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Biological Reaction Engineering. Dynamic Modelling Fundamentals with Simulation Examples. 3rd Edition

  • Book

  • 600 Pages
  • June 2021
  • John Wiley and Sons Ltd
  • ID: 2326726
Biological reactions may be mediated by enzymes, and whole microbial, animal or plant cells are at the core of many processes and products in a wide range of industries, such as the food and beverage, health, pharmaceutical, environmental, and chemical industries. Biological engineering has gained in breadth as we have moved from traditional biological processes for chemicals and pharmaceuticals to modern biotech medicine, and to specialty chemicals for food and industrial use. At the same time, much progress has been made in systems biology and metabolic engineering leading to next generation processes for biofuels and chemicals. Biological engineering still represents the heart of the biotech industry, such that the scaling of high productivity processes as well as the increased use of automation is critical.
This practical book presents the modeling of dynamic biological engineering processes in a readily comprehensible manner, using the unique combination of simplified fundamental theory and direct hands–on computer simulation. The mathematics is kept to a minimum, and yet the 60 examples supplied on the web–server illustrate almost every aspect of biological engineering science, with each one described in detail, including the model equations. The programs are written in the modern user–friendly simulation language Berkeley Madonna, which runs on both Windows PC and Apple computers. The results may be viewed simultaneously on multiple–graph windows or by using overlays, and the examples varied to fit any real situation.
The authors? extensive teaching experience is reflected in this well–balanced presentation, which is suitable for teachers, students, biochemists or engineers.

Table of Contents

PART I: Principles of Bioreactor Modelling

MODELLING PRINCIPLES
Fundamentals of Modelling
Formulation and Structuring of the Problem
Formulation of Balance Equations
BASIC BIOREACTOR CONCEPTS
Information for Bioreactor Modelling
Bioreactor Operation
BIOLOGICAL KINETICS
Enzyme Kinetics
Simple Microbial Kinetics
Structured Kinetic Models
BIOREACTOR MODELLING
General Balances for Tank–Type Biological Reactors
Modelling Tubular Plug Flow Bioreactors
MASS TRANSFER
Mass Transfer in Biological Reactors
Interphase Gas–Liquid Mass Transfer
General Oxygen Balances for Gas–Liquid Transfer
DIFFUSION AND BIOLOGICAL REACTION IN IMMOBILIZED BIOCATALYST SYSTEMS
External Mass Transfer
Internal Diffusion and Reaction within Biocatalysts
AUTOMATIC BIOPROCESS CONTROL FUNDAMENTALS
Elements of Feedback Control
Types of Controller Action
Advanced Control Strategies
Controller Tuning
Concepts for Bioprocess Control
BASICS OF CELL FACTORY MODELLING
Modularisation of Cell Modelling (Transport, Enzymatic Reactions, Enzyme Regulation, Expression Control, ...)
Compartmentation and Transport
Combination of Model Elements (Kinetics, Regulation, Induction, Repression, Transport, ...)
Cell Population Modelling

PART II: Modelling, Dynamic Simulation Examples, and the BERKELEY MADONNA Simulation Language

EXAMPLES OF MODEL SET UP
Introductory Examples
SIMULATION EXAMPLES OF BIOLOGICAL REACTION PROCESSES USING BERKELEY MADONNA
Introductory Examples
Batch Reactors
Fed Batch Reactors
Continuous Reactors
Oxygen Uptake Systems
Controlled Reactor
Diffusion Systems
Multi–Organism Models

Authors

Irving J. Dunn Elmar Heinzle John Ingham Jiri E. Prenosil