Ideal as a graduate textbook, this title is aimed at helping design effective biomaterials, taking into account the complex interactions that occur at the interface when a synthetic material is inserted into a living system. Surface reactivity, biochemistry, substrates, cleaning, preparation, and coatings are presented, with numerous case studies and applications throughout.
Highlights include:
- Starts with concepts and works up to real-life applications such as implantable devices, medical devices, prosthetics, and drug delivery technology
- Addresses surface reactivity, requirements for surface coating, cleaning and preparation techniques, and characterization
- Discusses the biological response to coatings
- Addresses biomaterial-tissue interaction
- Incorporates nanomechanical properties and processing strategies
Table of Contents
Chapter 1. Introduction to Biomaterials
1.1 Introduction
1.2 Summary
Chapter 2. Tissue Interaction with Biomaterials
2.1 Introduction
2.2 Protein adsorption and Cell adhesion
2.3 Cell Migration
2.4 Controlled Cell Deposition
2.5 Extracellular Matrix
2.6 Biomineralization
Chapter 3. Host Response of Implanted Biomaterials
3.1 Immune Response to Implanted Biomaterials
3.2 Transplant Immunology
3.3 Biocomaptibility
Chapter 4. Fundamentals of Surface Modification
4.1 Introduction
4.2 Surface Properties of Biomaterials
4.3 Surface modifications
4.4 Applications
Chapter 5. Multi Length Scale Hierarchy in Natural Materials
5.1 Introduction
5.2 Multi Length-scale Hierarchy
5.3 Human Bone
5.4 Turtle shell
5.5 Wood
5.6 Silk
5.7 Nacre
5.8 Gecko-feet
5.9 Lotus Leaf
Chapter 6. Superhydrophobic Surfaces
6.1 Introduction
6.2 Surfaces and superhydrophobicity in nature
6.3 Classification of surfaces
6.4 Mechanics and nature of wetting
6.5 Fabrication of artificial superhydrophobic surfaces
6.6 Preparation of metallic superhydrophobic surfaces
6.7 Controlled wettability surfaces (CWS)
6.8 Conclusions
Chapter 7. Surface Engineering and Modification for Biomedical Applications
7.1 Corrosion of Biomaterials and Need for Surface Coating for Biomedical Applications
7.2 Surface Reactivity and Body Cell Response
7.3 Key Requirements of Surface Coating
7.4 Key Biomaterial Substrates
7.5 Surface Preparation and Cleaning Techniques
7.6 Surface Engineering and Coating Techniques
7.7 Coatings for Biomedical Applications
7.8. Biosurface Characterization
Chapter 8. Laser Engineering of Surface Structures
8.1 Introduction
8.2 Laser processing of biomaterials
8.3 Laser-based prototyping methods
8.4 Ultrafast laser pulses
8.5 Neural implants
8.6 Ophthalmic implants
8.7 Laser fabrication of cardiovascular devices
8.8 Laser-fabricated nanoscale materials
8.9 Two photon polymerization
8.10 Microneedle fabrication
8.11 Conclusions
Chapter 9. Processing and Nanomechanical Properties of Hydroxyapatite-Nanotube Biocomposite
9.1 Introduction
9.2 Processing of HA-Carbon Nanotube Composites
9.3 Fracture Toughness and Tribological Properties of HA-Carbon Nanotube Composites
9.4 Adhesion of Bone Forming Cells on HA-CNT Surface
9.5 Biomechanical Compatibility at Bone/Coated Implant Interface
9.6 HA-Boron Nitride Nano Tube (BNNT) Composites
9.7 HA-TiO2 Nanotube Composites
9.8 Summary
Chapter 10. Applications of Biomaterials
10.1 Multi-scale hierarchy in natural Bone
10.2 Coronary Stents
10.3 Medical Devices
10.4 Drug Delivery
Chapter 11. Nanosafety, Nanosocietal and Nanoethical Issues
11.1 Governmental Environment and Health Safety Organization Protocols
11.2 Related Safety Hazards
11.3 Approach to Developing Safety Protocol for Laboratory Environment
11.4 Tendency of Nanoparticles
11.5 Current Capability of Nanoparticle Filters
