Nanoparticle therapeutics: Production Technologies, Types of Nanoparticles, and Regulatory Aspects employs unique principles for applications in cell-based therapeutics, diagnostics and mechanistics for the study of organ physiology, disease etiology and drug screening of advanced nanoparticles and nanomaterials. The book focuses on the extrapolation of bioengineering tools in the domain of nanotechnology and nanoparticles therapeutics, fabrication, characterization and drug delivery aspects. It acquaints scientists and researchers on the experiential and experimental aspects of nanoparticles and nanotechnology to equip their rational application in various fields, especially in differential diagnoses and in the treatment of diverse diseased states.
This complete resource provides a holistic understanding of the principle behind formation, characterization, applications, regulations and toxicity of nanoparticles employing myriad principles of nanotechnology. Investigators, pharmaceutical researchers, and advanced students working on technology advancement in the areas of designing targeted therapies, nanoscale imaging systems and diagnostic modalities in human diseases where nanoparticles can be used as a critical tool for technology advancement in drug delivery systems will find this book useful.
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Table of Contents
Part 1: Synthesis and characterization of NP for drug delivery1. Nanoparticles: Recent state-of-art and prospective challenges2. Fabrication, process technologies and challenges in development of nanoparticles3. In vitro and physicochemical characterization of nanoparticles4. Surface-engineering of nanoparticles for imparting multifuntionality5. Biofate and cellular interactions of nanoparticles6. Pharmacokinetics and in vivo evaluation of nanoparticles
Part 2: Application of Nanoparticles in Drug Delivery7. Biodegradable polymeric nanoparticles for sustained drug delivery8. Lipidic nanoparticles with improved biopharmaceutical attributes9. Protein-based nanoparticles for drug delivery10. Gold and silver nanoparticles for drug delivery11. Mesoporous silica and silicates nanoparticles for drug delivery12. Targeted nanosuspensions for improved therapeutics13. SPIONS as therapeutic and diagnostic agents14. Bio-inspired nanoparticles/exosomes vesicles as drug delivery vehicles
Part 3: Environmental and Regulatory Aspects14. Regulatory pathways and federal perspectives on nanoparticles15. Environmental hazards associated with nanoparticles16. Biological toxicity of nanoparticles
Authors
Prashant Kesharwani Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.Dr. Prashant Kesharwani is an assistant professor of pharmaceutics at School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 300 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as "USERN Laureate award�, most prestigious "Ramanujan Fellowship Award�. He actively participates in outreach and scientific dissemination for the service of the wider community.
Kamalinder K. Singh Professor of Pharmaceutical Technology and Drug Delivery, School of Pharmacy and Biomedical Sciences, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Preston, UK. Prof Kamalinder K Singh is Professor of Pharmaceutical Technology & Drug Delivery and Research Lead at the School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, United Kingdom and heads the Nanomedicine and Innovative technologies research group within the Faculty of Clinical and Biomedical Sciences and is Healthcare Lead for UCLan Centre of Smarts Materials. With more than 35 years' experience in academia, Prof Singh has contributed significantly to the field of pharmaceutical technology, drug delivery and nanomedicine through authorship of over 80 research articles, 18 patents, 12 book chapters and 60 monographs. Her pioneering research has led to development of many biocompatible nanoparticle-based platform technologies exploiting to deliver drugs across various biological barriers with application to human health and diseases. Prof Singh serves on International Steering Committee for 'Handbook of Pharmaceutical Excipients', joint publication by AAPS, Pharmaceutical Press, and Royal Pharmaceutical Society, Great Britain. She has provided leadership to 35 major funded research projects and is currently managing several research projects funded by National Institute of Health, Academy of Medical Sciences, British Council and UK Foreign Commonwealth and Development Office. She has supervised 30 ECRs and delivered more than 70 keynotes and invited talks at prestigious forums around the globe.
