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Protein Stability Analysis - Global Strategic Business Report

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    Report

  • 88 Pages
  • November 2024
  • Region: Global
  • Global Industry Analysts, Inc
  • ID: 5304109
The global market for Protein Stability Analysis was estimated at US$2.2 Billion in 2023 and is projected to reach US$4.0 Billion by 2030, growing at a CAGR of 8.5% from 2023 to 2030. This comprehensive report provides an in-depth analysis of market trends, drivers, and forecasts, helping you make informed business decisions.

Protein Stability Analysis: Ensuring Functionality and Longevity in Biopharmaceuticals and Beyond

What Is Protein Stability Analysis and Why Does It Matter?

Protein stability analysis is a critical process that assesses the structural integrity and functional longevity of a protein under various environmental conditions. Stability is essential for understanding how a protein will perform, especially in pharmaceutical and industrial applications where proteins are often exposed to different pH levels, temperatures, or mechanical stresses. Stable proteins maintain their structure and biological function over time, which is vital in drug development and manufacturing processes, where any degradation or unfolding could compromise efficacy and safety. Protein stability is also essential in research and therapeutic applications since an unstable protein may lose activity, aggregate, or trigger immune responses. Stability analysis thus helps ensure that proteins retain their desired properties under practical use conditions, facilitating the creation of robust and effective protein-based products.

How Is Protein Stability Measured?

Various methods are used to assess protein stability, with each technique offering insights into different aspects of structural integrity. Differential Scanning Calorimetry (DSC) measures the heat absorbed or released as a protein unfolds, providing a direct assessment of thermal stability. This method is valuable for determining the melting temperature (Tm), a key indicator of a protein's thermal resilience. Circular Dichroism (CD) Spectroscopy is another widely used technique that assesses secondary structure changes by measuring how proteins absorb circularly polarized light. CD spectroscopy is sensitive to minor conformational changes and can detect unfolding or aggregation events.

Dynamic Light Scattering (DLS) is used to evaluate protein aggregation by measuring particle size in solution, offering insights into a protein's propensity to aggregate over time. Fluorescence-based techniques, such as intrinsic fluorescence or Förster resonance energy transfer (FRET), provide high sensitivity to detect even minor unfolding events by monitoring the environment of aromatic residues like tryptophan. These techniques, often used in combination, provide a comprehensive view of a protein's stability, allowing researchers to identify vulnerabilities and optimize formulation conditions accordingly.

How Does Protein Stability Analysis Benefit Drug Development and Biotechnology?

In biopharmaceuticals, protein stability is paramount, as therapeutic proteins and antibodies need to remain stable and active throughout manufacturing, storage, and administration. Stability analysis allows developers to predict and mitigate potential degradation pathways, ensuring that biologic drugs retain their efficacy and do not form harmful aggregates. For example, antibody-based drugs undergo rigorous stability testing to assess their behavior under various pH levels and temperatures encountered during processing and storage. Stability analysis also aids in optimizing formulation conditions, such as choosing suitable excipients, stabilizers, and buffers that enhance protein stability.

Beyond pharmaceuticals, protein stability is crucial in industrial enzymes used in detergents, food processing, and biofuels, where they must withstand extreme conditions while maintaining activity. By analyzing stability, researchers can engineer proteins to increase their robustness, ensuring that they perform effectively in real-world applications and have a longer shelf life. This meticulous approach to stability ensures that protein-based products meet quality and safety standards across a wide range of industries.

What Are the Key Drivers in the Protein Stability Analysis Market?

The growth in the protein stability analysis market is driven by several factors, including advancements in analytical technology, increasing demand for biologics, and an emphasis on quality control. First, technological innovations in stability analysis, such as high-throughput screening, label-free methods, and automated systems, have made it faster and more efficient to analyze protein stability. These advancements enable detailed stability profiling during early-stage drug development, allowing for better candidate selection and reducing the risk of late-stage failures.

Additionally, the growing demand for biologics and biosimilars, especially in treating complex diseases like cancer and autoimmune disorders, has intensified the need for rigorous stability testing to ensure product efficacy and safety. Consumer expectations for high-quality protein-based products in sectors like food, cosmetics, and healthcare further drive this demand, particularly as regulatory agencies like the FDA and EMA enforce strict guidelines for biologics' stability. Lastly, the expansion of bioprocessing and industrial biotechnology requires robust proteins with enhanced stability for consistent performance, stimulating continued investment in protein stability analysis tools and technologies. These factors collectively underscore a market where precision in protein stability is essential for product success, safety, and market competitiveness.

Scope of the Study

The report analyzes the Protein Stability Analysis market, presented in terms of market value (US$ Thousand). The analysis covers the key segments and geographic regions outlined below.

Segments

Product (Reagents & Assay Kits, Instruments, Consumable & Accessories, Software); Technique (Chromatography, Spectroscopy, Surface Plasma Resonance Imaging (SPRI), Differential Scanning Calorimetry (DSC), Differential Scanning Fluorimetry (DSF), Other Techniques); End-Use (Pharma & Biotech Companies, Contract Research Organizations, Academic & Research Institutes)

Geographic Regions/Countries

World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; Spain; Russia; and Rest of Europe); Asia-Pacific (Australia; India; South Korea; and Rest of Asia-Pacific); Latin America (Argentina; Brazil; Mexico; and Rest of Latin America); Middle East (Iran; Israel; Saudi Arabia; United Arab Emirates; and Rest of Middle East); and Africa.

Key Insights:

  • Market Growth: Understand the significant growth trajectory of the Reagents & Assay Kits segment, which is expected to reach US$2.1 Billion by 2030 with a CAGR of a 9.5%. The Instruments segment is also set to grow at 7.0% CAGR over the analysis period.
  • Regional Analysis: Gain insights into the U.S. market, estimated at $584.7 Million in 2023, and China, forecasted to grow at an impressive 13.1% CAGR to reach $1.1 Billion by 2030. Discover growth trends in other key regions, including Japan, Canada, Germany, and the Asia-Pacific.

Why You Should Buy This Report:

  • Detailed Market Analysis: Access a thorough analysis of the Global Protein Stability Analysis Market, covering all major geographic regions and market segments.
  • Competitive Insights: Get an overview of the competitive landscape, including the market presence of major players across different geographies.
  • Future Trends and Drivers: Understand the key trends and drivers shaping the future of the Global Protein Stability Analysis Market.
  • Actionable Insights: Benefit from actionable insights that can help you identify new revenue opportunities and make strategic business decisions.

Key Questions Answered:

  • How is the Global Protein Stability Analysis Market expected to evolve by 2030?
  • What are the main drivers and restraints affecting the market?
  • Which market segments will grow the most over the forecast period?
  • How will market shares for different regions and segments change by 2030?
  • Who are the leading players in the market, and what are their prospects?

Report Features:

  • Comprehensive Market Data: Independent analysis of annual sales and market forecasts in US$ Million from 2023 to 2030.
  • In-Depth Regional Analysis: Detailed insights into key markets, including the U.S., China, Japan, Canada, Europe, Asia-Pacific, Latin America, Middle East, and Africa.
  • Company Profiles: Coverage of major players in the Global Protein Stability Analysis Market such as Agilent Technologies, Inc., Enzo Biochem, Inc., General Electric, Horiba, Ltd, Perkinelmer, Inc. and more.
  • Complimentary Updates: Receive free report updates for one year to keep you informed of the latest market developments.

Some of the 32 companies featured in this Global Protein Stability Analysis Market report include:

  • Agilent Technologies, Inc.
  • Enzo Biochem, Inc.
  • General Electric
  • Horiba, Ltd
  • Perkinelmer, Inc.
  • Setaram Instrumentation
  • Shimadzu Corporation
  • Spectris PLC
  • Thermo Fisher Scientific
  • Unchained Labs
  • Waters Corporation

Table of Contents

I. METHODOLOGYII. EXECUTIVE SUMMARY
1. MARKET OVERVIEW
  • Influencer Market Insights
  • World Market Trajectories
  • Global Economic Update
  • Protein Stability Analysis - Global Key Competitors Percentage Market Share in 2024 (E)
  • Competitive Market Presence - Strong/Active/Niche/Trivial for Players Worldwide in 2024 (E)
2. FOCUS ON SELECT PLAYERS
3. MARKET TRENDS & DRIVERS
  • Rising Demand for Biopharmaceuticals and Biosimilars Drives Growth in Protein Stability Analysis for Quality Assurance
  • Increasing Complexity of Biologic Drugs Spurs Adoption of Advanced Protein Stability Analysis Techniques in Drug Development
  • Technological Advancements in Analytical Tools Strengthen the Precision and Efficiency of Protein Stability Analysis
  • Growing Focus on Drug Safety and Efficacy Standards Expands Market Demand for Robust Protein Stability Testing
  • Development of Personalized Medicine Accelerates Demand for Protein Stability Analysis in Targeted Therapeutic Applications
  • Expansion of Protein-Based Therapeutics in Immunotherapy and Oncology Spurs Need for Enhanced Stability Analysis Techniques
  • Integration of Artificial Intelligence in Protein Stability Analysis Enhances Predictive Accuracy and Speeds Drug Development Timelines
  • Increased Research in Protein Engineering and Protein-Protein Interactions Generates Demand for Precise Stability Analysis Tools
  • Rising Interest in Structural Biology Expands Applications for Protein Stability Analysis in Basic and Applied Research
  • Advancements in Mass Spectrometry and Differential Scanning Calorimetry Propel Growth of High-Throughput Stability Testing
  • Expanding Applications in Agriculture and Food Industries Drive Demand for Protein Stability Analysis in Crop and Nutritional Science
4. GLOBAL MARKET PERSPECTIVE
  • Table 1: World Recent Past, Current & Future Analysis for Protein Stability Analysis by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 2: World Historic Review for Protein Stability Analysis by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 3: World 16-Year Perspective for Protein Stability Analysis by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets for Years 2014, 2024 & 2030
  • Table 4: World Recent Past, Current & Future Analysis for Reagents & Assay Kits by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 5: World Historic Review for Reagents & Assay Kits by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 6: World 16-Year Perspective for Reagents & Assay Kits by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 7: World Recent Past, Current & Future Analysis for Instruments by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 8: World Historic Review for Instruments by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 9: World 16-Year Perspective for Instruments by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 10: World Recent Past, Current & Future Analysis for Consumable & Accessories by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 11: World Historic Review for Consumable & Accessories by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 12: World 16-Year Perspective for Consumable & Accessories by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 13: World Recent Past, Current & Future Analysis for Software by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 14: World Historic Review for Software by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 15: World 16-Year Perspective for Software by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 16: World Recent Past, Current & Future Analysis for Other Techniques by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 17: World Historic Review for Other Techniques by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 18: World 16-Year Perspective for Other Techniques by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 19: World Recent Past, Current & Future Analysis for Chromatography by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 20: World Historic Review for Chromatography by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 21: World 16-Year Perspective for Chromatography by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 22: World Recent Past, Current & Future Analysis for Spectroscopy by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 23: World Historic Review for Spectroscopy by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 24: World 16-Year Perspective for Spectroscopy by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 25: World Recent Past, Current & Future Analysis for Surface Plasma Resonance Imaging (SPRI) by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 26: World Historic Review for Surface Plasma Resonance Imaging (SPRI) by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 27: World 16-Year Perspective for Surface Plasma Resonance Imaging (SPRI) by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 28: World Recent Past, Current & Future Analysis for Differential Scanning Calorimetry (DSC) by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 29: World Historic Review for Differential Scanning Calorimetry (DSC) by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 30: World 16-Year Perspective for Differential Scanning Calorimetry (DSC) by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 31: World Recent Past, Current & Future Analysis for Differential Scanning Fluorimetry (DSF) by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 32: World Historic Review for Differential Scanning Fluorimetry (DSF) by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 33: World 16-Year Perspective for Differential Scanning Fluorimetry (DSF) by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 34: World Recent Past, Current & Future Analysis for Pharma & Biotech Companies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 35: World Historic Review for Pharma & Biotech Companies by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 36: World 16-Year Perspective for Pharma & Biotech Companies by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 37: World Recent Past, Current & Future Analysis for Contract Research Organizations by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 38: World Historic Review for Contract Research Organizations by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 39: World 16-Year Perspective for Contract Research Organizations by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 40: World Recent Past, Current & Future Analysis for Academic & Research Institutes by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2023 through 2030 and % CAGR
  • Table 41: World Historic Review for Academic & Research Institutes by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa Markets - Independent Analysis of Annual Sales in US$ Thousand for Years 2014 through 2022 and % CAGR
  • Table 42: World 16-Year Perspective for Academic & Research Institutes by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific, Latin America, Middle East and Africa for Years 2014, 2024 & 2030
  • Table 43: World Protein Stability Analysis Market Analysis of Annual Sales in US$ Thousand for Years 2014 through 2030
III. MARKET ANALYSIS
UNITED STATES
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United States for 2024 (E)
CANADA
JAPAN
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Japan for 2024 (E)
CHINA
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in China for 2024 (E)
EUROPE
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Europe for 2024 (E)
FRANCE
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in France for 2024 (E)
GERMANY
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Germany for 2024 (E)
ITALY
UNITED KINGDOM
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in the United Kingdom for 2024 (E)
SPAINRUSSIAREST OF EUROPE
ASIA-PACIFIC
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Asia-Pacific for 2024 (E)
AUSTRALIA
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Australia for 2024 (E)
INDIA
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in India for 2024 (E)
SOUTH KOREAREST OF ASIA-PACIFIC
LATIN AMERICA
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Latin America for 2024 (E)
ARGENTINABRAZILMEXICOREST OF LATIN AMERICA
MIDDLE EAST
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Middle East for 2024 (E)
IRANISRAELSAUDI ARABIAUNITED ARAB EMIRATESREST OF MIDDLE EAST
AFRICA
  • Protein Stability Analysis Market Presence - Strong/Active/Niche/Trivial - Key Competitors in Africa for 2024 (E)
IV. COMPETITION

Companies Mentioned

  • Agilent Technologies, Inc.
  • Enzo Biochem, Inc.
  • General Electric
  • Horiba, Ltd
  • Perkinelmer, Inc.
  • Setaram Instrumentation
  • Shimadzu Corporation
  • Spectris PLC
  • Thermo Fisher Scientific
  • Unchained Labs
  • Waters Corporation

Table Information