Overview
Alzheimer’s disease is a progressive neurological disorder characterized by the death of brain cells, eventually leading to memory loss, cognitive dysfunction and dementia. Accounting for 60-70% cases of dementia, Alzheimer’s disease is known to be the sixth leading cause of death in the US. Presently, more than 6 million Americans of all ages are living with Alzheimer's and this number is projected to reach around 13 million by 2050. In 2020, the healthcare burden associated with the disease was estimated to be around USD 305 billion. Given the socioeconomic burden associated with Alzheimer’s, pharmaceutical players have been on the lookout for reliable diagnostic tests and effective treatment alternatives that can slow the progression of this disease. However, not many drugs could make their way to the market and majority of the existing therapeutic approaches have proven ineffective in the treatment of Alzheimer’s disease and its related symptoms.
Recently, in June 2021, the FDA granted accelerated approval for the first disease modifying therapy, Aduhelm™ (Aducanumab), developed by Biogen, for the treatment of Alzheimer’s disease. The approval of this amyloid beta-directed antibody has sparked a ray of hope for other players which are seeking approval for similar therapies. Further, multiple partnerships have been forged by various established players and start-ups in this domain in order to expand their research efforts and respective product portfolios. In addition, venture capital and other strategic investors are providing the necessary financial support to the research initiatives being undertaken by start-ups. Given the ongoing efforts aimed at finding effective and potential therapeutic cure, we are led to believe that the Alzheimer’s disease market is likely to witness healthy growth in the coming years.
Scope of the Report
The “Alzheimer’s Disease Market (2nd Edition) by Type of Treatment (Symptomatic and Disease Modifying), Symptomatic Indications (Dementia, Insomnia and Other Psychological Symptoms) and Key Geographical Regions (North America, Europe and Asia-Pacific): Industry Trends and Global Forecasts, 2021-2030” report features an extensive study on the current landscape of the marketed, clinical and preclinical molecules available/being developed for the treatment of Alzheimer’s disease, offering an informed opinion on the likely evolution of the market, till 2030. The study underlines an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this domain.
Amongst other elements, the report features:
- A detailed review of the current market landscape of drugs developed for the treatment of Alzheimer’s, including analyses based on several relevant parameters, such as current status of development (marketed, clinical and pre-clinical), phase of development (phase IV, phase III, phase II/III, phase II, phase I/II and phase I) of lead candidates, type of biologic (antibodies, peptides, cell and gene therapy, protein and vaccines), target disease stage (early stage, mild stage, mild to moderate stage and moderate to severe stage), type of treatment (symptomatic treatment, disease modifying treatment and both), mechanism of action (inhibitor, activator and modulator), route of administration (oral, intravenous, subcutaneous and others), dosing frequency (single dose, daily, twice daily, thrice daily, weekly, biweekly, monthly) type of therapy (monotherapy and combination therapy) and path to clinic (dedicated, repositioned and repurposed). Additionally, the report provides information on drug developer(s) involved in the domain, along with analyses based on a number of relevant parameters, such as year of establishment, company size and geographical location of headquarters.
- A detailed analysis of completed, ongoing and planned clinical trials of the drugs for the treatment of Alzheimer’s disease and its related symptoms, on the basis of several relevant parameters, such as trial status, trial registration year, type of sponsor/collaborator, type of study design, enrolled patient population, age category, leading industry sponsors/collaborators (in terms of number of trials conducted) and regional distribution of trials.
- Elaborate profiles of the key players involved in the development of therapeutics for Alzheimer’s disease. Each profile features a brief overview of the company, its financial information, details on its product portfolio, and recent developments and an informed future outlook.
- An in-depth analysis of grants that have been awarded to various research institutes for projects related to Alzheimer’s disease, in the period between 2017 and 2021, on the basis of important parameters, such as year of grant award, grant amount awarded, administering institute center, support period, type of grant application, grant activity code, emerging focus area, purpose of grant award, type of recent organization, popular NIH department and prominent program officers.
- An analysis of the partnerships established between various stakeholders in this domain, during the period 2017-2021, covering product development and commercialization agreements, R&D agreements, technology/product licensing agreements, other licensing agreements, mergers and acquisitions, clinical trial agreements and other relevant types of deals.
- A review of the funding and investments made in the domain, in the period between 2017 and 2021, including seed financing, venture capital financing, debt financing, grants, capital raised from IPOs and subsequent offerings, at various stages of development. The analysis has been done on the basis of several parameters, such as number of funding instances, amount invested, type of funding, leading players and investors, and geographical analysis.
- A detailed assessment of discontinued drugs and terminated trials, providing information on the year of discontinuation, reason(s) for discontinuation, phase of discontinuation, mechanism of action of the terminated drugs, type of indication, reason for termination, affiliated stakeholders.
- A detailed review of around 20,000 peer-reviewed, scientific articles related to research on Alzheimer’s disease, which have been published between 2017 and June 2021, including analysis based on parameters, such as year of publication, key focus area, type of molecule, popular keywords, and key journals (in terms of number of articles published in this domain and impact factor of the journal).
- An in-depth analysis of the patents related to Alzheimer’s disease, filed/granted since 2017, based on various parameters, such as patent publication year, geographical location/patent jurisdiction, CPC symbols, emerging focus areas, and type of applicant, and leading players (by number of patents). In addition, it features a patent valuation analysis which evaluates the qualitative and quantitative aspects of the patents.
One of the key objectives of the report was to estimate the existing market size and the future growth opportunities for therapies being developed for the treatment of Alzheimer’s disease, over the next decade. Based on multiple parameters, such as disease prevalence, anticipated adoption rates and the selling price/likely selling price of therapies for the disease, we have developed informed estimates on the evolution of the market for the period 2021-2030 The report also features the likely distribution of the current and forecasted opportunity across [A] type of treatment (symptomatic and disease modifying treatment) [B] symptomatic indications (dementia, insomnia and other psychological symptoms) and [C] key geographical regions (North America, Europe and Asia-Pacific). To account for the future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, portraying different tracks of the anticipated industry’s growth. The opinions and insights presented in this study were influenced by inputs solicited via a comprehensive survey and discussions conducted with several key players in this domain. The report features detailed transcripts of interviews held with the following industry stakeholders:
- Kenneth Moch (President and Chief Executive Officer, Cognition Therapeutics)
- Mathias Schmidt (Chief Executive Officer, ArmaGen)
- Ram Bhatt (Chief Executive Officer, Chairman and Founder, ICB International)
All actual figures have been sourced and analyzed from publicly available information forums. Financial figures mentioned in this report are in USD, unless otherwise specified.
Key Questions Answered
- Who are the leading industry players involved in the Alzheimer’s disease industry?
- Which geographies are the most active in conducting clinical trials on therapies for Alzheimer’s disease?
- Which are the leading funding organizations providing grants in the Alzheimer’s disease industry?
- Which partnership models are commonly adopted by industry stakeholders in the Alzheimer’s disease industry?
- How is the current and future market opportunity, related to Alzheimer’s disease, likely to be distributed across key market segments?
Table of Contents
1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Key Questions Answered
1.4. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. An Overview of Alzheimer’s Disease
3.1.1. Alzheimer’s Disease: Signs and Symptoms
3.1.2. Causes of Alzheimer’s Disease
3.1.3. Stages of Alzheimer’s Disease
3.2. Alzheimer’s Disease Management: Programs Undertaken by The National Institutes of Health
3.3. Alzheimer’s Disease Management
3.4. Digital Biomarkers in Alzheimer’s Disease
3.4.1. Potential of Digital Biomarkers in Alzheimer’s Disease
3.4.2. Sensors or Digital Senses in Wearable / Mobile Devices for Alzheimer’s Disease
4. PIPELINE REVIEW: MARKETED AND CLINICAL- STAGE DRUGS
4.1. Analysis Methodology and Key Parameters
4.2. Alzheimer’s Disease Therapies: Marketed and Development Pipeline
4.2.1. Analysis by Phase of Development
4.2.2. Analysis by Type of Molecule
4.2.3. Analysis by Target Disease Stage
4.2.4. Analysis by Type of Treatment
4.2.5. Analysis by Mechanism of Action
4.2.6. Analysis by Route of Administration
4.2.7. Analysis by Dosing Frequency
4.2.8. Analysis by Type of Therapy
4.2.9. Analysis by Path to Clinic
4.2.10. Grid Analysis: Distribution by Phase of Development, Path to Clinic and Type of Therapy
4.3. Alzheimer’s Disease Therapies: List of Developers
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Company Size and Geographical Location of Headquarters
4.3.3. Leading Players: Analysis by Number of Therapies
4.3.4. Analysis by Geography
5. COMPANY PROFILES
5.1. AbbVie
5.1.1. Company Overview
5.1.2. Financial Information
5.1.3. Product Portfolio
5.1.4. Recent Developments and Future Outlook
5.2. AC Immune
5.2.1. Company Overview
5.2.2. Financial Information
5.2.3. Product Portfolio
5.2.4. Recent Developments and Future Outlook
5.3. Biogen
5.3.1. Company Overview
5.3.2. Financial Information
5.3.3. Product Portfolio
5.3.4. Recent Developments and Future Outlook
5.4. Eisai
5.4.1. Company Overview
5.4.2. Financial Information
5.4.3. Product Portfolio
5.4.4. Recent Developments and Future Outlook
5.5. Eli Lilly and Company
5.5.1. Company Overview
5.5.2. Financial Information
5.5.3. Product Portfolio
5.5.4. Recent Developments and Future Outlook
5.6. GlaxoSmithKline
5.6.1. Company Overview
5.6.2. Financial Information
5.6.3. Product Portfolio
5.6.4. Recent Developments and Future Outlook
5.7. Grifols
5.7.1. Company Overview
5.7.2. Financial Information
5.7.3. Product Portfolio
5.7.4. Recent Developments and Future Outlook
5.8. Janssen Pharmaceutical
5.8.1. Company Overview
5.8.2. Financial Information
5.8.3. Product Portfolio
5.8.4. Recent Developments and Future Outlook
5.9. Neurim Pharmaceuticals
5.9.1. Company Overview
5.9.2. Financial Information
5.9.3. Product Portfolio
5.9.4. Recent Developments and Future Outlook
5.10. Novartis
5.10.1. Company Overview
5.10.2. Financial Information
5.10.3. Product Portfolio
5.10.4. Recent Developments and Future Outlook
5.11. Novo Nordisk
5.11.1. Company Overview
5.11.2. Financial Information
5.11.3. Product Portfolio
5.11.4. Recent Developments and Future Outlook
5.12. Roche
5.12.1. Company Overview
5.12.2. Financial Information
5.12.3. Product Portfolio
5.12.4. Recent Developments and Future Outlook
5.13. Takeda Pharmaceutical
5.13.1. Company Overview
5.13.2. Financial Information
5.13.3. Product Portfolio
5.13.4. Recent Developments and Future Outlook
6. CASE STUDY: TERMINATED DRUGS
6.1. Chapter Overview
6.2. Alzheimer’s Disease Therapies: List of Terminated Drugs
6.2.1. Analysis by Year of Discontinuation
6.2.2. Analysis by Phase of Discontinuation
6.2.3. Analysis by Mechanism of Action
6.2.4. Analysis by Type of Indication
6.2.5. Analysis by Reason for Termination
6.2.6. Analysis by Affiliated Stakeholders
6.3. Alzheimer’s Disease Therapies: List of Terminated Clinical Trials
6.3.1. Distribution by Study Start Year and Year of Termination of Clinical Trials
6.3.2. Analysis by Location of Trials
6.4. Concluding Remarks
7. PUBLICATION ANALYSIS
7.1. Analysis Methodology and Key Parameters
7.2. Alzheimer’s Disease: List of Publications
7.3. Analysis by Year of Publication
7.4. Analysis by Key Focus Area
7.5. Word Cloud of Study Titles
7.6. Top Journal: Analysis by Number of Publications
7.6. Top Author: Analysis by Number of Publications
8. PARTNERSHIPS AND COLLABORATIONS
8.1. Analysis Methodology and Key Parameters
8.2. Partnership Models
8.3. Alzheimer’s Disease: List of Partnerships and Collaborations
8.3.1. Analysis by Year of Partnership
8.3.2. Analysis by Type of Partnership
8.3.3. Analysis by Type of Partnership and Focus Area of Partnership
8.3.4. Analysis by Type of Partnership and Type of Molecule
8.3.5. Most Active Players: Analysis by Number of Partnerships
8.3.6. Regional Analysis
8.3.7. Intercontinental and Intracontinental Agreements
9. FUNDING AND INVESTMENT ANALYSIS
9.1. Analysis Methodology and Key Parameters
9.2. Types of Funding
9.3. Funding and Investment Analysis
9.3.1. Analysis by Year of Investment
9.3.2. Analysis by Amount Invested
9.3.3. Analysis by Type of Funding
9.3.4 Analysis by Amount Invested Across Different Types of Molecules
9.3.5 Analysis by Amount Invested Across Different Types of Mechanism of Action
9.3.6. Regional Analysis by Amount Invested
9.3.7. Most Active Players: Analysis by Number of Funding Instances
9.3.8. Most Active Investors: Analysis by Amount Funded
10. GRANT ANALYSIS
10.1. Analysis Methodology and Key Parameters
10.2. Alzheimer’s Disease: List of Academic Grants
10.2.1. Analysis by Year of Grant Award
10.2.2. Analysis by Grant Amount Awarded
10.2.3. Analysis by Administering Institute Center
10.2.4. Analysis by Support Period
10.2.5. Analysis by Administering Institute Center and Support Year
10.2.6. Analysis by Type of Grant Application
10.2.7. Analysis by Grant Activity Code
10.2.8. Word Cloud of Study Titles
10.2.9. Analysis by Purpose of Grant Award
10.2.10. Analysis by Type of Recipient Organization
10.2.11. Popular NIH Departments: Analysis by Number of Grants
10.2.12. Prominent Program Officers: Analysis by Number of Grants
11. CLINICAL TRIAL ANALYSIS
11.1. Analysis Methodology and Key Parameters
11.2. Alzheimer’s Disease: Clinical Trial Analysis
11.3.1. Analysis by Trial Status
11.3.2. Analysis by Trial Registration Year
11.3.3. Analysis by Type of Sponsor / Collaborator
11.3.3. Analysis by Type of Study Design
11.3.4. Analysis by Registration Year and Type of Study
11.3.5. Analysis by Patient Enrollment
11.3.6. Year-wise Trend of Completed and Recruiting Trials
11.3.7. Analysis by Age Category
11.3.8. Word Cloud of Study Titles
11.3.9. Most Active Industry Players: Analysis by Number of Registered Trials
11.3.10. Most Active Non- Industry Players: Analysis by Number of Registered Trials
11.3.11. Analysis by Trial Location
11.3.12. Analysis by Trial Status and Geography
12. PATENT ANALYSIS
12.1. Analysis Methodology and Key Parameters
12.2. Alzheimer’s Disease: Patent Analysis
12.2.1. Analysis by Patent Application Year
12.2.2. Analysis by Geography
12.2.3. Analysis by CPC Symbols
12.2.4. Word Cloud: Emerging Focus Areas
12.2.5. Analysis by Type of Applicant
12.2.6. Leading Players: Analysis by Number of Patents
12.2.7 Leading Players: Analysis by Number of International Patents
12.2.8. Patent Valuation Analysis
13. NON-PHARMACOLOGICAL INTERVENTIONS AND DIAGNOSTICS
13.1. Non-Pharmacological Interventions for Alzheimer’s Disease
13.1.1. Cognition / Emotion-Oriented Interventions
13.1.1.1. Reminiscence Therapy
13.1.1.2. Simulated Presence Therapy
13.1.2. Sensory Stimulation-based Interventions
13.1.2.1. Virtual Reality
13.1.2.2. Music Therapy
13.1.2.3. Light Therapy
13.1.2.4. Aromatherapy
13.1.2.5. Reflexology
13.1.3. Other Psycho-social Interventions
13.1.3.1. Animal-Assisted Therapy
14. MARKET SIZING AND OPPORTUNITY ANALYSIS
14.1. Forecast Methodology and Key Assumptions
14.2. Global Alzheimer’s Disease Market, 2021-2030
14.3. Global Alzheimer’s Disease Market, 2021-2030: Distribution by Type of Treatment
14.4. Global Alzheimer’s Disease Market, 2021-2030: Distribution by Type of Target Disease Indication
14.5. Global Alzheimer’s Disease Market, 2021-2030: Distribution by Geography
14.5.1. Alzheimer’s Disease Market in North America, 2021-2030
14.5.1.1. Alzheimer’s Disease Market in North America, 2021-2030: Distribution by Type of Treatment
14.5.1.1.1. Alzheimer’s Disease Market in North America, 2021-2030: Distribution by Symptomatic Treatment
14.5.1.1.1.1. Alzheimer’s Disease Market in North America, 2021-2030: Share of Dementia in Symptomatic Treatment Market
14.5.1.1.1.2. Alzheimer’s Disease Market in North America, 2021-2030: Share of Insomnia in Symptomatic Treatment Market
14.5.1.1.1.3. Alzheimer’s Disease Market in North America, 2021-2030: Share of Other Psychological Symptoms in Symptomatic Treatment Market
14.5.1.1.2. Alzheimer’s Disease Market in North America, 2021-2030: Distribution by Disease Modifying Treatment
14.5.2. Alzheimer’s Disease Market in Europe, 2021-2030
14.5.2.1. Alzheimer’s Disease Market in Europe, 2021-2030: Distribution by Type of Treatment
14.5.2.1.1. Alzheimer’s Disease Market in Europe, 2021-2030: Distribution by Symptomatic Treatment
14.5.2.1.1.1. Alzheimer’s Disease Market in Europe, 2021-2030: Share of Dementia in Symptomatic Treatment Market
14.5.2.1.1.2. Alzheimer’s Disease Market in Europe, 2021-2030: Share of Insomnia in Symptomatic Treatment Market
14.5.2.1.1.3. Alzheimer’s Disease Market in Europe, 2021-2030: Share of Other Psychological Symptoms in Symptomatic Treatment Market
14.5.2.1.2. Alzheimer’s Disease Market in Europe, 2021-2030: Distribution by Disease Modifying Treatment
14.5.3. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030
14.5.3.1. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Distribution by Type of Treatment
14.5.3.1.1. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Distribution by Symptomatic Treatment
14.5.3.1.1.1. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Share of Dementia in Symptomatic Treatment Market
14.5.3.1.1.2. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Share of Insomnia in Symptomatic Treatment Market
14.5.3.1.1.3. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Share of Other Psychological Symptoms in Symptomatic Treatment Market
14.5.3.1.2. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Distribution by Disease Modifying Treatment
15. CONCLUDING REMARKS
16. EXECUTIVE INSIGHTS
16.1. Cognition Therapeutics
16.1.1. Company Snapshot
16.1.1. Interview Transcript: Kenneth Moch (President and Chief Executive Officer)
16.2. ArmaGen
16.2.1. Company Snapshot
16.2.2. Interview Transcript: Mathias Schmidt (Chief Executive Officer)
16.2. ICB International
16.2.1. Company Snapshot
16.3.2. Interview Transcript: Ram Bhatt (Chief Executive Officer, Chairman and Founder)
17. APPENDIX 1: TABULATED DATA
18. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS
List Of Figures
Figure 3.1. Overview of Alzheimer’s Disease
Figure 3.2. Alzheimer’s Disease: Signs and Symptoms
Figure 3.3. Causes of Alzheimer’s Disease
Figure 3.4. Stages of Alzheimer’s Disease
Figure 3.5. Alzheimer’s Disease Management: Programs Undertaken by The National Institutes of Health
Figure 3.6. Alzheimer’s Disease Management
Figure 3.7. Digital Biomarkers in Alzheimer’s Disease
Figure 3.8. Potential of Digital Biomarkers in Alzheimer’s Disease
Figure 3.9. Sensors or Digital Senses in Wearable / Mobile Devices for Alzheimer’s Disease
Figure 4.1. Marketed and Clinical-Stage Drugs: Distribution by Phase of Development
Figure 4.2. Marketed and Clinical-Stage Drugs: Distribution by Type of Molecule
Figure 4.3. Marketed and Clinical-Stage Drugs: Distribution by Target Disease Stage
Figure 4.4. Marketed and Clinical-Stage Drugs: Distribution by Type of Treatment
Figure 4.5. Marketed and Clinical-Stage Drugs: Distribution by Mechanism of Action
Figure 4.6. Marketed and Clinical-Stage Drugs: Distribution by Route of Administration
Figure 4.7. Marketed and Clinical-Stage Drugs: Distribution by Dosing Frequency
Figure 4.8. Marketed and Clinical-Stage Drugs: Distribution by Type of Therapy
Figure 4.9. Marketed and Clinical-Stage Drugs: Distribution by Path to Clinic
Figure 4.10. Grid Analysis: Distribution by Phase of Development, Path to Clinic and Type of Therapy
Figure 4.11. Alzheimer’s Disease Therapies: List of Developers
Figure 4.12. Alzheimer’s Disease Therapy Developers: Distribution by Year of Establishment
Figure 4.13. Alzheimer’s Disease Therapy Developers: Distribution by Company Size and Geographical Location of Headquarters
Figure 4.14. Leading Players: Distribution by Number of Therapies
Figure 4.15. Alzheimer’s Disease Therapy Developers: Distribution by Geography
Figure 5.1. AbbVie: Financial Information
Figure 5.2. AC Immune: Financial Information
Figure 5.3. Biogen: Financial Information
Figure 5.4. Eisai: Financial Information
Figure 5.5. Eli Lilly and Company: Financial Information
Figure 5.6. GlaxoSmithKline: Financial Information
Figure 5.7. Grifols: Financial Information
Figure 5.8. Janssen Pharmaceutical: Financial Information
Figure 5.9. Neurim Pharmaceuticals: Financial Information
Figure 5.10. Novartis: Financial Information
Figure 5.11. Novo Nordisk: Financial Information
Figure 5.12. Roche: Financial Information
Figure 5.13. Takeda Pharmaceutical: Financial Information
Figure 6.1. Terminated Drugs: Distribution by Year of Discontinuation
Figure 6.2. Terminated Drugs: Distribution by Phase of Discontinuation
Figure 6.3. Terminated Drugs: Distribution by Mechanism of Action
Figure 6.4. Terminated Drugs: Distribution by Type of Indication
Figure 6.5. Terminated Drugs: Distribution by Reason for Termination
Figure 6.6. Terminated Drugs: Distribution by Affiliated Stakeholders
Figure 6.7. Terminated Drugs: Distribution by Study Start Year and Year of Termination of Clinical Trials
Figure 6.8. Terminated Drugs: Distribution by Location of Trials
Figure 7.1. Publication Analysis: Distribution by Year of Publication
Figure 7.2. Publication Analysis: Distribution by Key Focus Area
Figure 7.3. Publication Analysis: Word Cloud of Study Titles
Figure 7.4. Top Journals: Distribution by Number of Publications
Figure 7.5. Top Authors: Distribution by Number of Publications
Figure 8.1. Partnerships and Collaborations: Distribution by Year of Partnership
Figure 8.2. Partnerships and Collaborations: Distribution by Type of Partnership
Figure 8.3. Partnerships and Collaborations: Distribution by Type of Partnership and Focus Area of Partnership
Figure 8.4. Partnerships and Collaborations: Distribution by Type of Partnership and Type of Molecule
Figure 8.5. Most Active Players: Distribution by Number of Partnerships
Figure 8.6. Partnerships and Collaborations: Regional Distribution
Figure 8.7. Partnerships and Collaborations: Intercontinental and Intracontinental Agreements
Figure 9.1. Funding and Investment Analysis: Distribution by Year of Investment
Figure 9.2. Funding and Investment Analysis: Distribution by Amount Invested
Figure 9.3. Funding and Investment Analysis: Distribution by Type of Funding
Figure 9.4. Funding and Investment Analysis: Distribution by Amount Invested Across Different Types of Molecules
Figure 9.5. Funding and Investment Analysis: Distribution by Amount Invested Across Different Types of Mechanism of Action
Figure 9.6. Funding and Investment Analysis: Regional Distribution by Amount Invested
Figure 9.7. Most Active Players: Distribution by Number of Funding Instances
Figure 9.8. Most Active Investors: Distribution by Amount Funded
Figure 10.1. Grant Analysis: Distribution by Year of Grant Award
Figure 10.2. Grant Analysis: Distribution by Grant Amount Awarded
Figure 10.3. Grant Analysis: Distribution by Administering Institute Center
Figure 10.4. Grant Analysis: Distribution by Support Period
Figure 10.5. Grant Analysis: Distribution by Administering Institute Center and Support Year
Figure 10.6. Grant Analysis: Distribution by Type of Grant Application
Figure 10.7. Grant Analysis: Distribution by Grant Activity Code
Figure 10.8. Grant Analysis: Word Cloud of Study Titles
Figure 10.9. Grant Analysis: Distribution by Purpose of Grant Award
Figure 10.10. Grant Analysis: Distribution by Type of Recipient Organization
Figure 10.11. Popular NIH Departments: Distribution by Number of Grants
Figure 10.12. Prominent Program Officers: Distribution by Number of Grants
Figure 11.1. Clinical Trial Analysis: Distribution by Trial Status
Figure 11.2. Clinical Trial Analysis: Distribution by Trial Registration Year
Figure 11.3. Clinical Trial Analysis: Distribution by Type of Sponsor / Collaborator
Figure 11.4. Clinical Trial Analysis: Distribution by Type of Study Design
Figure 11.5. Clinical Trial Analysis: Distribution by Registration Year and Type of Study
Figure 11.6. Clinical Trial Analysis: Distribution by Patient Enrollment
Figure 11.7. Clinical Trial Analysis: Year-wise Trend of Completed and Recruiting Trials
Figure 11.8. Clinical Trial Analysis: Distribution by Age Category
Figure 11.9. Clinical Trial Analysis: Word Cloud of Study Titles
Figure 11.10. Most Active Industry Players: Distribution by Number of Registered Trials
Figure 11.11. Most Active Non-Industry Players: Distribution by Number of Registered Trials
Figure 11.12. Clinical Trial Analysis: Distribution by Trial Location
Figure 11.13. Clinical Trial Analysis: Distribution by Trial Status and Geography
Figure 12.1. Patent Analysis: Distribution by Patent Application Year
Figure 12.2. Patent Analysis: Distribution by Geography
Figure 12.3. Patent Analysis: Distribution by CPC Symbols
Figure 12.4. Word Cloud: Emerging Focus Areas
Figure 12.5. Patent Analysis: Distribution by Type of Applicant
Figure 12.6. Leading Players: Distribution by Number of Patents
Figure 12.7 Leading Players: Distribution by Number of International Patents
Figure 12.8. Patent Analysis: Patent Valuation Analysis
Figure 13.1. Non-Pharmacological Interventions for Alzheimer’s Disease
Figure 13.2. Cognition / Emotion-Oriented Interventions
Figure 13.3. Reminiscence Therapy
Figure 13.4. Simulated Presence Therapy
Figure 13.5. Sensory Stimulation-based Interventions
Figure 13.6. Virtual Reality
Figure 13.7. Music Therapy
Figure 13.8. Light Therapy
Figure 13.9. Aromatherapy
Figure 13.10. Reflexology
Figure 13.11. Other Psycho-social Interventions
Figure 13.12. Animal-Assisted Therapy
Figure 14.1. Global Alzheimer’s Disease Market, 2021-2030 (USD Million)
Figure 14.2. Global Alzheimer’s Disease Market, 2021-2030: Distribution by Type of Treatment (USD Million)
Figure 14.3. Global Alzheimer’s Disease Market, 2021-2030: Distribution by Type of Target Disease Indication (USD Million)
Figure 14.4. Global Alzheimer’s Disease Market, 2021-2030: Distribution by Geography (USD Million)
Figure 14.5. Alzheimer’s Disease Market in North America, 2021-2030 (USD Million)
Figure 14.6. Alzheimer’s Disease Market in North America, 2021-2030: Distribution by Type of Treatment (USD Million)
Figure 14.7. Alzheimer’s Disease Market in North America, 2021-2030: Distribution by Symptomatic Treatment (USD Million)
Figure 14.8. Alzheimer’s Disease Market in North America, 2021-2030: Share of Dementia in Symptomatic Treatment Market (USD Million)
Figure 14.9. Alzheimer’s Disease Market in North America, 2021-2030: Share of Insomnia in Symptomatic Treatment Market (USD Million)
Figure 14.10. Alzheimer’s Disease Market in North America, 2021-2030: Share of Other Psychological Symptoms in Symptomatic Treatment Market (USD Million)
Figure 14.11. Alzheimer’s Disease Market in North America, 2021-2030: Distribution by Disease Modifying Treatment (USD Million)
Figure 14.12. Alzheimer’s Disease Market in Europe, 2021-2030 (USD Million)
Figure 14.13. Alzheimer’s Disease Market in Europe, 2021-2030: Distribution by Type of Treatment (USD Million)
Figure 14.14. Alzheimer’s Disease Market in Europe, 2021-2030: Distribution by Symptomatic Treatment (USD Million)
Figure 14.15. Alzheimer’s Disease Market in Europe, 2021-2030: Share of Dementia in Symptomatic Treatment Market (USD Million)
Figure 14.16. Alzheimer’s Disease Market in Europe, 2021-2030: Share of Insomnia in Symptomatic Treatment Market (USD Million)
Figure 14.17. Alzheimer’s Disease Market in Europe, 2021-2030: Share of Other Psychological Symptoms in Symptomatic Treatment Market (USD Million)
Figure 14.18. Alzheimer’s Disease Market in Europe, 2021-2030: Distribution by Disease Modifying Treatment (USD Million)
Figure 14.19. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030(USD Million)
Figure 14.20. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Distribution by Type of Treatment (USD Million)
Figure 14.21. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Distribution by Symptomatic Treatment (USD Million)
Figure 14.22. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Share of Dementia in Symptomatic Treatment (USD Million)
Figure 14.23. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Share of Insomnia in Symptomatic Treatment (USD Million)
Figure 14.24. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Share of Other Psychological Symptoms in Symptomatic Treatment (USD Million)
Figure 14.25. Alzheimer’s Disease Market in Asia-Pacific, 2021-2030: Distribution by Disease Modifying Treatment (USD Million)
List Of Tables
Table 4.1 Alzheimer’s Disease: Marketed and Clinical Development Pipeline
Table 4.2 Alzheimer’s Disease Therapies: List of Developers
Table 6.1 Alzheimer’s Disease Therapies: List of Terminated Drugs
Table 7.1 Alzheimer’s Disease: List of Publications
Table 8.1 Alzheimer’s Disease: List of Partnerships and Collaborations
Table 9.1 Alzheimer’s Disease: List of Funding and Investments
Table 10.1 Alzheimer’s Disease: List of Academic Grants
Table 11.1 Alzheimer’s Disease: List of Clinical Trials
Table 12.1 Alzheimer’s Disease: List of Patents
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- AB Science
- AbbVie
- AC Immune
- ACADIA Pharmaceuticals
- Acelot
- Actinogen Medical
- Acumen Pharmaceuticals
- AFFiRiS
- AgeneBio
- Alector
- Alkahest
- Allergan (part of AbbVie)
- Allinky Biopharma
- Alterity Therapeutics (formerly known as Prana Biotechnology)
- Alzheimer's Association
- Alzheimer's Disease Cooperative Study (ADCS)
- Alzinova
- Alzprotect
- American Life Science Pharmaceuticals (ALSP)
- Amylyx Pharmaceuticals
- Anavex Life Sciences
- Aphios
- APRINOIA Therapeutics
- Archer Pharmaceuticals
- Ariana Pharma
- AriBio
- ArmaGen (acquired by JCR Pharmaceuticals)
- ARMGO Pharma
- Asceneuron
- AstraZeneca
- Athira Pharma (formerly known as M3 Biotechnology)
- Atridia
- Ausio Pharmaceuticals
- Autifony Therapeutics
- Avanir Pharmaceuticals
- Avid Radiopharmaceuticals
- Axon Neuroscience
- Axsome Therapeutics
- AZTherapies
- Banner Alzheimer's Institute
- Bausch Health
- Beacon Biosignals
- BELLUS Health
- BioArctic
- Biogen
- Biohaven
- Bionomics
- BioVie
- Bristol Myers Squibb
- Cambridge Quantum Computing (CQC)
- Cassava Sciences (formerly known as Pain Therapeutics)
- Celgene
- Cenna Biosciences
- CEOi
- Cerecin (formerly Accera)
- CereSpir
- CHA Biotech
- Chang Gung Memorial Hospital (CGMH)
- Changchun Huayang High-tech
- Chaperone Therapeutics
- Charsire Biotechnology
- Cogentis Therapeutics
- Cognition Therapeutics
- Cognosci
- CoMentis
- Corium International
- Cortexyme
- CuraSen Therapeutics
- Cure Alzheimer's Fund
- Cure Network Dolby Acceleration Partners (CNDAP)
- Cyclerion Therapeutics
- DAE HWA Pharmaceutical
- Denali Therapeutics
- Denovo Biopharma
- Edunn Biotechnology
- EIP Pharma
- Eisai
- Eli Lilly
- E-Scape Bio
- Evidation
- ExonHit Therapeutics (part of Sofinnova Partners)
- FUJIFILM Toyama Chemical
- GemVax & Kael
- Genentech
- Genervon Biopharmaceuticals
- Genzyme
- Gismo Therapeutics
- GlaxoSmithKline
- GliaCure
- GliaPharm
- Grifols
- HSRx Biopharmaceutical
- Hyundai Pharm
- IlDong Pharmaceutical
- Imeka
- INmune Bio
- Innovative California Biosciences International
- IntelGenx
- Intellect Neurosciences
- Intra-Cellular Therapies
- Ionis Pharmaceuticals
- IXICO
- Janssen Pharmaceuticals
- Johns Hopkins University
- KalGene Pharmaceuticals
- Karuna Pharmaceuticals
- Konkuk University Medical Center (KUMC)
- K-PAX Pharmaceuticals
- Kyowa Hakko Kirin
- Libella Gene Therapeutics
- Lipopharma
- Longeveron
- Lundbeck
- Lyndra Therapeutics
- MD Anderson Cancer Center
- Medesis Pharma
- Medipost
- Medpace
- Merck Sharp & Dohme
- Metabolic Solutions Development.
- Mission Therapeutics
- Mylan
- National Institute of Mental Health (NIMH)
- National Institute on Aging (NIA)
- National Institutes of Health (NIH)
- National Research Council Canada
- Nature Cell
- Neuralstem
- Neurim Pharmaceuticals
- NeuroActiva
- Neurocentria
- Neurodon
- NeuroGeneration
- NeuroGenetic Pharmaceuticals
- NeuroNascent
- NeurOp
- Neurotez
- NIH Clinical Center (CC)
- Novartis
- Novo Nordisk
- NYU Langone Health
- Orion Pharma
- Oryzon Genomics
- Otsuka Pharmaceutical
- P2D Bioscience
- Pfizer
- PharmatrophiX
- Pharmazz
- Pharnext
- Proclara Biosciences
- Procter & Gamble
- ProMIS Neurosciences
- Prothena
- QR Pharma
- Regenera Pharma
- RemeGenix
- ReMYND
- Reviva Pharmaceuticals
- Roche
- Sage Therapeutics
- Sahlgrenska University Hospital
- Sangamo Therapeutics
- Sanofi
- Selexis
- Shahid Sadoughi University of Medical Sciences and Health Services
- Shanghai Green Valley Pharmaceutical
- Shape Therapeutics
- Shionogi
- Sierra Sciences
- Sosei Heptares
- St Vincent’s Institute of Medical Research (SVI)
- Stemedica Cell Technologies
- Suven Life Sciences
- Synaptogenix (formerly Neurotrope Bioscience)
- T3D Therapeutics
- Taipei Veterans General Hospital (TVGH)
- Taiyo International
- Takeda Pharmaceutical
- TauRx Therapeutics
- Tetra Discovery Partners
- THERANEXUS
- Tonix Pharmaceuticals
- Treventis
- TrueBinding
- UCB
- University of California
- University of Kansas Medical Center (KUMC)
- University of Oslo
- University of Texas
- VA Office of Research and Development (ORD)
- Vaccinex
- Vaxxinity (formerly known as United Neuroscience)
- Vivoryon Therapeutics (formerly Probiodrug)
- Voyager Therapeutics
- VT BIO
- Worldwide Clinical Trials
- Wyeth
- Xcelthera
Methodology
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