Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission.
Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.
To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients.
A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.
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Table of Contents
Part I: Basis of the Disease
Section A: Genetics and epigenetics
1. Major histocompatibility complex and SLE
2. Lupus Susceptibility genes
3. Epigenetics in systemic lupus erythematosus and the integration of molecular pathways
Section B: Immunopathogenesis
4. Autoantigens, antigenic mimicry, and immune complexes
5. B-cell Biology, tolerance and autoantibodies
6. T-Cell Biology, tolerance and regulation
7. Polymorphonuclear cells
8. Metabolic and mitochondrial dysfunction in SLE
9. Immunopathogenesis: the role of mucosal and skin microbiota in SLE
Section C: Disease effectors and modifiers
10. Complement and SLE
11. Interferons and cytokines in SLE pathogenesis and therapy
12. Innate immunity in SLE pathogenesis
13. Sex bias in SLE
Section D: Tissue injury-the Biology
14. Mechanisms of tissue injury in lupus nephritis
15. The skin
16. The brain in SLE: mechanisms and detection of injury and therapeutic strategies
17. The role of infections in SLE pathogenesis
18. Tissue injurydthe biology: SLE-associated vascular disease and antiphospholipid syndrome
Part II: Clinical presentation of disease
Section A: Clinical presentation
19. Epidemiology of SLE and related diseases: incidence, prevalence, and mortality
20. The clinical presentation of systemic lupus erythematosus and laboratory diagnosis
21. Passively acquired lupus in the fetus and neonate
22. Systemic lupus erythematosus in children
23. Environmental and drug-induced lupus
24. Reproductive health
25. Monitoring disease activity
26. Overlap syndromes
Section B: Specific organ involvement and clinical presentation
27. Nervous system
28. Skin
29. Kidney disease
30. Cardiovascular disease in lupus
31. Pulmonary manifestations of systemic lupus erythematosus
32. GI hepatic and nonhepatic diseases
33. Musculoskeletal system: articular disease, myositis, and bone metabolism
34. Clinical presentation of antiphospholipid syndrome
35. Hematology: cytopenias
36. Malignancy risk and screening
Section C: Treatment of systemic llupus erythematosus
37. Antimalarial drugs (and lupus)
38. Glucocorticoids
39. Immunosuppressive therapy in SLE
40. Pipeline therapies and future drug development
41. Challenges of systemic lupus clinical trials
