Strategies and Tactics in Organic Synthesis, Volume 15, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project.
Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world.
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Table of Contents
1. Amaryllidaceae isocarbostyril alkaloids2. Enzymatic dihydroxylation of aromatic compounds: Nature's unique reaction and its impact on the synthesis of natural products
3. Intermolecular oxidopyrylium [5+2] cycloaddition chemistry and its application toward the synthesis and study of highly oxygenated troponoids
4. Aryne-mediated construction of fluorene skeletons and its applications to total synthesis of selaginpulvilins
5. Cycloisomerizations across three states: the total synthesis of gelsenicine
6. Tetrapetalones ruminations, trials and tribulations
7. The synthesis of herqulines B and C
8. First total synthesis of the dimeric naphthoquinonopyranolactone natural product (-)-crisamicin A. how procrastination may be of help in binaphthyl synthesis
9. Strategies and discoveries leading to the synthesis of trichoaurantianolide natural products
10. 4-exo-dig cyclocarbopalladation, discovery and application in the synthesis of complex polycyclic molecules
Authors
Michael Harmata University of Missouri, MO, USA.Professor Michael Harmata graduated from the University of Illinois-Chicago with honors and highest distinction in chemistry.
In 1980, he began graduate studies in chemistry at the University of Illinois-Champaign/Urbana where he was awarded a University Teaching Fellowship. He worked with Professor Scott E. Denmark on the invention of the carbanion-accelerated Claisen rearrangement. In his second year of study, he was awarded an Eastman Kodak Research Fellowship.
Upon graduation in 1985, he was awarded an NIH postdoctoral fellowship which he used to study with Professor Paul A. Wender at Stanford University, where he worked on the synthesis of the neocarzinostatin chromophore.
In 1986, Prof. Harmata began his independent career at the University of Missouri-Columbia. He became an Associate Professor in 1992 and a full professor in 1998. In 2000, he was named the Norman Rabjohn Distinguished Professor of Chemistry in recognition of his achievements in research and teaching. In 1998, he received a research fellowship from the Alexander von Humboldt Foundation and stayed for a year at the University of G?ttingen where he was affiliated with the groups of Professors Reinhard Br?ckner and Lutz. F. Tietze. In 2000, he served as chair of the Gordon conference on Organic Reactions and Processes. In 2010, he was named the first Justus Liebig Professor of Chemistry at the Justus Liebig ?niversit?t in Giessen, Germany. In 2011, he was a JSPS fellow. He has been a visiting professor in Giessen and Strasbourg and has delivered over 180 invited lectures in the United States and Europe. He is a member of the American Chemical Society, Gesellschaft Deutscher Chemiker, International Society of Heterocyclic Chemistry, and the Alexander von Humboldt Association of America.
