MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics.
Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.
Table of Contents
Foreword ixSir David Baulcombe
Preface xi
Contributors xiii
1 MICRORNAS: A BRIEF INTRODUCTION 1
Charles H. Lawrie
PART I: MICRORNAS AS PHYSIOLOGICAL REGULATORS 25
2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27
Erika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte
3 MICRORNAS AS REGULATORS OF IMMUNITY 41
Donald T. Gracias and Peter D. Katsikis
4 REGULATION OF SENESCENCE BY MICRORNAS 59
Ioannis Grammatikakis and Myriam Gorospe
5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS IMPLICATED IN AGING 77
Alejandro P. Ugalde, Agnieszka Kwarciak, Xurde M. Caravia, Carlos López-Otín, and Andrew J. Ramsay
6 MICRORNAS AND HEMATOPOIESIS 91
Sukhinder K. Sandhu and Ramiro Garzon
7 MICRORNAS IN PLATELET PRODUCTION AND ACTIVATION 101
Leonard C. Edelstein, Srikanth Nagalla, and Paul F. Bray
PART II: MICRORNAS IN INFECTIOUS DISEASE: HOST–PATHOGEN INTERACTIONS 117
8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS INTERACTIONS 119
Aurélie Fender and Sébastien Pfeffer
9 MICRORNA EXPRESSION IN AVIAN HERPESVIRUSES 137
Yongxiu Yao and Venugopal Nair
10 FUNCTION OF HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153
Natalie L. Reynolds, Jon A. Pavelin, and Finn E. Grey
11 INVOLVEMENT OF SMALL NON-CODING RNA IN HIV-1 INFECTION 165
Guihua Sun, John J. Rossi, and Daniela Castanotto
12 MICRORNA IN MALARIA 183
Panote Prapansilp and Gareth D.H. Turner
PART III: CANCER 199
13 THE MICRORNA DECALOGUE OF CANCER INVOLVEMENT 201
Tanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and George A. Calin
14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223
Eva E. Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and Pedro P. Medina
15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245
Yolanda Sánchez and Maite Huarte
16 REGULATION OF HYPOXIA RESPONSES BY MICRORNA EXPRESSION 267
Carme Camps, Adrian L. Harris, and Jiannis Ragoussis
17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287
Claudia Piovan and Marilena V. Iorio
18 MICRORNAS IN HUMAN PROSTATE CANCER: FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311
Mustafa Ozen and Omer Faruk Karatas
19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329
Katrin Pfütze, Xiaoya Luo, and Barbara Burwinkel
20 GENETIC VARIATIONS IN MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER SUSCEPTIBILITY AND SURVIVAL 343
Ming Yang and Dongxin Lin
21 MICRORNA IN MYELOPOIESIS AND MYELOID DISORDERS 353
Sara E. Meyer and H. Leighton Grimes
22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC LEUKEMIA 371
Xabier Agirre and Felipe Prósper
23 ROLE OF MIRNAS IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383
Veronica Balatti, Yuri Pekarsky, Lara Rizzotto, and Carlo M. Croce
24 MICRORNA IN B-CELL NON-HODGKIN’S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403
Nerea Martínez, Lorena Di Lisio, and Miguel Angel Piris
25 MICRORNAS IN DIFFUSE LARGE B-CELL LYMPHOMA 419
Izidore S. Lossos and Alvaro J. Alencar
26 THE ROLE OF MICRORNAS IN HODGKIN’S LYMPHOMA 435
Wouter Plattel, Joost Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg
27 MICRORNA EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449
Cornelis P. Tensen
PART IV: HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463
28 MICRORNAS AND HEREDITARY DISORDERS 465
Matías Morín and Miguel A. Moreno-Pelayo
29 MICRORNAS AND CARDIOVASCULAR DISEASES 477
Koh Ono
30 MICRORNAS AND DIABETES 495
Romano Regazzi
31 MICRORNAS IN LIVER DISEASES 509
Patricia Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M. Banales
32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523
Andreas Junker
33 THE ROLE OF MICRORNAS IN ALZHEIMER’S DISEASE 539
Shahar Barbash and Hermona Soreq
34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553
Aoife Kearney, Javier A. Bravo, and Timothy G. Dinan
PART V: CIRCULATING MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567
35 CIRCULATING MICRORNAS AS NON-INVASIVE BIOMARKERS 569
Heidi Schwarzenbach and Klaus Pantel
36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589
Kasey C. Vickers
37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND METASTASIS IN RENAL CARCINOMA 607
Federica Collino, Cristina Grange, and Giovanni Camussi
PART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT PERSPECTIVES AND FUTURE DIRECTIONS 623
38 MICRORNA REGULATION OF CANCER STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625
Can Liu and Dean G. Tang
39 THERAPEUTIC MODULATION OF MICRORNAS 639
Achim Aigner and Hannelore Dassow
40 LOCKED NUCLEIC ACIDS AS MICRORNA THERAPEUTICS 663
Henrik Ørum
Index 673
