
Chronic Upper GI bleeding and hemophilia
Hematuria
Other issues in haemophilia care
Reproductive Options for Hemophilia A Carriers
Mild Hemophilia A with Discrepant FVIII activity levels
Compund Diagnoses
Hemophilia A with tuberous sclerosis and CNS bleed
Familial Risk Assessment for Individuals with Hemophilia A and von Willebrand Disease
Hemophilia A and HHT
SECTION 2: VON WILLEBRAND DISEASE
Management during procedures
Type I VWD Tonsillectomy
VWD and Dental surgery
VWD and GI surgery
VWD and Obstetric/Gynecologic Procedures
Rare forms of Von Willebrand Disease
Type 2A VWD and recurrent GI bleeding
Type 2B VWD and Thoracic Surgery
Von Willebrand disease 2N
SECTION 3: OTHER BLEEDING DISORDERS
Prothrombin deficiency
Factor V deficiency
Factor VII deficiency
FX deficiency
Factor XI deficiency
Factor XIII deficiency
Combined factor V and factor VIII deficiency 1, 2
Glanzmann Thrombaesthenia
Gardner-Diamond syndrome and VWD
Qualitative Platelet Disorder - QPD
SECTION 4: ACQUIRED BLEEDING DISORDERS
Acquired FVIII inhibitor and B cell neoplasm
FVIII inhibitor and lupus inhibitor
Acquired VWD
A woman with bleeding gums
Bleeding after cardiac surgery
Bleeding in a dialysis patient
A woman with anemia and hematuria
Scalp bleeding in an older gentleman
Hyperfibrinolysis
SECTION 5: THROMBOTIC DISORDERS
Heparin induced thrombocytopenia with thrombosis
Heparin Skin Necrosis
Warfarin skin necrosis
Thoracic outlet syndrome 3, 4
Antithrombin Deficiency
May-Thurner syndrome
Thrombosis in a liver transplant patient
Combined thrombophilia
Index
