Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction.
Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food.
Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction.
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Table of Contents
SECTION I1. Nutritional Support in Mitochondrial Diseases: The State of the Art
2. Targeting Mitochondrial Dysfunction: Challenges and Opportunities
3. Impact of Mitointeractions On Health-Disease Responses to Diet
4. Mitochondrion at the Crossroads Between Nutrients and Epigenome
5. Inadequate Nutritional Intake in Mitochondrial Diseases
6. Nutritional Deficits Involved in Mitocondrial Damage in Critical Illness
SECTION II
7. Mitochondrial Response to Controlled Nutrition in Health and Disease
8. Diet Restriction-Induced Mitochondrial Signalling and Healthy Aging
9. Ketogenic Diets, Mitochondria, and Neurological diseases
10. Ferility Diet and Mitochondrial Function
11. Maternal Nutrient Modulation and Fetal Mitochondrial Gene Expression
12. Dietary Modulation and Mitochondrial DNA Damage
SECTION III
13. Vitamin E, Mitochondrial Dysfunction and Aging
14. The Role of B Vitamins in Protecting Mitochondrial Function
15. Triggering Mitochondrion-Dependent Necrosis by Fatty Acids
16. Dietary Lipids and Mitochondrial Gene Expression
17. Dietary EPA and DHA for Mitochondrial Biosynthesis and Dynamics
18. Supplemental Vitamin C for Mitochondrial Biogenesis in Health and Exercise
SECTION IV
19. Mitochondria-Targeted Antioxidants: Coezyme Q10, MitoQ and beyond
20. Flavonoids, Mitochondrial Enzymes and Heart Protection
21. Tea Polyphenols Stimulate Mt Bioenergetics in Cardiometabolic Diseases
22. Quercetin and Mitochondria: from Nutrition to Nanomedicine
23. N-acetylcysteine and Up-Regulation of Mitochondrial Biogenesis
24. Dietary Carnitine, Mitochondrial Function and Therapy
25. Creatine Monohydrate for Mitochondrial Nutrition
26. Benefits of Supplemental Arginine and Citrullne in MELAS syndrome
27. Nutraceuticals for Targeting NAD+ to Restore Mitochondrial Function
28. Curcumin for Protecting Mitochondria and Down Regulating Inflammation
29. Dietary Molecular Hydrogen for Mitochondrial Viability
30. Fucoxantin and Mitochondrial Uncoupling Protein-1 in Obesity
31. Rice Bran Extract for the Prevention of Mitochondrial Dysfunction
32. Dietary Modulators of Nuclear Factor Erythroid-2-Related Factor 2
33. Plant Silymarin Affects Mitochondrial Integrity in Stress Conditions
34. Alternative Respiratory Chain Enzymes: Therapeutic Potential and Possible Pitfalls
35. New Mitochondria Permeability Transition Pore Inhibitor Based on Dietary Gallic Acid
36. Plant-Derived Compounds, Vitagens, and Mitochondrial Function
37. Buckwheat Trypsin Inhibitor (rBTI): A Novel Nutrceutical for Mitochondrial Homeostasis in Age-Related Conditions
38. Nutraceutical Effects of Indian Gooseberry on Mitochondria-Mediated Cellular Damage
39. 5-Heptadecylresorcinol from Whol Grain Rye for Mitochondrial Bioactivities
40. Combined Nutraceutical Therapy for Mitochondrial Cytopathies
