+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

Diagnostic Pathology : Hepatobiliary and Pancreas. Edition No. 3

  • Book

  • September 2021
  • Elsevier Health Science
  • ID: 5349920
This expert volume in the�Diagnostic Pathology�series is an�excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of neoplastic and nonneoplastic diseases of the digestive tract and accessory organs such as the pancreas and liver, it incorporates the most recent clinical, pathological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use,�Diagnostic Pathology: Hepatobiliary and Pancreas�is�a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
  • Analyzes�hundreds of diagnoses, each of which include critical diagnostic information such as definitions, epidemiology, clinical presentation, macro- and microscopic features, differential diagnoses, and pathologic interpretation pearls.�

  • Features�thorough updates throughout, including novel immunohistochemical markers and other ancillary techniques (such as BAP1, INSM1, Rb, albumin in situ hybridization) that play an increasingly critical role in improving diagnoses�

  • Addresses�recent advances in molecular pathology-new diagnostic, immunohistochemical, molecular, and genetic techniques used for diagnosis, as well as new details about the genesis and activity of tumors in the liver, pancreas, and biliary systems�

  • Includes details from the 2019 WHO Classification of Tumors of the Digestive System regarding�important changes to diagnostic techniques, identification of new variants of cancers, and immunohistochemical markers and ancillary techniques that improve diagnosis and treatment options�

  • Reflects�recent WHO updates�and�updates from the AJCC's 8th Edition Cancer Staging Manual�such as new terminology, new grading of neuroendocrine tumors and neuroendocrine carcinomas, and characteristic molecular alterations in hepatocellular adenoma, cholangiocarcinoma, and other tumors�

  • Uses a�templated page layout, bulleted text, and a generous number of�high-quality images�to help practicing and in-training pathologists reach a confident diagnosis�

  • Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Table of Contents

SECTION 1: LIVER

INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERS

4�Glycogen Storage Disease, Hepatic Joseph Misdraji, MD, Lisa Yerian, MD, and Grace E. Kim, MD 10�Tyrosinemia Joseph Misdraji, MD 12�Niemann-Pick Disease Joseph Misdraji, MD 14�Gaucher Disease Joseph Misdraji, MD 16�Neonatal Hemochromatosis Joseph Misdraji, MD 18�Porphyrin Metabolism Disorders Maria Westerhoff, MD and Joseph Misdraji, MD 24�Dubin-Johnson Syndrome Joseph Misdraji, MD and Sanjay Kakar, MD 26�Gilbert Disease Joseph Misdraji, MD and Sanjay Kakar, MD 28�Progressive Familial Intrahepatic Cholestasis Joseph Misdraji, MD 36�Cystic Fibrosis, Hepatic Joseph Misdraji, MD 40�Hereditary Hemochromatosis Joseph Misdraji, MD and Laura W. Lamps, MD 44�Wilson Disease Joseph Misdraji, MD and Laura W. Lamps, MD 50�Alpha-1-Antitrypsin Deficiency Nicole C. Panarelli, MD, Kari D. Caradine, MD, and Laura W. Lamps, MD 54�Congenital Hepatic Fibrosis Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD 56�Polycystic Liver Disease Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD 58�Caroli Disease Romil Saxena, MBBS, MD, FRCPath (UK) � INFECTIOUS DISORDERS� 60�Overview of Hepatitis Nicole C. Panarelli, MD and Laura W. Lamps, MD 66�Acute Viral Hepatitis Nicole C. Panarelli, MD and Lisa Yerian, MD 70�Hepatitis B Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD 74�Hepatitis C Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD 78�Hepatitis E Maria Westerhoff, MD 82�Epstein-Barr Virus Laura W. Lamps, MD, Maria Westerhoff, MD, and Hanlin L. Wang, MD, PhD 86�Cytomegalovirus Laura W. Lamps, MD 88�Herpes Simplex Virus Sanjay Kakar, MD 90�Adenovirus Maria Westerhoff, MD and Hanlin L. Wang, MD, PhD 92�Pyogenic Abscess Laura W. Lamps, MD 96�Sepsis in Liver Laura W. Lamps, MD 98�Mycobacterium tuberculosis Laura W. Lamps, MD 102�Atypical Mycobacteria Laura W. Lamps, MD 106�Cat-Scratch Disease Laura W. Lamps, MD 108�Candidiasis Laura W. Lamps, MD 110�Histoplasmosis Joseph Misdraji, MD and Laura W. Lamps, MD 114�Cryptococcosis Laura W. Lamps, MD 116�Amebiasis Laura W. Lamps, MD 120�Schistosomiasis Laura W. Lamps, MD 122�Echinococcosis Laura W. Lamps, MD

CHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERS 124�Autoimmune Hepatitis Nicole C. Panarelli, MD and Lisa Yerian, MD 130�Primary Biliary Cholangitis Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD 136�Primary Sclerosing Cholangitis Hanlin L. Wang, MD, PhD 142�Ischemic Cholangitis Maria Westerhoff, MD and Lisa Yerian, MD 144�Large Bile Duct Obstruction Maria Westerhoff, MD and Laura W. Lamps, MD 148�Idiopathic Adulthood Ductopenia Hanlin L. Wang, MD, PhD PEDIATRIC CHOLESTATIC DISORDERS� 150�Biliary Atresia Romil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD 154�Idiopathic Neonatal Hepatitis Romil Saxena, MBBS, MD, FRCPath (UK), Grace E. Kim, MD, and Matthew M. Yeh, MD, PhD 156�Syndromic Paucity of Intrahepatic Bile Ducts (Alagille Syndrome) Joseph Misdraji, MD, Romil Saxena, MBBS, MD, FRCPath (UK), and Matthew M. Yeh, MD, PhD 160�Nonsyndromic Paucity of Intrahepatic Bile Ducts Romil Saxena, MBBS, MD, FRCPath (UK), Joseph Misdraji, MD, and Matthew M. Yeh, MD, PhD � DRUG/TOXIN-RELATED HEPATITIS� 164�Drug-Related Acute Hepatitis Sanjay Kakar, MD 170�Drug-Induced Acute Hepatic Failure Sanjay Kakar, MD 174�Drug-Induced Cholestatic Liver Injury Sanjay Kakar, MD 176�Drug-Related Granulomatous Hepatitis Laura W. Lamps, MD 180�Drug-Related Steatohepatitis/Phospholipidosis Laura W. Lamps, MD 184�Reye Syndrome Romil Saxena, MBBS, MD, FRCPath (UK) and Lisa Yerian, MD 186�Drug-Related Cholangitis/Ductopenia Maria Westerhoff, MD 192�Hepatic Stellate Cell Hyperplasia Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD � FATTY LIVER DISEASES� 194�Alcoholic Liver Disease Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD 200�Nonalcoholic Steatohepatitis Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD 208�Glycogenic Hepatopathy Maria Westerhoff, MD and Lisa Yerian, MD 210�Fatty Liver of Pregnancy Nicole C. Panarelli, MD and Lisa Yerian, MD

VASCULAR DISORDERS�

212�Portal Venous Obstruction Hanlin L. Wang, MD, PhD 214�Hepatoportal Sclerosis Hanlin L. Wang, MD, PhD 216�Hepatic Venous Outflow Obstruction Sanjay Kakar, MD 220�Venoocclusive Disease Sanjay Kakar, MD 222 �Amyloidosis Sanjay Kakar, MD 224�Ischemia �Rondell Graham, MBBS and Lisa Yerian, MD 226�Nodular Regenerative Hyperplasia Sanjay Kakar, MD � TRANSPLANTATION PATHOLOGY� 228�Ischemia Reperfusion Injury Romil Saxena, MBBS, MD, FRCPath (UK) and Hanlin L. Wang, MD, PhD 230�Antibody-Mediated Rejection Hanlin L. Wang, MD, PhD and Romil Saxena, MBBS, MD, FRCPath (UK) 232�T-Cell-Mediated Rejection (Acute Cellular Rejection) Romil Saxena, MBBS, MD, FRCPath (UK) 236�Chronic Rejection Romil Saxena, MBBS, MD, FRCPath (UK) and Matthew M. Yeh, MD, PhD 238�Central Perivenulitis/Parenchymal Rejection Rondell Graham, MBBS 240�Hepatic Artery Thrombosis Rondell Graham, MBBS and Lisa Yerian, MD 242�Graft-vs.-Host Disease Rondell Graham, MBBS and Lisa Yerian, MD � TUMORS OF THE LIVER� 244�Hepatic Adenoma Sanjay Kakar, MD and Matthew M. Yeh, MD, PhD 252�Focal Nodular Hyperplasia Sanjay Kakar, MD 256�Regenerative and Dysplastic Nodules Sanjay Kakar, MD 262�Hepatocellular Carcinoma and Variants Sanjay Kakar, MD 274�Fibrolamellar Carcinoma Rondell Graham, MBBS 278�Combined Hepatocellular-Cholangiocarcinoma Maria Westerhoff, MD 282�Hepatoblastoma Rondell Graham, MBBS 286�Bile Duct Adenoma Rondell Graham, MBBS and Sanjay Kakar, MD 288�von Meyenburg Complex (Biliary Microhamartoma) Sanjay Kakar, MD, Laura W. Lamps, MD, and Rondell Graham, MBBS 290�Mucinous Cystic Neoplasm, Liver Maria Westerhoff, MD and Matthew M. Yeh, MD, PhD 294�Intrahepatic Cholangiocarcinoma Rondell Graham, MBBS and Sanjay Kakar, MD 298�Intrahepatic Cholangiocarcinoma Histologic Subtypes Rondell Graham, MBBS 302�Intraductal Papillary Neoplasm Rondell Graham, MBBS 304�Hemangioma Rondell Graham, MBBS 306�Angiomyolipoma Rondell Graham, MBBS and Lisa Yerian, MD 310�Hepatic Small Vessel Neoplasm/Anastamosing Hemangioma Maria Westerhoff, MD 314�Epithelioid Hemangioendothelioma Sanjay Kakar, MD 316�Infantile Hemangioma Sanjay Kakar, MD 318�Angiosarcoma Sanjay Kakar, MD 320�Mesenchymal Hamartoma Nicole C. Panarelli, MD, Hanlin L. Wang, MD, PhD, and Sanjay Kakar, MD 322�Embryonal Sarcoma Nicole C. Panarelli, MD 324�Inflammatory Pseudotumor Joseph Misdraji, MD 330�Segmental Atrophy (Nodular Elastosis) Joseph Misdraji, MD 332�Hepatectomy Specimen Handling Rondell Graham, MBBS and Laura W. Lamps, MD � MISCELLANEOUS HEPATIC DISORDERS� 334�Langerhans Cell Histiocytosis Maria Westerhoff, MD and Hanlin L. Wang, MD, PhD 338�Hemophagocytic Syndromes Hanlin L. Wang, MD, PhD

� DEVELOPMENTAL/CONGENITAL� 342�Congenital Pancreatic Cyst Hanlin L. Wang, MD, PhD 344�Cystic Fibrosis, Pancreas Hanlin L. Wang, MD, PhD 346�Nesidioblastosis Hanlin L. Wang, MD, PhD 348�Choledochal Cyst Romil Saxena, MBBS, MD, FRCPath (UK) and Laura W. Lamps, MD 350�Cholelithiasis Laura W. Lamps, MD 352�Acute Cholecystitis Sanjay Kakar, MD 354�Chronic Cholecystitis Sanjay Kakar, MD 356�Xanthogranulomatous Cholecystitis Laura W. Lamps, MD 358�Eosinophilic Cholecystitis Laura W. Lamps, MD 360�Polyarteritis Nodosa and Other Vasculitides Nicole C. Panarelli, MD 362�Parasitic Infection Laura W. Lamps, MD

NONNEOPLASTIC AND INFLAMMATORY DISORDERS OF THE PANCREAS

366�Acute Pancreatitis Grace E. Kim, MD and Alyssa M. Krasinskas, MD 368�Chronic Pancreatitis Alyssa M. Krasinskas, MD and Lisa Yerian, MD 372�Autoimmune Pancreatitis Alyssa M. Krasinskas, MD and Lisa Yerian, MD 376�Groove Pancreatitis Alyssa M. Krasinskas, MD, Lisa Yerian, MD, and Vikram Deshpande, MD 378�Infectious Pancreatitis Laura W. Lamps, MD 380�Pseudocysts Alyssa M. Krasinskas, MD, Vikram Deshpande, MD, and Lisa Yerian, MD 382�Diabetes Mellitus Laura W. Lamps, MD 384�Lymphoepithelial Cyst of the Pancreas Alyssa M. Krasinskas, MD and Lisa Yerian, MD

TUMORS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREE 386�Noninvasive Epithelial Polypoid Lesions

390�Nicole C. Panarelli, MD and Sanjay Kakar, MD Carcinoma of Gallbladder

396�Nicole C. Panarelli, MD and Laura W. Lamps, MD Carcinoma of Extrahepatic Bile Ducts

402�Rondell Graham, MBBS and Laura W. Lamps, MD Squamous/Adenosquamous Carcinoma, Gallbladder

404�Hanlin L. Wang, MD, PhD Neuroendocrine Neoplasms of Gallbladder

408�Hanlin L. Wang, MD, PhD Granular Cell Tumor

410�Nicole C. Panarelli, MD Embryonal Rhabdomyosarcoma

412�Hanlin L. Wang, MD, PhD Adenomyoma

414�Nicole C. Panarelli, MD and Lisa Yerian, MD Nonneoplastic Polypoid Gallbladder Lesions �Nicole C. Panarelli, MD and Laura W. Lamps, MD � TUMORS OF THE PANCREAS� 418�Pancreatic Intraepithelial Neoplasia Alyssa M. Krasinskas, MD and Sanjay Kakar, MD 420�Ductal Adenocarcinoma, Including Variants Alyssa M. Krasinskas, MD, Sanjay Kakar, MD, and Mari Mino-Kenudson, MD 424�Undifferentiated Carcinoma Wei Zheng, MD, Sanjay Kakar, MD, and Alyssa M. Krasinskas, MD 426�Adenosquamous Carcinoma, Pancreas Alyssa M. Krasinskas, MD 428�Serous Cystadenoma Sanjay Kakar, MD and Grace E. Kim, MD 432�Acinar Cell Cystadenoma Maria Westerhoff, MD �

436�Simple Mucinous Cyst Maria Westerhoff, MD 438�Mucinous Cystic Neoplasm, Pancreas Maria Westerhoff, MD 442�Intraductal Papillary Mucinous Neoplasm Mari Mino-Kenudson, MD, Zaid Mahdi, MD, and Alyssa M. Krasinskas, MD 448�Intraductal Oncocytic Papillary Neoplasm Alyssa M. Krasinskas, MD and Mari Mino-Kenudson, MD 450�Intraductal Tubulopapillary Neoplasm Alyssa M. Krasinskas, MD and Mari Mino-Kenudson, MD 452�Acinar Cell Carcinoma Laura W. Lamps, MD, Wei Zheng, MD, and Alyssa M. Krasinskas, MD 456�Pancreatoblastoma Alyssa M. Krasinskas, MD, Laura W. Lamps, MD, and Matthew M. Yeh, MD, PhD 458�Dermoid Cyst Zaid Mahdi, MD, Vikram Deshpande, MD, and Alyssa M. Krasinskas, MD 460�Poorly Differentiated Neuroendocrine Carcinoma, Pancreas Sanjay Kakar, MD 464�Well-Differentiated Neuroendocrine Tumor, Pancreas Sanjay Kakar, MD 470�Solid-Pseudopapillary Tumors Sanjay Kakar, MD � TUMORS OF THE AMPULLA� 474�Ampullary Adenoma Hanlin L. Wang, MD, PhD 476�Ampullary Adenocarcinoma and Variants Hanlin L. Wang, MD, PhD 480�Well-Differentiated Neuroendocrine Tumor, Ampulla Hanlin L. Wang, MD, PhD 482�Gangliocytic Paraganglioma Maria Westerhoff, MD � SPECIMEN HANDLING, WHIPPLE� 484�Specimen Handling, Whipple Alyssa M. Krasinskas, MD and Laura W. Lamps, MD

Authors

Laura W. Lamps Professor and Vice-Chair for Academic Affairs
, Department of Pathology,
University of Arkansas for Medical Sciences,
Little Rock, Arkansas. Maria Westerhoff Associate Professor, Department of Pathology, University of Michigan. Sanjay Kakar