Researchers have tried various effective treatments that prevent the progressive neurodegeneration of neurons within the brain. Parkinson’s disease (PD), Alzheimer’s disease (AD), and Multiple sclerosis (MS) are some of the most common neurodegenerative diseases (NDDs).
Recent Advances in the Treatment of Neurodegenerative Disorders provide interesting updates on treatments of these neurological disorders. Ten chapters have been contributed by experts in pharmacology and give a unique perspective to the reader on special topics in this area, including the treatment of the neurodegenerative treatment of neurodegenerative disease through Ayurveda and phytochemicals, the therapeutic role of vitamins in Parkinson’s disease, mushrooms in NDD treatment, MS treatment, ALS treatment and the use of nanoparticles and nano formulations in NDD treatment.
This is an informative reference for pharmacologists, medicinal chemists and healthcare professionals (general practitioners and neurologists) seeking updates in the treatment of some common neurodegenerative disorders.
Table of Contents
Chapter 1 An Introduction to Neurodegenerative Diseases and Its Treatment
- Introduction
- Ayurveda in Neurodegenerative Diseases (NDS)
- Vitamins in Neurodegenerative Diseases (NDS)
- Gut-Brain Axis and Associated Pro and Pre-Biotics Therapy for NDS 3
- Nanoparticles and Nanoformulation Based Therapy for Different NDS
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 2 Recent Advancement in the Treatment of Neurodegenerative Diseases by Ayurveda
- Introduction
- Overview of Neurodegenerative Diseases (NDDS)
- The Preamble of Common Neurodegenerative Diseases
- Alzheimer's Disease (AD)
- Parkinson's Disease (PD)
- Huntington's Disease (HD)
- Pathogenesis of Neurodegenerative Diseases
- Pathway of Development of Neurodegenerative Diseases
- Common Signs & Symptoms of Neurodegenerative Diseases
- Diagnosis of Neurodegenerative Diseases
- A Range of Treatment for the Neurodegenerative Diseases
- The Modern System of Medicine
- Medical Management
- Surgical Management
- Emerging Management
- Ayush or Indian System of Medicine
- Recent Advancement in the Ayurvedic Management of Neurodegenerative Diseases
- Ayurvedic/Herbal Medicinal Plants
- Different Actions of an Extract Derived from Ayurvedic Medicinal Plants
- Herbo-Mineral Drugs
- Panchkarma (Bio-Purification Procedures)
- Overview of Panchkarma Therapy
- Studies Conducted in Different Panchkarma Procedures
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 3 Role of Phytochemicals in Neurodegenerative Disorders
- Introduction
- Pathogenesis of Neurodegeneration
- Role of Phytochemicals in Neurodegeneration
- Neruroprotecting Phytochemicals
- Epigallocatechin-3-Gallate
- Berberine
- Curcumin
- Resveratrol
- Quercetin
- Fisetin
- Ginsenosides
- Sulforaphane (Sfn)
- Genistein
- Allium and Allicin
- Icariin
- Morin
- Baicalein
- Conclusions
- Future Suggestion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 4 Therapeutic Potential of Vitamins in Parkinson's Disease
- Introduction
- Role of Oxidative Stress in the Pathogenesis of Pd
- Theatrical Role of Neuroinflammation in the Pathogenesis of Pd
- Neuroprotective Roles of Vitamins in the Treatment of Parkinsonism
- Neuroprotective Role of Vitamin B in Pd
- Usability of Vitamin C in Pd Treatment
- Role of Vitamin E in the Treatment of Pd
- Role of Vitamin D as a Neuroprotectant in the Pd Treatment
- Conclusion and Future Directions
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 5 Potential of Gut Microbiome in the Diagnosis and Treatment of Alzheimer's and Parkinson's Disease
- Introduction
- Alzheimer's Disease: Pathomechanism, Prevalence, Symptoms, and Treatment
- Prevalence of AD
- Symptoms of AD
- Causes of AD
- Treatment Strategies for AD
- Acetylcholine Esterase (ACHE)
- Β Secretase
- ϒ Secretase
- Aβ Vaccination
- Amyloid Anti-Aggregation Therapies
- Anti-Inflammatory Drugs
- Cholesterol-Lowering Drugs
- Parkinson's Disease: Pathomechanism, Prevalence, Symptoms, And
- Treatment
- Prevalence of Pd
- Symptoms of Pd
- Treatment Strategies for Pd
- Dopamine Replacement Therapy (DRT)
- L-Dopa: Promising DRT for PD
- Anti-Inflammatory Agents and Protein Anti-Aggregants
- Role of Gut Microbiome in Metabolism and Health
- Role of Prebiotics in Gut Microflora Balance
- Gut Microbiome and Neurodegenerative Disease
- Gut and Alzheimer's Disease
- Therapeutic Role of Probiotics in AD
- Prebiotics for AD
- Gut Microbiome and Parkinson's Disease
- Probiotics and Prebiotics for Pd
- Mediterranean Diet
- Ketogenic Diet and Fasting
- Polyphenols
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 6 Therapeutic Efficacy of Mushroom in Neurodegenerative Diseases
- Introduction
- Neuroprotective Effects of Mushrooms Against
- Neurodegenerative Disease
- Advantageous Effects of Mushrooms Against NDS
- Role of Mushrooms in Alzheimer's Disease (Ad)
- Mushrooms Having Beneficial Effects Against Parkinson's Disease (PD)
- Conclusions
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 7 Advances in Experimental Animal Models Provide Insights Into Different Etiology and Mechanism of Multiple Sclerosis to Design Therapeutics
- Introduction
- Classification of MS
- Etiology of MS
- Clinical Symptoms and Diagnosis
- Present Therapeutics and Limitations
- Experimental Animal Models to Understand the Mechanisms of Ms 143
- Experimental Autoimmune Encephalomyelitis (Eae)
- Experimental Viral-Induced Model of Ms
- TMEV Model
- MHV Model
- MHV Mediated Immune Responses
- Recombinant Demyelinating (Dm) and Non-Demyelinating (NDM) MHV Strains
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 8 Novel Therapeutic Targets in Amyotrophic Lateral Sclerosis
- Introduction
- History
- Epidemiology
- Sign and Symptoms
- Clinical Characteristics
- Genetics
- Mutation
- Als Pathogenic Pathways as Therapeutic Targets
- Targeting Oxidative Stress
- Targeting Glutamate Transport
- Targeting Protein Aggregation
- Targeting Mitochondrial Dysfunction
- Targeting Apoptosis
- Targeting Neuroinflammation
- Targeting Glial Cells (Microglia and Astrocytes)
- Targeting Dysregulated Rna Process
- Targeting Neuromuscular Junction
- Targeting Gene
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 9 Impact of Nano-Formulations of Natural CompouNDS in The Management of Neuro Degenerative Diseases
- Introduction
- Neuroprotective Potential of Natural Products
- Approaches for Cns Targeted Natural CompouNDS Delivery
- Nano-Based Delivery Systems for Neurodegenerative Disorders
- Lipidic Nanomaterials
- Liposomes
- Solid Lipid Nanoparticles and Nanostructured Lipid Carrier Systems
- Carbon Nanomaterials
- Carbon Nanotubes
- NanodiamoNDS
- Polymeric Systems
- Dendrimers
- Metal-Organic Frameworks (MOFS)
- Semiconducting Nanoparticles and Quantum Dots
- Phospholipid Complexes
- Methods of Nanoformulations Preparation
- Emulsion-Solvent Evaporation Method
- Solvent Diffusion Method
- Salting Out Method
- Supercritical Fluid Technique
- Polymerization Technique
- Natural CompouNDS Nano-Delivery in Neuro Degenerative Diseases 191
- Alzheimer's Disease
- Huntington's Disease
- Parkinson's Disease
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 10 Recent Advancement in the Nanoparticles Mediated Therapeutics of Parkinson's Disease
- Introduction
- Nanoparticles Based Therapy for Parkinson's Disease
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Subject Index
Author
- Sachchida Nand Rai
