Neurological Complications of Systemic Cancer and Antineoplastic Therapy. Edition No. 2

Table of Contents

SECTION I. Metastatic Neurological Complications 1. Common symptoms at presentation of nervous system metastases 2. Neuroimaging of systemic metastatic disease 3. Nonimaging evaluation of patients with nervous system metastases 4. Biology and pathophysiology of central nervous system metastases 5. Intracranial metastases 6. Neurosurgical approaches to the treatment of intracranial metastases 7. Epidural metastasis and spinal cord compression 8. Leptomeningeal metastasis 9. Cranial nerve involvement by metastatic cancer 10. Cancer-related plexopathies

SECTION II.�Nonmetastatic Neurological Complications 11. Cerebrovascular complications of malignancy 12. Metabolic and nutritional nervous system dysfunction in cancer patients 13. Central nervous system infections in cancer patients 14. Diagnosis and treatment of paraneoplastic neurological disorders

SECTION III.�Neurological Complications of Specific Neoplasms 15. Neurological complications of lung cancer 16. Neurological complications of breast cancer 17. Neurological complications of melanoma 18. Neurological complications of lymphoma 19. Neurological complications of the leukemias 20. Neurological complications of systemic cancer of the head and neck������������������������������������������������������������� 21. Neurological complications of gynecological cancers 22. Neurological complications of GI cancers 23. Neurologic complications associated with genitourinary cancer 24. Sarcoma and the nervous system 25. Neurological complications of multiple myeloma 26. Neurologic complications in the treatment of childhood malignancies

SECTION IV.�Neurological Complications of Antineoplastic Therapy 27. Neurological complications of radiation therapy 28. Neurological complications of systemic cancer and antineoplastic therapy 29. Neurological complications of hematopoietic stem cell transplantation 30. Chemotherapy-induced peripheral neuropathy 31. Neurological complications of immunotherapy and monoclonal antibody therapy 32. Neurological complications of immune modulatory therapy 33. Neurological complications of steroids and of supportive care

SECTION V.�Psychiatric, Pain, Psychosocial, and Supportive Care Issues 34. Psychiatric aspects of care in the cancer patient 35. Chronic cancer pain syndromes and their treatment 36. Psychosocial issues in cancer patients with neurological complications 37. Supportive care

Authors

Herbert B. Newton Advent Health Cancer Institute, FL, USA. Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Advent Health Cancer Institute and Advent Health Orlando Campus. He recently retired as Professor of Neurology and Neurosurgery at the Ohio State University Medical Center and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro-Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York, and since then had been in academic Neuro-Oncology for over 25 years. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of ten textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 18 years. Mark G. Malkin Director of the Neuro-Oncology Program at Massey Cancer Center; Director of the Neuro-Oncology Division, Department of Neurology, Professor of Neurology and Neurosurgery, William G. Reynolds, Jr. Chair in Neuro-Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States. Dr. Malkin is currently the Director of the Neuro-Oncology Program at Massey Cancer Center, and Director of the Neuro-Oncology Division, in the Department of Neurology at Virginia Commonwealth University School of Medicine. He holds the William G. Reynolds, Jr. Chair in Neuro-Oncology and is Professor of Neurology. Before his appointment at VCU, he was the Director of Neuro-Oncology and Professor of Neurology at Froedtert and the Medical College of Wisconsin. Prior to his move to Milwaukee, he was an Associate Clinical Member at Memorial Sloan-Kettering Cancer Center and Associate Clinical Professor of Neurology at Weill Cornell Medical College. He also trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center, and since then has been in academic Neuro-Oncology for over 33 years. He has published more than 100 peer-reviewed articles and book chapters and is Co-Editor of several textbooks in the field of Neuro-Oncology.