Tissue Engineering: Current Status and Challenges bridges the gap between biomedical scientists and clinical practitioners. The work reviews the history of tissue engineering, covers the basics required for the beginner, and inspires those in the field toward future research and application emerging in this fast-moving field. Written by global experts in the field for those studying and researching tissue engineering, the book reviews regenerative technologies, stem cell research and regeneration of organs. It then moves to soft tissue engineering (heart, vascular, muscle and 3D scaffolding and printing), hard tissue engineering (bone, dental myocardial and musculoskeletal) and translational avenues in the field.
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Table of Contents
1. Preface
2. Introductory Chapter
Section 1: Regenerative Technologies
3. Overview of current technologies for TE and RM
4. Myocardial tissue engineering: Fundamentals and advanced technologies
5. Oro-dental regeneration
6. Tissue Regeneration: Fetal to adult transition
7. Chronic wounds and tissue engineering: Prospects and promise
Section 2: Stem Cell Research and Tissue Engineering
8. Emerging bioengineering strategies for regulating stem cell fate: Scaffold physical and biochemical cues
9. Stem cell research and tissue engineering
Section 3: Tissue Engineering and Nanomedicine
10. Nanomatrix and organ regeneration
11. Future of nanotechnology in tissue engineering
12. Green Nanotechnology in cardiovascular tissue engineering
Section 4: Soft Tissue Engineering
13. Retinal repair in tissue engineering perspectives
14. Dental pulp tissue regeneration
15. Prospects of collagen scaffolds for muscle regeneration
16. Nerve tissue engineering on degradable scaffold
17. Bioengineering of brain organoids: Advancements and challenges
18. 3D bio printing/additive manufacturing in tissue engineering
19. Biosensors in tissue engineering
20. Cardiovascular regenerations
Section 5: Hard Tissue Engineering
21. Bone tissue engineering
22. Dental tissue engineering
23. Musculoskeletal tissue engineering
Section 6: Regulatory guidelines, modeling, management, and ethical issues in translational tissue engineering
24. Translational tissue engineering
25. Tissue engineered products
translational avenues
26. 3D Modeling of the lung in health and disease
27. Modeling viral infection with tissue engineering: COVID-19 and the next outbreaks
28. Ethical issues
Authors
Chandra P. Sharma Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, India. Dr. Chandra P. Sharma is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Kathmandu, Nepal. Dr. Sharma is a Solid-State Physicist from IIT Delhi and received his training in Biomaterials area in the University of Utah with Prof. D.J. Lyman as a graduate student and in the University of Liverpool, England with Prof. D.F. Williams as a Post-Doctoral Research Associate. Dr. Sharma has been awarded FBSE (Fellow Biomaterials Science & Engineering) by The International Union of Societies for Biomaterials Science & Engineering (IUS-BSE) in 2008 and FBAO (Fellow Biomaterials and Artificial Organs) by Society for Biomaterials & Artificial Organs (India) (SBAOI) in 2011 and shares Whitaker and National Science Foundation Award - International Society for Artificial Organs (ISAO) USA, invited member ACS (2015-2018). Thomas Chandy Senior Test Engineer and Project Lead, Phillips Medisize, Hudson, Wisconsin, USA. Dr. Thomas Chandy is a biomaterial expert with unique combination of medical device and technical knowledge. He has strong academic credentials in human physiology and bio-compatible materials with test methods and model development. Dr. Chandy has published over 80 scientific papers in international Journals and 3 patents in the medical device and drug delivery area. Reviewer to 7+ international journals of repute in Drug delivery and Biomedical Research. Twenty-Five years of experience as a project lead in medical device and technology development. Strong experience with broad range of medical products including polymeric and tissue-based implantable, site specific drug delivery, medical diagnostics and combination devices. Product/process development skills with demonstrated success from concept through commercialization involving selection of materials, characterization, biological evaluation of materials, bench, feasibility tests and pre-clinical (animal) testing. Vinoy Thomas Assistant Professor, Department of Materials Science and Engineering, University of Alabama, Birmingham, USA.Dr. Vinoy Thomas is an Associate Professor and Graduate Program Director in the Department of Mechanical and Materials Engineering at the University of Alabama at Birmingham. He also holds secondary appointments at the Department of Biomedical Engineering, Department of Physics and Department of Environmental Science & Health. Dr. Thomas is also an Associate Scientist at the Center for Nanoscale Materials and Biointegration (CNMB) and Center for Clinical and Translational Sciences (CCTS). After his PhD in Biomaterials & Technology, he completed postdoctoral training at Friedrich-Schiller University (FSU), Jena, Germany, and at the National Institute of Standards & Technology (NIST), Gaithersburg, USA. His research focuses on biomaterials processing-property relationships, nanomaterials for tissue engineering and drug delivery . He has published over 120 scientific research and review articles (h- index: 36), co-edited two books (Tissue Engineering, Elsevier 2022 and Artificial Intelligence in Tissue and Organ Regeneration, Elsevier 2023). He serves as Associate Editor of Heliyon (Engineering). Dr. Thomas received Fellow Awards such as FBAO -from Society for Biomaterials and Artificial Organs India, FAAS- from Alabama Academy of Sciences, and IAAM Scientist Medal from International Association of Advanced Materials, Sweden. Dr. Thomas is currently serving as the President of Alabama Academy of Science (AAS), Chairman of SBAOI- North American Chapter, and Secretary of Biomaterials Committee of The Minerals, Metals, and Materials Society (TMS).
Finosh G. Thankam Assistant Professor, Tissue Engineering and Regenerative Medicine, Department of Translational Research, Western University of Health Sciences, Pomona, California, USA. Dr. Finosh Thankam is an assistant professor and researcher in Tissue Engineering and Regenerative Medicine, in the Department of Translational Research, at the Western University of Health Sciences, in Pomona, CA. His undergraduate studies were in Biochemistry, before completing his post-graduate degree in Medical Biochemistry from Mahatma Gandhi University, in India. As a research fellow he was exposed to the new world of tissue engineering and regenerative medicine and published many original articles on various aspects of cardiac tissue engineering. His current research interests include investigating the pathogenesis of various musculoskeletal disorders, and cardiovascular diseases, and applying the knowledge and principles of tissue engineering to develop artificial tissue constructs to improve the care for the sufferers.