This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of genitourinary pathology, it incorporates the most recent clinical, pathologic, staging, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Genitourinary is a one-stop reference for accurate, complete surgical pathology reporting, ideal as a day-to-day reference or as a reliable training resource.
- Covers nearly 200 diagnoses of the kidney, bladder, prostate, testis, paratestis, and penis, including details on the rapid changes and continuous advances in the diagnosis of genitourinary cancers
- Includes the latest WHO (2022) and AFIP classifications/nomenclatures of tumors of the kidney, bladder, prostate, testis, and paratestis, as well as updated general concepts
- Features thousands of extensively annotated images, including gross pathology photographs, histopathology photomicrographs with a wide range of stains, and full-color illustrations
- Contains the latest staging information released in the most recent AJCC Cancer Staging Manual with a focus on practical issues pertaining to pathologic staging in resection specimens
- Provides expert guidance on differential diagnostic mimics in the text, as well as in the image galleries (unique to this book)
- Covers new and clinically relevant immunohistochemical (IHC) markers
- Provides relevant details and updates from the multiomic (or whole-genome) approach as relevant to pathology practice
- Discusses the latest changes in precision medicine and continuous advances in oncology research, including the discovery of new urologic cancer biomarkers
- Features a templated, highly formatted design and concise, bulleted text; diagnostic pearls, key facts in each chapter; and an extensive index for easy reference
- Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
Table of Contents
SECTION 1: KIDNEYIntroduction and Overview
4 Introduction to Renal Cell Tumors
Satish K. Tickoo, MD and Victor E. Reuter, MD
10 Classification of Kidney Tumors and Tumor-Like Lesions
Satish K. Tickoo, MD and Victor E. Reuter, MD
Familial Cancer Syndromes
12 von Hippel-Lindau Syndrome
Satish K. Tickoo, MD and Victor E. Reuter, MD
16 Birt-Hogg-Dub? Syndrome
Satish K. Tickoo, MD and Victor E. Reuter, MD
20 Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome
Satish K. Tickoo, MD, Victor E. Reuter, MD, and Mahul B. Amin, MD
24 Tuberous Sclerosis Complex
Satish K. Tickoo, MD and Victor E. Reuter, MD
28 Succinate Dehydrogenase Complex Deficiency Syndrome
Satish K. Tickoo, MD and Victor E. Reuter, MD
32 Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer Syndromes
Satish K. Tickoo, MD and Victor E. Reuter, MD
Nonneoplastic Lesions
38 Renal Tuberculosis, Xanthogranulomatous Pyelonephritis, Renal Malakoplakia
Satish K. Tickoo, MD and Victor E. Reuter, MD
Renal Cell Tumors, Benign
44 Papillary Adenoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
48 Renal Oncocytoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
Renal Cell Carcinoma
54 Clear Cell Renal Cell Carcinoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
64 Multilocular Cystic Renal Neoplasm of Low Malignant Potential
Satish K. Tickoo, MD and Victor E. Reuter, MD
68 Clear Cell Renal Cancers With Fibromyomatous Stroma, Including ELOC (Formerly TCEB1) Mutated Renal Cell Carcinoma
Judy Sarungbam, MD, Satish K. Tickoo, MD, and Victor E. Reuter, MD
74 Clear Cell Papillary Renal Cell Tumor
Satish K. Tickoo, MD and Victor E. Reuter, MD
82 Papillary Renal Cell Carcinoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
92 Chromophobe Renal Cell Carcinoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
100 Collecting Duct Carcinoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
106 SMARCB1-Deficient Renal Medullary Carcinoma and SMARCB1-Deficient Medullary-Like Renal Cell Carcinoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
112 TFE3- and TFEB-Rearranged Renal Cell Carcinomas
Satish K. Tickoo, MD and Victor E. Reuter, MD
120 Mucinous Tubular and Spindle Cell Carcinoma
Satish K. Tickoo, MD, Yingbei Chen, MD, and Victor E. Reuter, MD
126 Tubulocystic Renal Cell Carcinoma
Satish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MD
130 Thyroid-Like Follicular Carcinoma of Kidney
Satish K. Tickoo, MD and Victor E. Reuter, MD
134 Acquired Cystic Disease-Associated Renal Cell Carcinoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
140 Fumarate Hydratase-Deficient Renal Cell Carcinoma
Jatin S. Gandhi, MD and Mahul B. Amin, MD
144 ALK Rearrangement-Associated Renal Cell Carcinoma
Jatin S. Gandhi, MD and Mahul B. Amin, MD
148 Eosinophilic Solid and Cystic Renal Cell Carcinoma
Jatin S. Gandhi, MD and Mahul B. Amin, MD
150 Other Eosinophilic/Oncocytic Tumors, Including ESC, EVT, and LOT
Satish K. Tickoo, MD and Victor E. Reuter, MD
154 Subsequent 2nd Tumors
Satish K. Tickoo, MD and Victor E. Reuter, MD
158 Renal Cell Carcinoma, Not Otherwise Specified
Satish K. Tickoo, MD and Victor E. Reuter, MD
Metanephric Tumors
162 Metanephric Adenoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
168 Metanephric Tumors Other Than Metanephric Adenoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
Nephroblastic Tumors
172 Nephrogenic Rests
Satish K. Tickoo, MD and Victor E. Reuter, MD
176 Nephroblastoma (Wilms Tumor)
Satish K. Tickoo, MD and Victor E. Reuter, MD
186 Cystic Partially Differentiated Nephroblastoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
Mesenchymal Tumors
188 Angiomyolipoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
194 Epithelioid Angiomyolipoma/Epithelioid PEComa
Satish K. Tickoo, MD and Victor E. Reuter, MD
200 Congenital Mesoblastic Nephroma
Satish K. Tickoo, MD and Victor E. Reuter, MD
204 Clear Cell Sarcoma of Kidney
Satish K. Tickoo, MD and Victor E. Reuter, MD
208 Rhabdoid Tumor of Kidney
Satish K. Tickoo, MD and Victor E. Reuter, MD
Mixed Mesenchymal and Epithelial Tumors
212 Mixed Epithelial and Stromal Tumor (MEST) Family Tumors
Satish K. Tickoo, MD and Victor E. Reuter, MD
220 Pediatric Cystic Nephroma
Satish K. Tickoo, MD and Victor E. Reuter, MD
224 Synovial Sarcoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
Neuroendocrine Tumors
228 Renal Neuroendocrine Tumor/Carcinoid Tumor and Neuroendocrine Carcinoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
232 Renal Ewing Sarcoma
Satish K. Tickoo, MD and Victor E. Reuter, MD
Hematopoietic Tumors
236 Hematopoietic Tumors
Satish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MD
Metastatic and Other Tumors
242 Juxtaglomerular Cell Tumor (Reninoma)
Satish K. Tickoo, MD and Victor E. Reuter, MD
246 Renomedullary Interstitial Cell Tumor
Satish K. Tickoo, MD and Victor E. Reuter, MD
250 Other Rare Tumors
Satish K. Tickoo, MD and Victor E. Reuter, MD
258 Metastatic Tumors
Satish K. Tickoo, MD and Victor E. Reuter, MD
Immunohistochemical Profiles for Tumors Involving Kidney
262 Immunohistochemistry, Kidney
Satish K. Tickoo, MD and Victor E. Reuter, MD
SECTION 2
Introduction and Overview
270 Classification of Bladder Tumors and Tumor-Like Lesions
Steven Christopher Smith, MD, PhD
Microscopic Anatomy
272 Microscopic Anatomy of Urinary Bladder
Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD
276 Microscopic Anatomy of Urethra
Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD
280 Microscopic Anatomy of Ureter
Steven Christopher Smith, MD, PhD
282 Microscopic Anatomy of Renal Pelvis
Steven Christopher Smith, MD, PhD
Nonneoplastic Lesions of Urinary Tract
286 Overview of Cystitis
Steven Christopher Smith, MD, PhD
292 Polypoid Cystitis
Steven Christopher Smith, MD, PhD
300 Malakoplakia
Steven Christopher Smith, MD, PhD
306 Schistosomiasis
Steven Christopher Smith, MD, PhD
308 von Brunn Nests
Steven Christopher Smith, MD, PhD
314 Nephrogenic Adenoma (Metaplasia)
Steven Christopher Smith, MD, PhD
322 Fibroepithelial Polyp
Steven Christopher Smith, MD, PhD
326 Prostatic-Type Polyp (Ectopic Prostate)
Steven Christopher Smith, MD, PhD
330 Amyloidosis
Steven Christopher Smith, MD, PhD
332 M?llerian Lesions
Steven Christopher Smith, MD, PhD
336 Pseudocarcinomatous Hyperplasia
Steven Christopher Smith, MD, PhD
344 Hamartoma
Steven Christopher Smith, MD, PhD
Urothelial Neoplasms, General
346 Overview of Urinary Bladder Neoplasms
Hikmat Al-Ahmadie, MD
Flat Urothelial Lesions
350 Urothelial Carcinoma In Situ
Steven Christopher Smith, MD, PhD
358 Flat Urothelial Lesions Other Than Carcinoma In Situ
Steven Christopher Smith, MD, PhD
UROTHELIAL NEOPLASMS, NONINVASIVE
362 Atypical Urothelial Proliferations, Flat and Tented Type (Formerly Flat and Papillary Hyperplasia)
Jatin S. Gandhi, MD and Mahul B. Amin, MD
364 Urothelial Papilloma
Steven Christopher Smith, MD, PhD
370 Papillary Urothelial Neoplasm of Low Malignant Potential
Steven Christopher Smith, MD, PhD
374 Low-Grade Papillary Urothelial Carcinoma
Hikmat Al-Ahmadie, MD
378 High-Grade Papillary Urothelial Carcinoma
Hikmat Al-Ahmadie, MD
384 Inverted Urothelial Neoplasia
Steven Christopher Smith, MD, PhD
Urothelial Neoplasms, Invasive
394 Invasive Urothelial Carcinoma
Hikmat Al-Ahmadie, MD
404 Urothelial Carcinoma, Subtypes and Divergent Differentiation
Steven Christopher Smith, MD, PhD
Glandular Lesions
426 Cystitis Cystica et Glandularis
Hikmat Al-Ahmadie, MD
430 Villous Adenoma
Hikmat Al-Ahmadie, MD
432 Invasive Adenocarcinoma
Hikmat Al-Ahmadie, MD
438 Clear Cell Adenocarcinoma
Hikmat Al-Ahmadie, MD
Squamous Lesions
444 Squamous Proliferations Other Than Carcinoma
Hikmat Al-Ahmadie, MD
448 Invasive Squamous Cell Carcinoma
Hikmat Al-Ahmadie, MD
Mesenchymal Lesions
454 Myofibroblastic Proliferations
Steven Christopher Smith, MD, PhD
462 Smooth Muscle Tumors
Steven Christopher Smith, MD, PhD
470 Rhabdomyosarcoma
Steven Christopher Smith, MD, PhD
476 Other Mesenchymal Tumors
Steven Christopher Smith, MD, PhD
Other Tumors of Urinary Bladder
484 Paraganglioma
Steven Christopher Smith, MD, PhD
492 Metastatic/Secondary Involvement of Bladder
Steven Christopher Smith, MD, PhD
Diverticula of Urinary Tract
500 Diverticula
Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD
504 Diverticular-Associated Neoplasia
Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD
URETHRA
508 Inflammatory Lesions of Urethra
Steven Christopher Smith, MD, PhD
512 Carcinoma of Urethra
Steven Christopher Smith, MD, PhD
516 Other Tumors and Tumor-Like Lesions of Urethra
Steven Christopher Smith, MD, PhD
URETER
520 Urothelial Carcinoma of Ureter
Hikmat Al-Ahmadie, MD
524 Other Tumors and Tumor-Like Lesions of Ureter
Hikmat Al-Ahmadie, MD
RENAL PELVIS
530 Urothelial Carcinoma of Renal Pelvis
Hikmat Al-Ahmadie, MD
540 Other Tumors and Tumor-Like Lesions of Renal elvis
Hikmat Al-Ahmadie, MD
Urachs
546 Urachal Remnants
Steven Christopher Smith, MD, PhD
548 Tumors of Urachus
Steven Christopher Smith, MD, PhD
Immunohistochemical Profiles for Tumors Involving Urinary Bladder
554 Immunohistochemistry, Urinary Tract
Steven Christopher Smith, MD, PhD
SECTION 3: PROSTATE GLAND AND SEMINAL VESICLE
Introduction and Overview
562 Classification of Prostate Tumors and Tumor-Like Lesions
Gladell P. Paner, MD, (BS) MT
564 General Concepts, Prostate
Gladell P. Paner, MD, (BS) MT
570 Microanatomy and Zonal Variations
Gladell P. Paner, MD, (BS) MT
580 Imaging Considerations for Pathologists
Steven Christopher Smith, MD, PhD
NONNEOPLASTIC LESIONS
584 Prostatitis
Steven Christopher Smith, MD, PhD
588 Prostate Hyperplasia
Gladell P. Paner, MD, (BS) MT
596 Adenosis
Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD
600 Atrophy and Its Patterns
Gladell P. Paner, MD, (BS) MT
606 Hyperplasia of Mesonephric Remnants
Steven Christopher Smith, MD, PhD
610 Verumontanum Mucosal Gland Hyperplasia
Gladell P. Paner, MD, (BS) MT and Deepika Sirohi, MD
612 Nephrogenic Adenoma (Metaplasia) of Prostatic Urethra
Gladell P. Paner, MD, (BS) MT
PUTATIVE PREMALIGNANT LESIONS AND LESIONS FALLING SHORT OF MALIGNANT DIAGNOSIS
620 Prostatic Intraepithelial Neoplasia
Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD
Prostate Neoplasms
630 General Concepts, Prostate Carcinoma
Steven Christopher Smith, MD, PhD
638 Acinar Adenocarcinoma
Gladell P. Paner, MD, (BS) MT
656 Acinar Adenocarcinoma Subtypes and Patterns
Gladell P. Paner, MD, (BS) MT
668 Atypical Small Acinar Proliferations
Steven Christopher Smith, MD, PhD
674 Intraductal Proliferations and Ductal Carcinoma
Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD
682 Ductal Adenocarcinoma
Gladell P. Paner, MD, (BS) MT
690 Urothelial Carcinoma Involving Prostate Gland
Steven Christopher Smith, MD, PhD
696 Prostate Carcinoma With Neuroendocrine Differentiation
Steven Christopher Smith, MD, PhD
704 Adenoid Cystic (Basal Cell) Carcinoma of Prostate
Steven Christopher Smith, MD, PhD
710 Sarcomatoid Carcinoma of Prostate
Steven Christopher Smith, MD, PhD
716 Carcinomas With Squamous Differentiation
Gladell P. Paner, MD, (BS) MT
722 Cystic Epithelial Tumors of Prostate
Gladell P. Paner, MD, (BS) MT
724 Stromal Tumors
Gladell P. Paner, MD, (BS) MT
732 Mesenchymal Tumors of Prostate
Gladell P. Paner, MD, (BS) MT
740 Melanocytic Lesions of Prostate
Gladell P. Paner, MD, (BS) MT
744 Hematopoietic Neoplasms of Prostate
Gladell P. Paner, MD, (BS) MT
748 Secondary Tumors of Prostate
Gladell P. Paner, MD, (BS) MT and Deepika Sirohi, MD
Tumors of Seminal Vesicle
752 Mixed Epithelial and Stromal Tumor
Steven Christopher Smith, MD, PhD
756 Seminal Vesicle Adenocarcinoma
Gladell P. Paner, MD, (BS) MT
Immunohistochemical Profiles for Tumors and Tumor-Like Lesions Involving Prostate Gland
758 Immunohistochemistry, Prostate
Steven Christopher Smith, MD, PhD
SECTION 4: TESTIS AND PARATESTICULAR STRUCTURES
Introduction and Overview
766 Classification of Testis and Paratestis Tumors and Tumor-Like Lesions
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
Nonneoplastic Lesions
768 Cryptorchidism
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
772 Sertoli Cell-Only Syndrome
Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD
776 Nontuberculous Infections
Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD
778 Nonspecific Granulomatous Orchitis
Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD
780 Tuberculous Epididymo-Orchitis
Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD
Germ Cell Tumors
782 General Concepts, Germ Cell Tumors
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
Germ Cell Tumors Related to Germ Cell Neoplasia In Situ
790 Germ Cell Neoplasia In Situ
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
796 Seminoma
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
804 Intratubular Seminoma
Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD
806 Intratubular Embryonal Carcinoma
Steven S. Shen, MD, PhD
808 Embryonal Carcinoma
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
814 Yolk Sac Tumor
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
822 Choriocarcinoma and Other Trophoblastic Tumors
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
828 Postpubertal-Type Teratoma
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
832 Mixed Germ Cell Tumors
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
836 Somatic-Type Malignancy in Germ Cell Tumor
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
838 Burnt-Out (Regressed) Germ Cell Tumor
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
Germ Cell Tumors Unrelated to Germ Cell Neoplasia In Situ
840 Spermatocytic Tumor
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
844 Pediatric Germ Cell Tumor, General Concepts
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
846 Prepubertal-Type Teratoma
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
850 Yolk Sac Tumor, Prepubertal Type
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
854 Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type
Muhammad T. Idrees, MD
856 Well-Differentiated Neuroendocrine Tumor (Monodermal Teratoma)
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
Sex Cord-/Gonadal Stromal Tumors
860 General Concepts, Sex Cord-/Gonadal Stromal Tumors
Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and Jae Y. Ro, MD, PhD
868 Leydig Cell Tumors
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, Mukul K. Divatia, MD, and Jae Y. Ro, MD, PhD
872 Sertoli Cell Tumors
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, Mukul K. Divatia, MD, and Jae Y. Ro, MD, PhD
878 Large Cell Calcifying Sertoli Cell Tumor
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
882 Intratubular Large Cell Hyalinizing Sertoli Cell Tumor
Mukul K. Divatia, MD, Steven S. Shen, MD, PhD, and Muhammad T. Idrees, MD
884 Granulosa Cell Tumor
Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and Muhammad T. Idrees, MD
888 Juvenile Granulosa Cell Tumor
Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and Muhammad T. Idrees, MD
892 Fibroma-Thecoma
Mukul K. Divatia, MD, Steven S. Shen, MD, PhD, and Jae Y. Ro, MD, PhD
894 Myoid Gonadal Stromal Tumor
Muhammad T. Idrees, MD
896 Signet-Ring Stromal Tumors
Muhammad T. Idrees, MD
898 Testicular Tumor of Adrenogenital Syndrome
Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD
902 Sex Cord-Stromal Tumor, Mixed/Unclassified
Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and
Muhammad T. Idrees, MD
906 Gonadoblastoma
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
Hematopoietic Tumors
910 Lymphoma/Leukemia/Plasmacytoma
Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD
Tumors Of Paratesticular Structures
916 Adenomatoid Tumor
Steven S. Shen, MD, PhD, Jae Y. Ro, MD, PhD, and Muhammad T. Idrees, MD
920 Well-Differentiated Papillary Mesothelial Tumor
Muhammad T. Idrees, MD
922 Malignant Mesothelioma
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
926 Adenocarcinoma of Rete Testis/Epididymis
Steven S. Shen, MD, PhD, Jae Y. Ro, MD, PhD, and Muhammad T. Idrees, MD
928 Epididymal Tumors
Muhammad T. Idrees, MD
930 Ovarian Epithelial-Type Tumors
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
934 Liposarcoma
Mukul K. Divatia, MD, Steven S. Shen, MD, PhD, and Jae Y. Ro, MD, PhD
940 Melanotic Neuroectodermal Tumor
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
944 Rhabdomyosarcoma
Mukul K. Divatia, MD, Steven S. Shen, MD, PhD, and Jae Y. Ro, MD, PhD
950 Other Sarcomas
Steven S. Shen, MD, PhD, Muhammad T. Idrees, MD, and Jae Y. Ro, MD, PhD
Metastatic Tumors, Testis and Paratesticular Structures
954 Metastatic Tumors, Testis and Paratesticular Structures
Steven S. Shen, MD, PhD and Jae Y. Ro, MD, PhD
Immunohistochemical Profiles for Tumors Involving Testis and Paratesticular Structures
958 Immunohistochemistry, Testis
Steven S. Shen, MD, PhD, Mukul K. Divatia, MD, and Jae Y. Ro, MD, PhD
SECTION 5: PENIS AND SCROTUM
Frequent Lesions of Uncertain Relationship to Penile Neoplasia
968 Condyloma
Mar?a Jos? Fern?ndez De Nestosa, PhD
972 Lichen Sclerosus et Atrophicus
Elsa F. Velazquez, MD, Sof?a Ca?ete-Portillo, MD, and Antonio L. Cubilla, MD
974 Squamous Hyperplasia
Sof?a Ca?ete-Portillo, MD, Diego Fernando S?nchez Mart?nez, MD, and Antonio L. Cubilla, MD
978 Lipogranuloma
Elsa F. Velazquez, MD and Antonio L. Cubilla, MD
980 Scrotal Calcinosis
Elsa F. Velazquez, MD and Antonio L. Cubilla, MD
Penile Intraepithelial Neoplasia
982 Penile Intraepithelial Neoplasia
Elsa F. Velazquez, MD, Diego Fernando S?nchez Mart?nez, MD, and Antonio L. Cubilla, MD
Primary Epithelial Tumors
988 General Concepts, Squamous Cell Carcinoma (Including Staging and Molecular Pathology)
Antonio L. Cubilla, MD, Diego Fernando S?nchez Mart?nez, MD, Sof?a Ca?ete-Portillo, MD, Mahul B. Amin, MD, and Elsa F. Velazquez, MD
1002 Overview of HPV- and Non-HPV-Related Tumors
Mar?a Jos? Fern?ndez De Nestosa, PhD, Diego Fernando S?nchez Mart?nez, MD, Mahul B. Amin, MD, and Antonio L. Cubilla, MD
Squamous Cell Carcinoma and Its Subtypes
1006 Squamous Cell Carcinoma, Usual Type
Antonio L. Cubilla, MD, Diego Fernando S?nchez Mart?nez, MD, and Sof?a Ca?ete-Portillo, MD
1010 Basaloid Squamous Cell Carcinoma
Antonio L. Cubilla, MD, Diego Fernando S?nchez Mart?nez, MD, and Sof?a Ca?ete-Portillo, MD
1014 Basaloid Squamous Cell Carcinoma, Papillary Subtype
Diego Fernando S?nchez Mart?nez, MD and Antonio L. Cubilla, MD
1016 Warty (Condylomatous) Squamous Cell Carcinoma
Elsa F. Velazquez, MD, Sof?a Ca?ete-Portillo, MD, and Antonio L. Cubilla, MD
1020 Warty-Basaloid Squamous Cell Carcinoma
Diego Fernando S?nchez Mart?nez, MD and Antonio L. Cubilla, MD
1022 Verrucous Squamous Cell Carcinoma
Elsa F. Velazquez, MD, Sof?a Ca?ete-Portillo, MD, and Antonio L. Cubilla, MD
1026 Papillary Squamous Cell Carcinoma, Not Otherwise Specified
Antonio L. Cubilla, MD, Diego Fernando S?nchez Mart?nez, MD, and Sof?a Ca?ete-Portillo, MD
1030 Pseudoglandular Squamous Cell Carcinoma
Diego Fernando S?nchez Mart?nez, MD and Antonio L. Cubilla, MD
1032 Pseudohyperplastic Squamous Cell Carcinoma
Antonio L. Cubilla, MD, Diego Fernando S?nchez Mart?nez, MD, and Sof?a Ca?ete-Portillo, MD
1034 Cuniculatum Squamous Cell Carcinoma
Antonio L. Cubilla, MD, Diego Fernando S?nchez Mart?nez, MD, and Sof?a Ca?ete-Portillo, MD
1038 Sarcomatoid Squamous Cell Carcinoma
Elsa F. Velazquez, MD, Sof?a Ca?ete-Portillo, MD, and Antonio L. Cubilla, MD
1042 Mixed Squamous Cell Carcinoma
Antonio L. Cubilla, MD, Diego Fernando S?nchez Mart?nez, MD, and Sof?a Ca?ete-Portillo, MD
1046 Undifferentiated to Poorly Differentiated Squamous Cell Carcinomas With Prominent Inflammatory Infiltrate
Diego Fernando S?nchez Mart?nez, MD and Antonio L. Cubilla, MD
1048 Clear Cell Carcinoma
Diego Fernando S?nchez Mart?nez, MD and Antonio L. Cubilla, MD
Other Neoplastic Conditions
1050 Extramammary Paget Disease
Elsa F. Velazquez, MD and Antonio L. Cubilla, MD
1054 Kaposi Sarcoma
Elsa F. Velazquez, MD, Jesse K. McKenney, MD, and
Antonio L. Cubilla, MD
1056 Myointimoma
Mahul B. Amin, MD and Jatin S. Gandhi, MD
Metastatic Tumors
1058 Metastatic Tumors, Penis
Antonio L. Cubilla, MD, Diego Fernando S?nchez Mart?nez, MD, and Sof?a Ca?ete-Portillo, MD
Immunohistochemical Profiles for Tumors Involving Penis
1060 Immunohistochemistry, Penis
Antonio L. Cubilla, MD
