Given the Growing Demand for Interventions that Require Genetic Modification, the Market is Poised to Witness Substantial Growth in the Foreseen Future
Over the past few years, a number of advanced therapy medicinal products, including cell and gene therapies, have been developed and approved for the treatment of a variety of disease indications. In fact, as of 2020, close to 15 such therapeutics have received marketing approval across different regions worldwide. Further, over 1,000 clinical trials focused on the evaluation of cell and gene therapies have been registered globally. It is worth noting that the clinical success of these therapies heavily relies on the design and type of gene delivery vector used (in therapy development and / or administration). At present, several innovator companies are actively engaged in developing / producing viral and / or non-viral vectors for gene therapies. In this context, it is worth mentioning that multiple viral and non-viral vector based vaccine candidates are being developed against the novel coronavirus (SARS-CoV-2). As of January 2021, the WHO revealed that more than 55 such vaccines are under evaluation, while two viral vector based vaccines (AZD1222 and Sputnik V), being developed by AstraZeneca / Oxford University and Gamaleya Research Institute / Acellena Contract Drug Research and Development, have been approved. This is indicative of the lucrative opportunities for companies that have the required capabilities to manufacture vectors and gene therapies.
Vaccine production is a challenging process and dealing with vectors (viral and non-viral) further adds to the complexity. Therefore, outsourcing is a common practice among biopharmaceutical companies when it comes to vector development and / or manufacturing. Several players have developed / are developing versatile technology platforms for designing and manufacturing different types of gene delivery vehicles. Innovation in this segment of the pharmaceutical industry is presently focused on the enhancement of transduction efficiency and improving gene delivery efficiencies. In fact, some vector-related technology providers claim that their proprietary solutions have the ability to enable further improvements in existing genetically modified therapeutic products, and / or optimize affiliated manufacturing processes. The viral / non-viral vectors and gene therapy manufacturing market has also witnessed significant partnership activity in the recent past, especially now that COVID-19 vaccine developers are actively approaching such companies for their services. Given the growing demand for interventions that require genetic modification, the vector and gene therapy manufacturing market is poised to witness substantial growth in the foreseen future.
Scope of the Report
The “Viral Vectors, Non-Viral Vectors and Gene Therapy Manufacturing Market (4th Edition) by Scale of Operation (Preclinical, Clinical and Commercial), Type of Vector (AAV Vector, Adenoviral Vector, Lentiviral Vector, Retroviral Vector, Plasmid DNA and Others), Application Area (Gene Therapy, Cell Therapy and Vaccine), Therapeutic Area (Oncological Disorders, Inflammation & Immunological Diseases, Neurological Disorders, Ophthalmic Disorders, Muscle Disorders, Metabolic Disorders, Cardiovascular Disorders and Others), and Geographical Regions (North America, Europe, Asia Pacific, MENA, Latin America and Rest of the World): Industry Trends and Global Forecasts, 2021-2030” report features an extensive study of the rapidly growing market of vector and gene therapy manufacturing, focusing on contract manufacturers, as well as companies having in-house manufacturing facilities. The study presents an in-depth analysis of the various firms / organizations that are engaged in this domain, across different regions of the globe. Amongst other elements, the report includes:
- An overview of the current status of the market with respect to the players engaged (both industry and non-industry) in the manufacturing of viral, non-viral and other novel types of vectors, and gene therapies. It features information on the year of establishment, company size, location of headquarters, type of product manufactured (vector and gene therapy / cell therapy / vaccine), location of manufacturing facilities, purpose of production (in-house and contract services), scale of production (preclinical, clinical and commercial), type of vector manufactured (AAV, adenoviral, lentiviral, retroviral, plasmid DNA and others) and application area (gene therapy, cell therapy, vaccine and others).
- An analysis of the technologies offered / developed by the companies engaged in this domain, based on the type of technology (viral vector and non-viral vector related platform), purpose of technology (vector manufacturing, gene delivery, product manufacturing, transduction / transfection, vector packaging and other), scale of production (preclinical, clinical and clinical), type of vector (AAV, adenoviral, lentiviral, retroviral, non-viral and other viral vectors), application area (gene therapy, cell therapy, vaccine and others). It also highlights the most prominent players within this domain, in terms of number of technologies.
- A region-wise, company competitiveness analysis, highlighting key players engaged in the manufacturing of vectors and gene therapies, across key geographical areas, featuring a four-dimensional bubble representation, taking into consideration supplier strength (based on experience in this field), manufacturing strength (type of product manufactured, number of manufacturing facilities and number of application areas), service strength (scale of operation, number of vectors manufactured and geographical reach) and company size (small-sized, mid-sized and large).
- Elaborate profiles of key players based in North America, Europe and Asia-Pacific (shortlisted based on proprietary criterion). Each profile features an overview of the company / organization, its financial performance (if available), information related to its manufacturing facilities, vector manufacturing technology and an informed future outlook.
- An analysis of recent collaborations and partnership agreements inked in this domain since 2015; it includes details of deals that were / are focused on the manufacturing of vectors, which were analyzed on the basis of year of partnership, type of partnership (manufacturing agreement, product / technology licensing, product development, merger / acquisition, research and development agreement, process development / optimization, service alliance, production asset / facility acquisition, supply agreement and others), scale of production (laboratory, clinical and commercial), type of vector (AAV, adenoviral, lentiviral, retroviral, plasmid and others), region and most active players (in terms of number of partnerships).
- An analysis of the expansions related to viral vector and non-viral vector manufacturing, which have been undertaken since 2015, based on several parameters, such as year of expansion, type of expansion (new facility / plant establishment, facility expansion, technology installation / expansion, capacity expansion and others), type of vector (AAV, adenoviral, lentiviral, retroviral, plasmid and others), application area (gene therapy, cell therapy, vaccine and others) and geographical location of the expansion project.
- An analysis evaluating the potential strategic partners (comparing vector based therapy developers and vector purification product developers) for vector and gene therapy product manufacturers, based on several parameters, such as developer strength, product strength, type of vector, therapeutic area, pipeline strength (clinical and preclinical).
- An overview of other viral / non-viral gene delivery approaches that are currently being researched for the development of therapies involving genetic modification.
- An in-depth analysis of viral vector and plasmid DNA manufacturers, featuring three schematic representations, namely [A] a three dimensional grid analysis, representing the distribution of vector manufacturers (on the basis of type of vector) across various scales of operation and purpose of production (in-house operations and contract manufacturing services), [B] a logo landscape of viral vector and plasmid DNA manufacturers based on the type of organization (industry and non-industry) and company size (small-sized, mid-sized and large), and [C] a schematic world map representation, highlighting the geographical location of key vector manufacturing hubs.
- An analysis of the various factors that are likely to influence the pricing of vectors, featuring different models / approaches that may be adopted by product developers / manufacturers in order to decide the prices of proprietary vectors.
- An estimate of the overall, installed vector manufacturing capacity of industry players based on the information available in the public domain, and insights generated via both secondary and primary research. The analysis also highlights the distribution of the global capacity by company size (small-sized, mid-sized and large), scale of operation (clinical and commercial), type of vector (viral vector and plasmid DNA) and region (North America, Europe, Asia Pacific and the rest of the world).
- An informed estimate of the annual demand for viral and non-viral vectors, taking into account the marketed gene-based therapies and clinical studies evaluating vector-based therapies; the analysis also takes into consideration various relevant parameters, such as target patient population, dosing frequency and dose strength.
- A discussion on the factors driving the market and various challenges associated with the vector production process.
- An insightful discussion on the impact that the recent COVID-19 pandemic is likely to have on the vector and gene therapy manufacturing market. In addition, it features various strategies that different companies have adopted / may adopt in order to mitigate the challenges affiliated to the current global crisis.
One of the key objectives of this report was to evaluate the current market size and the future opportunity associated with the vector and gene therapy manufacturing market, over the coming decade. Based on various parameters, such as the likely increase in number of clinical studies, anticipated growth in target patient population, existing price variations across different types of vectors, and the anticipated success of gene therapy products (considering both approved and late-stage clinical candidates), we have provided an informed estimate of the likely evolution of the market in the short to mid-term and long term, for the period 2021-2030. In order to provide a detailed future outlook, our projections have been segmented on the basis of [A] scale of operation (preclinical, clinical and commercial), [B] type of vector (AAV vector, adenoviral vector, lentiviral vector, retroviral vector, plasmid DNA and others), [C] application area (gene therapy, cell therapy and vaccine), [D] therapeutic area (oncological disorders, inflammation & immunological diseases, neurological disorders, ophthalmic disorders, muscle disorders, metabolic disorders, cardiovascular disorders and others) and [E] geographical region (North America, Europe, Asia Pacific, MENA, Latin America and rest of the world). In order to account for future uncertainties and to add robustness to our model, we have provided three forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.
The research, analysis and insights presented in this report are backed by a deep understanding of key insights generated from both secondary and primary research. For the purpose of the study, we invited over 180 stakeholders to participate in a survey to solicit their opinions on upcoming opportunities and challenges that must be considered for a more inclusive growth. The opinions and insights presented in this study were also influenced by discussions held with senior stakeholders in the industry.
The report features detailed transcripts of interviews held with the following industry and non-industry players:
- Menzo Havenga (Chief Executive Officer and President, Batavia Biosciences)
- Nicole Faust (Chief Executive Officer & Chief Scientific Officer, CEVEC Pharmaceuticals)
- Jeffrey Hung (Chief Commercial Officer, Vigene Biosciences)
- Cedric Szpirer (Founder, Executive & Scientific Director, Delphi Genetics)
- Olivier Boisteau, (Co-Founder / President, Clean Cells), Laurent Ciavatti (Ex-Business Development Manager, Clean Cells) and Xavier Leclerc (Head of Gene Therapy, Clean Cells)
- Alain Lamproye (Ex-President of Biopharma Business Unit, Novasep)
- Joost van den Berg (Ex-Director, Amsterdam BioTherapeutics Unit)
- Bakhos A Tannous (Director, MGH Viral Vector Development Facility, Massachusetts General Hospital)
- Eduard Ayuso, DVM, PhD (Scientific Director, Translational Vector Core, University of Nantes)
- Colin Lee Novick (Managing Director, CJ Partners)
- Semyon Rubinchik (Scientific Director, ACGT)
- Astrid Brammer (Senior Manager Business Development, Richter-Helm)
- Marco Schmeer (Project Manager, Plasmid Factory) and Tatjana Buchholz (Ex-Marketing Manager, Plasmid Factory)
- Brain M Dattilo (Business Development Manager, Waisman Biomanufacturing)
- Beatrice Araud (ATMP Key Account Manager, EFS-West Biotherapy)
- Nicolas Grandchamp (R&D Leader, GEG Tech)
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.
Key Questions Answered
- Who are the leading players (contract service providers and in-house manufacturers) engaged in the development of vectors and gene therapies?
- Which region are the current manufacturing hubs for vectors and gene therapies?
- Which type of technologies are presently offered / being developed by the stakeholders engaged in this domain?
- Which companies are likely to partner with viral and non-viral vector contract manufacturing service providers?
- Which partnership models are commonly adopted by stakeholders engaged in this industry?
- What type of expansion initiatives are being undertaken by players in this domain?
- Which are the emerging viral and non-viral vectors used by players for the manufacturing of genetically modified therapies?
- How is the recent COVID-19 pandemic likely to impact the viral and non-viral vector, and gene therapy manufacturing market?
- What is the current, global demand for viral and non-viral vector, and gene therapies?
- How is the current and future market opportunity likely to be distributed across key market segments?
Chapter Outlines
Chapter 2 is an executive summary of the insights captured in our research. It offers a high-level view on the likely evolution of the vector and gene therapy manufacturing market in the short to mid-term, and long term.
Chapter 3 is a general introduction to the various types of viral and non-viral vectors. It includes a detailed discussion on the design, manufacturing requirements, advantages, limitations and applications of the currently available gene delivery vehicles. The chapter also features the clinical and approved pipeline of genetically modified therapies. Further, it includes a review of the latest trends and innovations in the contemporary vector manufacturing market.
Chapter 4 provides a detailed overview of more than 115 companies, featuring both contract service providers and in-house manufacturers that are actively involved in the production of viral vectors and / or gene therapies utilizing viral vectors. The chapter provides details on the year of establishment, company size, location of headquarters, type of product manufactured (vector and gene therapy / cell therapy / vaccine), location of manufacturing facilities, purpose of production (in-house and contract services), scale of production (preclinical, clinical and commercial), type of vector manufactured (AAV, adenoviral, lentiviral, retroviral, plasmid DNA and others) and application area (gene therapy, cell therapy, vaccine and others).
Chapter 5 provides an overview of around 65 industry players that are actively involved in the production of plasmid DNA and other non-viral vectors and / or gene therapies utilizing non-viral vectors. The chapter provides details on the the year of establishment, company size, location of headquarters, type of product manufactured (vector and gene therapy / cell therapy vaccine), location of plasmid DNA manufacturing facilities, purpose of production (in-house and contract services), scale of production (preclinical, clinical and commercial) and application area (gene therapy, cell therapy, vaccine and others).
Chapter 6 provides an overview of close to 90 non-industry players (academia and research institutes) that are actively involved in the production of vectors (both viral and non-viral) and / or gene therapies. The chapter provides details on the year of establishment, purpose of production (in-house and contract services), scale of production (preclinical, clinical and commercial), location of headquarters, type of vector manufactured (AAV, adenoviral, lentiviral, retroviral, plasmid DNA and others) and application area (gene therapy, cell therapy, vaccine and others).
Chapter 7 features an in-depth analysis of the technologies offered / developed by the companies engaged in this domain, based on the type of technology (viral vector and non-viral vector related platform), purpose of technology (vector manufacturing, gene delivery, product manufacturing, transduction / transfection, vector packaging and other), scale of production (preclinical, clinical and clinical), type of vector (AAV, adenoviral, lentiviral, retroviral, non-viral and other viral vectors), application area (gene therapy, cell therapy, vaccine and others) and leading technology providers.
Chapter 8 presents a detailed competitiveness analysis of vector manufacturers across key geographical areas, featuring a four-dimensional bubble representation, taking into consideration supplier strength (based on its experience in this field), manufacturing strength (type of product manufactured, number of manufacturing facilities and number of application area), service strength (scale of production, number of vectors manufactured and geographical reach) and company size (small-sized, mid-sized and large).
Chapter 9 features detailed profiles of some of the key players that have the capability to manufacture viral vectors / plasmid DNA in North America. Each profile presents a brief overview of the company, its financial information (if available), details on vector manufacturing facilities, manufacturing experience and an informed future outlook.
Chapter 10 features detailed profiles of some of the key players that have the capability to manufacture viral vectors / plasmid DNA in Europe. Each profile presents a brief overview of the company, its financial information (if available), details on vector manufacturing facilities, manufacturing experience and an informed future outlook.
Chapter 11 features detailed profiles of some of the key players that have the capability to manufacture viral vectors / plasmid DNA in Asia-Pacific. Each profile presents a brief overview of the company, its financial information (if available), details on vector manufacturing facilities, manufacturing experience and an informed future outlook.
Chapter 12 features in-depth analysis and discussion of the various partnerships inked between the players in this market, during the period, 2015-2020, covering analysis based on parameters such as year of partnership, type of partnership(manufacturing agreement, product / technology licensing, product development, merger / acquisition, research and development agreement, process development / optimization, service alliance, production asset / facility acquisition, supply agreement and others), scale of production (laboratory, clinical and commercial) and type of vector (AAV, adenoviral, lentiviral, retroviral, plasmid and others) most active players (in terms of number of partnerships).
Chapter 13 features an elaborate discussion and analysis of the various expansions that have been undertaken, since 2015. Further, the expansion activities in this domain have been analyzed on the basis of year of expansion, type of expansion (new facility / plant establishment, facility expansion, technology installation / expansion, capacity expansion and others), geographical location of the facility, type of vector (AAV, adenoviral, lentiviral, retroviral, plasmid and others) and application area (gene therapy, cell therapy, vaccine and others).
Chapter 14 highlights potential strategic partners (vector based therapy developers and vector purification product developers) for vector and gene therapy product manufacturers, based on several parameters, such as developer strength, product strength, type of vector, therapeutic area, pipeline strength (clinical and preclinical). The analysis aims to provide the necessary inputs to the product developers, enabling them to make the right decisions to collaborate with industry stakeholders with relatively more initiatives in the domain.
Chapter 15 provides detailed information on other viral / non-viral vectors (including alphavirus vectors, Bifidobacterium longum vectors, Listeria monocytogenes vectors, myxoma virus based vectors, Sendai virus based vectors, self-complementary vectors (improved versions of AAV), and minicircle DNA and Sleeping Beauty transposon vectors (non-viral gene delivery approach)) that are currently being utilized by pharmaceutical players to develop gene therapies, T-cell therapies and certain vaccines, as well. This chapter presents overview on all the aforementioned types of vectors, along with examples of companies that use them in their proprietary products. It also includes examples of companies that are utilizing specific technology platforms for the development / manufacturing of some of these novel vectors.
Chapter 16 presents a collection of key insights derived from the study. It includes a grid analysis, highlighting the distribution of viral vectors and plasmid DNA manufacturers on the basis of their scale of production and purpose of manufacturing (fulfilling in-house requirement / contract service provider). In addition, it consists of a logo landscape, representing the distribution of viral vector and plasmid DNA manufacturers based on the type of organization (industry / non-industry) and company size. The chapter also consists of six world map representations of manufacturers of viral / non-viral vectors (lentiviral, adenoviral, AAV and retroviral vectors, and plasmid DNA), depicting the most active geographies in terms of the presence of the organizations. Furthermore, we have provided a schematic world map representation to highlight the geographical locations of key vector manufacturing hubs across different continents.
Chapter 17 highlights our views on the various factors that may be taken into consideration while pricing viral vectors / plasmid DNA. It features discussions on different pricing models / approaches that manufacturers may choose to adopt to decide the prices of their proprietary products.
Chapter 18 features an informed analysis of the overall installed capacity of the vectors and gene therapy manufacturers. The analysis is based on meticulously collected data (via both secondary and primary research) on reported capacities of various small-sized, mid-sized and large companies, distributed across their respective facilities. The results of this analysis were used to establish an informed opinion on the vector production capabilities of the organizations by company size (small-sized, mid-sized and large), scale of operation (clinical and commercial), type of vector (viral vector and plasmid DNA) and region (North America, Europe, Asia Pacific and the rest of the world).
Chapter 19 features an informed estimate of the annual demand for viral and non-viral vectors, taking into account the marketed gene-based therapies and clinical studies evaluating vector-based therapies. This section offers an opinion on the required scale of supply (in terms of vector manufacturing services) in this market. For the purpose of estimating the current clinical demand, we considered the active clinical studies of different types of vector-based therapies that have been registered till date. The data was analyzed on the basis of various parameters, such as number of annual clinical doses, trial location, and the enrolled patient population across different geographies. Further, in order to estimate the commercial demand, we considered the marketed vector-based therapies, based on various parameters, such as target patient population, dosing frequency and dose strength.
Chapter 20 presents a comprehensive market forecast analysis, highlighting the likely growth of vector and gene therapy manufacturing market till the year 2030. We have segmented the financial opportunity on the basis of [A] type of vectors (AAV vector, adenoviral vector, lentiviral vector, retroviral vector, plasmid DNA and others), [B] applications (gene therapy, cell therapy and vaccine), [C] therapeutic area (oncological disorders, inflammation & immunological diseases, neurological disorders, ophthalmic disorders, muscle disorders, metabolic disorders, cardiovascular disorders and others), [D] scale of operation (preclinical, clinical and commercial) and [E] geography (North America, Europe, Asia Pacific, MENA, Latin America and rest of the world). Due to the uncertain nature of the market, we have presented three different growth tracks outlined as the conservative, base and optimistic scenarios.
Chapter 21 highlights the effect of recent coronavirus outbreak on the vector and gene therapy manufacturing market. It includes a brief discussion on the short-term and long-term impact of COVID-19 on the supply chain and market opportunity for vector and gene therapy manufacturers. In addition, it includes a brief section on strategies and action plans that pharmaceutical and biopharmaceutical companies are likely to adopt in order to prepare for supply chain disruptions in future.
Chapter 22 provides details on the various factors associated with popular viral vectors and plasmid DNA that act as market drivers and the various challenges associated with the production process. This information has been validated by soliciting the opinions of several industry stakeholders active in this domain.
Chapter 23 presents insights from the survey conducted on over 180 stakeholders involved in the development of different types of gene therapy vectors. The participants, who were primarily Director / CXO level representatives of their respective companies, helped us develop a deeper understanding on the nature of their services and the associated commercial potential.
Chapter 24 summarizes the overall report. The chapter presents a list of key takeaways and offers our independent opinion on the current market scenario and evolutionary trends that are likely to determine the future of this segment of the industry.
Chapter 25 is a collection of transcripts of the interviews conducted with representatives from renowned organizations that are engaged in the vector and gene therapy manufacturing domain. In this study, we spoke to Menzo Havenga (Chief Executive Officer and President, Batavia Biosciences), Nicole Faust (Chief Executive Officer & Chief Scientific Officer, CEVEC Pharmaceuticals), Jeffrey Hung (Chief Commercial Officer, Vigene Biosciences), Cedric Szpirer (Founder, Executive & Scientific Director, Delphi Genetics), Olivier Boisteau, (Co-Founder / President, Clean Cells), Laurent Ciavatti (Ex-Business Development Manager, Clean Cells) and Xavier Leclerc (Head of Gene Therapy, Clean Cells), Alain Lamproye (Ex-President of Biopharma Business Unit, Novasep), Joost van den Berg (Ex-Director, Amsterdam BioTherapeutics Unit), Bakhos A Tannous (Director, MGH Viral Vector Development Facility, Massachusetts General Hospital), Eduard Ayuso, DVM, PhD (Scientific Director, Translational Vector Core, University of Nantes), Colin Lee Novick (Managing Director, CJ Partners), Semyon Rubinchik (Scientific Director, ACGT), Astrid Brammer (Senior Manager Business Development, Richter-Helm), Marco Schmeer (Project Manager, Plasmid Factory) and Tatjana Buchholz (Ex-Marketing Manager, Plasmid Factory), Brain M Dattilo (Business Development Manager, Waisman Biomanufacturing), Beatrice Araud (ATMP Key Account Manager, EFS-West Biotherapy) and Nicolas Grandchamp (R&D Leader, GEG Tech).
Chapter 26 is an appendix, which provides tabulated data and numbers for all the figures in the report.
Table of Contents
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 4D Molecular Therapeutics
- Abbott
- AbbVie
- Abeona Therapeutics
- Abintus Bio
- Accinov(acquired by ABL Europe)
- Acucela
- Adaptimmune Therapeutics
- AdaptVac
- Addgene
- Aduro Biotech
- Advanced BioScience Laboratories
- Advanced Biotherapeutics Consulting
- Advantagene
- Advaxis
- Advent
- Adverum Biotechnologies
- Aevitas Therapeutics (a subsidiary of Fortress Biotech)
- AffyImmune Therapeutics
- AGC Biologics
- Agenzia Italiana del Farmaco
- Agilent Technologies
- Agilis Biotherapeutics (acquired by PTC Therapeutics)
- Ajinomoto Althea
- Akdeniz University
- Akron Biotech
- Aldevron
- Allele Biotechnology
- Allergan
- Allife Medicine
- Allogene Therapeutics
- Alma Bio Therapeutics
- AlphaVax
- ALSTEM
- Althea Technologies
- Altimmune
- Altor BioScience
- American Gene Technologies
- Amgen
- Amicus Therapeutics
- Ampersand Capital Partners
- AMSBIO
- Amsterdam BioTherapeutics Unit
- Amsterdam Molecular Therapeutics ( acquired by uniQure)
- Anaeropharma Science
- Anemocyte
- AnGes
- Angionetics
- Annapurna Therapeutics ( acquired by Avalanche Biotechnologies)
- apceth Biopharma
- ApollobBo
- Applied Biological Materials
- Applied Genetic Technologies (AGTC)
- Applied Viromics
- Arcellx
- ARCO Design/Build
- ArcticZymes Technologies
- Areta International
- Aruvant Sciences
- ASC Therapeutics
- Asklepios BioPharmaceutical
- Astellas Pharma
- AstraZeneca
- Atara Biotherapeutics
- Atlantic Bio
- Atsena Therapeutics
- ATVIO Biotech
- Audentes Therapeutics
- Aurora Biopharma
- Autolus Therapeutics
- Avecia Biologics
- AveXis
- AVROBIO
- Axovant Gene Therapies
- Bamboo Therapeutics
- Batavia Biosciences
- Baylor College of Medicine
- BCM Families Foundation
- Beam Therapeutics
- Beckman Research Institute
- Beijing Biohealthcare Biotechnology
- Beijing Doing Biomedical
- Beijing HuiNengAn Biotech
- Beijing Immunochina Medical Science & Technology
- Beijing Mario Biotechnology
- Beijing Sanwater Biological Technology
- Bellicum Pharmaceuticals
- Benitec Biopharma
- BIA Separations
- Bio-Gene Technology
- Bio-Rad Laboratories
- Bioceltech Therapeutics
- BioCentriq
- Biogen
- BioInvent International
- BioMarin Pharmaceutical
- Biomay
- Biomiga
- Bionic Sight
- BioNTech Innovative Manufacturing Service
- BioReliance
- BioVec Pharma
- Bioverativ
- Biovian
- BioVision
- Blue Sky BioServices
- bluebird bio
- Boehringer Ingelheim BioXcellence
- BoYuan RunSheng Pharma
- Brain Neurotherapy Bio
- Brammer Bio
- Bristol Myers Squibb
- California Institute of Technology
- Cambridge Gene Therapy
- Cancer Research UK
- Candel Therapeutics
- Carina Biotech
- Carmine Therapeutics
- CARsgen Therapeutics
- Cartesian Therapeutics
- Casey Eye Institute
- Castle Creek Biosciences
- Catalent Biologics
- Celgene
- Cell and Gene Therapy Catapult
- Cell Biolabs
- Cellectis
- CellGenTech
- Cellular Biomedicine Group
- CellVec
- Celonic
- Celsion
- Celyad Oncology
- Center for Breakthrough Medicines
- Centre for Commercialization of Regenerative Medicine
- Centre for Process Innovation
- CEVEC Pharmaceuticals
- CG Oncology
- Children's Hospital of Philadelphia
- Children’s Medical Research Institute (CMRI)
- China Immunotech (Beijing) Biotechnology
- Chongqing Precision Biotech
- Choroideremia Research Foundation
- Cincinnati Children's Hospital Medical Center
- City of Hope
- Clean Cells
- Clinical BioManufacturing Facility (University of Oxford)
- Clino
- Cobra Biologics
- Cognate BioServices
- CombiGene
- Copernicus Therapeutics
- Cornell University
- Creative Biogene
- Creative Biolabs
- CSL Behring
- Cytiva
- CytoMed Therapeutics
- Daiichi Sankyo
- Delphi Genetics
- Denali Therapeutics
- DINAQOR
- DNAtrix
- Duke University
- Dyno Therapeutics
- Editas Medicine
- ElevateBio
- Elixirgen Scientific
- Emergent BioSolutions
- Emory University School of Medicine
- enGene
- Epeius Biotechnologies
- Errant Gene Therapeutics
- Esteve
- eTheRNA immunotherapies
- EUFETS
- Eureka Biotechnology
- Eurofins Genomics
- Eurofins Scientific
- ExcellGene
- Exothera
- Expression Therapeutics
- Eyevensys
- Fate Therapeutics
- FerGene
- FIMA
- FinVector
- Five Prime Therapeutics
- Flash Therapeutics
- Flexion Therapeutics
- Florida Biologix
- Formula Pharmaceuticals
- Fortress Biotech
- Fosun Pharma
- Foundation Fighting Blindness
- Fraunhofer Institute for Toxicology and Experimental Medicine
- Freeline Therapeutics
- FUJIFILM Diosynth Biotechnologies
- Fundamenta Therapeutics
- GE Healthcare Life Sciences
- GEG Tech
- Gen-X
- Genable Technologies
- Gene Therapy Research Institution
- GeneCopoeia
- GeneCure Biotechnologies
- GeneDetect
- GeneImmune Biotechnology
- Genelux
- GeneMedicine
- GeneOne Life Science
- Genethon
- GENEWIZ
- Genexine
- Genezen Laboratories
- GenIbet Biopharmaceuticals
- Genprex
- GenScript
- GenSight Biologics
- GenVec
- Genzyme
- GeoVax Labs
- GIGA
- GlaxoSmithKline
- Gracell Biotechnologies
- Gradalis
- Green Cross LabCell
- Grousbeck Gene Therapy Center
- Guangdong Xiangxue Precision Medical Technology
- Guangdong Zhaotai InVivo Biomedicine
- Guangzhou Anjie Biomedical Technology
- Guangzhou FineImmune Biotechnology
- Gyroscope Therapeutics
- Hadassah Medical Organization
- Handl Therapeutics
- Harvard Gene Therapy Initiative
- Hebei Senlang Biotechnology
- Heidelberg University Hospital
- Helixmith
- Hemera Biosciences
- Henan Hualong Biotechnology
- Herantis Pharma
- Hitachi Chemical Advanced Therapeutics Solutions
- Holostem Terapie Avanzate
- Homology Medicines
- Hong Kong Institute of Biotechnology
- Hookipa Biotech
- HORAMA
- Hrain Biotechnology
- Huadao biomedical
- Huapont Life Sciences
- Human Stem Cells Institute (HSCI)
- Hunan Zhaotai Yongren Medical Innovation
- Icahn School of Medicine at Mount Sinai
- iCAR Bio Therapeutics
- iCarTAB BioMed
- iCell Gene Therapeutics
- ID Pharma
- Ilya Pharma
- Immatics
- Immune Design
- Immune Technology
- Immunocore
- Immunomic Therapeutics
- Imperial Innovations
- Indiana University
- Innovative Cellular Therapeutics
- Inovio Pharmaceuticals
- InProTher
- Institute of Medical Science Research Hospital
- Institute of Translational Health Sciences
- Instituto de Tecnologia Química e Biológica (ITQB)
- International AIDS Vaccine Initiative (IAVI)
- InvivoGen
- IPPOX Foundation
- IVERIC bio
- Janssen Pharmaceuticals
- Juno Therapeutics
- Juventas Cell Therapy
- JW Therapeutics
- KAEDI
- Kaneka Eurogentec
- Karolinska Institutet
- Kecellitics Biotech
- King’s College London
- Kite Pharma
- Kobe Biomedical Innovation Cluster
- Kolon TissueGene
- Kriya Therapeutics
- Krystal Biotech
- Kuur Therapeutics
- Laboratory of Digital Sciences of Nantes
- LakePharma
- Legend Biotech
- Lentigen Technology
- Leucid Bio
- Leuven Viral Vector Core
- LEXEO Therapeutics
- Lion TCR
- Lipigon Pharmaceuticals
- LNBio
- LogicBio Therapeutics
- Lokon Pharma
- Lonza
- Louisiana State University School of Veterinary Medicine
- Luina Bio
- Luminous BioSciences
- Lund University
- Lysogene
- Magee-Womens Research Institute
- Maine Medical Center Research Institute (MMCRI)
- Marino Biotechnology
- Massachusetts Eye and Ear
- Massachusetts General Hospital
- MassBiologics
- MaxCyte
- Mayflower Bioscience
- Mayo Clinic Cancer Center
- MD Anderson Cancer Institute
- Medac
- Medigene
- MedImmune
- MeiraGTx
- Memorial Sloan Kettering Cancer Center
- Merck
- Microsoft
- Mila’s Miracle Foundation
- MilliporeSigma
- Milo Biotechnology
- Miltenyi Biotec
- Minerva Biotechnologies
- MingJu Therapeutics
- Mitsubishi Tanabe Pharma
- Molecular Diagnostic Services
- MolMed
- Momotaro-Gene
- MultiVir
- Mustang Bio
- Myeloma Crowd
- Nanjing Bioheng Biotech
- Nantes Gene Therapy Institute
- Naobios
- National Cancer Institute
- National Center for Advancing Translational Sciences
- National Eye Institute
- National Human Genome Research Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Environmental Health Sciences
- Nationwide Children's Hospital
- Nature Technology
- Naval Medical Research Center
- Neurimmune
- NeuroCure
- Neurophth Therapeutics
- Neuroscience Center Zurich
- New Jersey Innovation Institute (NJII)
- NewLink Genetics
- NHS Blood and Transplant
- Nikon CeLL innovation
- Noga Therapeutics
- Norgen Biotek
- Nouscom
- Novartis
- Novasep
- Odylia Therapeutics
- Okairos
- Omnia Biologics
- Oncolys BioPharma
- OncoSec
- OncoSenX
- ORCA Therapeutics
- Orchard Therapeutics
- Oregon Health & Science University
- OS Therapies (OST)
- Otonomy
- Oxford BioMedica
- Oxford Genetics
- OXGENE
- OZ Biosciences
- PACT Pharma
- Pall Biotech
- Paragon Bioservices
- PeriphaGen
- PersonGen BioTherapeutics
- Pfizer
- PharmaCell
- PhorMed
- Pinze Lifetechnology
- PlasmidFactory
- Poseida Therapeutics
- Precigen
- Precision BioSciences
- Prevail Therapeutics
- ProBioGen
- Progenics Pharmaceuticals
- ProMab Biotechnologies
- Protheragen
- Provecs Medical
- PsiOxus Therapeutics
- PTC Therapeutics
- Puresyn
- Quethera
- Regeneron Pharmaceuticals
- REGENXBIO
- ReiThera
- Renova Therapeutics
- Rentschler Biotechnologie
- Richter-Helm BioLogics
- Roche
- Rocket Pharmaceuticals
- Roswell Park Comprehensive Cancer Center
- Rubius Therapeutics
- SAB Technology
- SAFC
- Saiba
- Salk Institute for Biological Studies
- San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget)
- Sanford Burnham Prebys Medical Discovery Institute
- Sangamo Therapeutics
- Sanofi
- Santen Pharmaceutical
- Sarepta Therapeutics
- Sartorius Stedim Biotech
- Scancell
- Seattle Children's Research Institute
- Selecta Biosciences
- Servier
- Shanghai Biomed-union Biotechnology
- Shanghai Bioray Laboratory
- Shanghai Cell Therapy
- Shanghai GeneChem
- Shanghai Longyao Biotechnology
- Shanghai PerHum Therapeutics
- Shanghai Sunway Biotech
- Shanghai Unicar-Therapy Bio-medicine Technology
- Shenzhen Binde Biotechnology
- Shenzhen SiBiono GeneTech
- SignaGen Laboratories
- SillaJen
- Simcere Pharmaceutical
- Sinobioway Cell Therapy
- SIRION Biotech
- Solid Biosciences
- Sorrento Therapeutics
- Spark Therapeutics
- SQZ Biotechnologies
- St. Jude Children's Research Hospital
- Stanford University
- Symbiosis Pharmaceutical Services
- Synpromics
- Synthace
- System Biosciences
- Takara Bio
- Takeda Pharmaceutical
- Targovax
- TCR2 Therapeutics
- TCRCure Biopharma
- tebu-bio
- Telethon Institute of Genetics and Medicine (TIGEM)
- Terry Fox Laboratory
- Tessa Therapeutics
- The Beijing Pregene Science and Technology
- The Jackson Laboratory
- The Jenner Institute
- The Michael J. Fox Foundation
- The Native Antigen
- The Pregene (ShenZhen) Biotechnology
- The University of Tennessee Health Science Center
- TheraBiologics
- Theravectys
- Thermo Fisher Scientific
- Tianjin Mycure Medical Technology
- Timmune Biotech
- Tmunity Therapeutics
- Tolerion
- Touchlight Genetics
- Transgene
- Treeway
- Trizell
- Twist Bioscience
- TxCell
- UC Davis
- UC San Diego School of Medicine
- UK Cystic Fibrosis Gene Therapy Consortium
- Ultragenyx Pharmaceutical
- uniQure
- Universitat Autònoma de Barcelona-Vall d'Hebrón Institut de Recerca
- University College London
- University Medical Center Groningen
- University of Adelaide
- University of Eastern Finland
- University of Florida
- University of Iowa Carver College of Medicine
- University of Massachusetts Medical School
- University of Michigan Medical Center
- University of Minnesota
- University of North Carolina
- University of Pennsylvania
- University of Pittsburgh
- University of South Carolina School of Medicine
- University of Southampton
- University of Tokyo
- University of Virginia School of Medicine
- Unum Therapeutics (now Cogent Biosciences)
- Urovant Sciences
- USC School of Pharmacy
- UWELL Biopharma
- Vaccine Manufacturing and Innovation Centre (VMIC)
- Vaccitech
- VBL Therapeutic
- VCN Biosciences
- Vector Biolabs
- Vecura
- VGXI
- Vibalogics
- Vical
- Vigene Biosciences
- Vineti
- Viralgen
- Virapur
- ViraQuest
- ViroMed
- Virovek
- VirusTech
- VIVEbiotech
- Voyager Therapeutics
- Waisman Biomanufacturing
- Washington University School of Medicine
- Wellington Zhaotai Therapies
- Wuhan Bio-Raid Biotechnology
- Wuhan Sian Medical Technology
- WuXi AppTec
- Wyvern Pharmaceuticals
- Xiangxue Life Sciences
- Xpress Biologics
- XyloCor Therapeutics
- Xyphos Biosciences
- Yake Biotechnology
- Yposkesi
- Yufan Biotechnology
- Ziopharm Oncology
Methodology
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