Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.
Macrophages in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential.
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Table of Contents
1. Ontogeny of macrophages
2. Differentiation of macrophages
3. Metabolic requirement for macrophages
4. Sensor and effector mechanisms of macrophages
5. Spleen, lymph nodes and lymphoid tissues
Inflammatory system
6. Kidney
Inflammatory and remodeling system
7. Skin
Inflammatory and epithelial system
8. Bones and cartilage
Inflammatory and skeletal system
9. Brain
Inflammatory and nervous system
10. Intestines
Inflammatory and digestive system
11. Lungs
Inflammatory and respiratory system
12. Liver
Inflammatory and liver system
13. Heart and vessels
Inflammatory and cardiovascular system
14. Male and female reproductive organs
Inflammatory and reproductive system
15. Targeting macrophages in systemic diseases