The Fifth Edition of Antimicrobial Therapy in Veterinary Medicine, the most comprehensive reference available on veterinary antimicrobial drug use, has been thoroughly revised and updated to reflect the rapid advancements in the field of antimicrobial therapy. Encompassing all aspects of antimicrobial drug use in animals, the book provides detailed coverage of virtually all types of antimicrobials relevant to animal health. Now with a new chapter on antimicrobial therapy in zoo animals, Antimicrobial Therapy in Veterinary Medicine offers a wealth of invaluable information for appropriately prescribing antimicrobial therapies and shaping public policy.
Divided into four sections covering general principles of antimicrobial therapy, classes of antimicrobial agents, special considerations, and antimicrobial drug use in multiple animal species, the text is enhanced by tables, diagrams, and photos. Antimicrobial Therapy in Veterinary Medicine is an essential resource for anyone concerned with the appropriate use of antimicrobial drugs, including veterinary practitioners, students, public health veterinarians, and industry and research scientists.
Table of Contents
Contributors ix
Preface xiii
Important Notice xv
Abbreviations xvii
Section I General Principles of Antimicrobial Therapy 1
1 Antimicrobial Drug Action and Interaction: An Introduction 3
Steeve Giguère
2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 11
Joseph E. Rubin
3 Antimicrobial Resistance and its Epidemiology 21
Patrick Boerlin and David G. White
4 Principles of Antimicrobial Drug Bioavailability and Disposition 41
J. Desmond Baggot and Steeve Giguère
5 The Pharmacodynamics of Antimicrobial Agents 79
Marilyn N. Martinez, Pierre-Louis Toutain, and John Turnidge
6 Principles of Antimicrobial Drug Selection and Use 105
Steeve Giguère
7 Antimicrobial Stewardship in Animals 117
J. Scott Weese, Stephen W. Page, and John F. Prescott
Section II Classes of Antimicrobial Agents 133
8 Beta-lactam Antibiotics: Penam Penicillins 135
John F. Prescott
9 Beta-lactam Antibiotics: Cephalosporins 153
John F. Prescott
10 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 175
John F. Prescott
11 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 189
Patricia M. Dowling
12 Lincosamides, Pleuromutilins, and Streptogramins 199
Steeve Giguère
13 Macrolides, Azalides, and Ketolides 211
Steeve Giguère
14 Aminoglycosides and Aminocyclitols 233
Patricia M. Dowling
15 Tetracyclines 257
Jérôme R.E. del Castillo
16 Chloramphenicol, Thiamphenicol, and Florfenicol 269
Patricia M. Dowling
17 Sulfonamides, Diaminopyrimidines, and Their Combinations 279
John F. Prescott
18 Fluoroquinolones 295
Steeve Giguère and Patricia M. Dowling
19 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 315
Patricia M. Dowling
20 Antifungal Chemotherapy 333
Steeve Giguère
Section III Special Considerations_357
21 Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy for the Neutropenic Patient 359
Steeve Giguère, Anthony C.G. Abrams-Ogg, and Stephen A. Kruth
22 Performance Uses of Antimicrobial Agents and Non-antimicrobial Alternatives 379
Thomas R. Shryock and Stephen W. Page
23 Antimicrobial Therapy of Selected Organ Systems 395
Patricia M. Dowling
24 Antimicrobial Therapy of Selected Bacterial Infections 421
Steeve Giguère
25 Antimicrobial Drug Residues in Foods of Animal Origin 431
Patricia M. Dowling
26 Regulation of Antimicrobial Use in Animals 443
Karolina Törneke and Christopher Boland
Section IV A ntimicrobial Drug Use in Selected Animal Species 455
27 Antimicrobial Drug Use in Horses 457
Steeve Giguère and Tiago Afonso
28 Antimicrobial Drug Use in Dogs and Cats 473
Jane E. Sykes
29 Antimicrobial Drug Use in Cattle 495
Michael D. Apley and Johann F. Coetzee
30 Antimicrobial Drug Use in Mastitis 519
Sarah Wagner and Ron Erskine
31 Antimicrobial Drug Use in Sheep and Goats 529
Chris R. Clark
32 Antimicrobial Drug Use in New World Camelids 541
Christopher K. Cebra and Margaret L. Cebra
33 Antimicrobial Drug Use in Swine 553
David G.S. Burch
34 Antimicrobial Drug Use in Poultry 569
Charles L. Hofacre, Jenny A. Fricke, and Tom Inglis
35 Antimicrobial Drug Use in Companion Birds 589
Keven Flammer
36 Antimicrobial Drug Use in Rabbits, Rodents, and Ferrets 601
Colette L. Wheler
37 Antimicrobial Drug Use in Reptiles 623
Ramiro Isaza and Elliott R. Jacobson
38 Antimicrobial Drug Use in Zoological Animals 637
Ellen Wiedner and Robert P. Hunter
39 Antimicrobial Drug Use in Aquaculture 645
Renate Reimschuessel, Ron A. Miller, and Charles M. Gieseker
Index 663
