Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer's disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold's reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book.
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Table of Contents
1. Introduction: Microbial metabolite interference of protein biosynthesis in neurodegenerative, neurodevelopmental, and other disorders; microbial metabolites hijacking vagus nerve
2. COVID-19: Scientific progress
3. Viral-bacterial interactions in diseases
4. Vagus nerve: Acid reflux, parietal cells, carpal tunnel syndrome, Alzheimer's disease, COVID-19, stroke, cancer, and other diseases
5. Vagus nerve circuit: Microbiome-tryptophan metabolites-receptors and synapses
6. Glutamate and glutamate receptors in vagus nerve pathways and in Alzheimer's disease
7. Aminoacyl tRNA synthetase multiple forms in autoimmune and infectious diseases
8. Crystalized aromatic l-amino acid decarboxylase from bacteria Micrococcus percitreus catalyzing decarboxylation of tryptophan and l-DOPA (Levodopa or 3,4-dihydroxy-l-phenylalanine)
9. Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water
10. Microbial antigens, allergies, and antibodies to microbial allergens: Significance of preexisting antibodies and stress for vaccination
11. Smell and taste identification deficits in disease
12. Microorganisms producing biogenic amines: From food to human body
13. Human genome or human microbiome genes: Which one is more important for human health and intellectual abilities?
14. Microorganisms used in agriculture, consumed from environment and associated with the edible raw fruits, vegetables, herbs, sprouts, and mushrooms
15. Molecular and cell aggregation: Biogenic amines, proteins, platelets, and microbial pathogens
16. Colonic diverticular disease as a risk factor for neurodegenerative and associated diseases
17. Alzheimer's disease, dementia, aging, and COVID-19
18. Existing vaccines and new and old tools
19. Serotonin syndrome in neurodegenerative diseases and COVID-19: Mechanisms and consequences of intestinal infection
20. Circulating cell-free mitochondria and membrane vesicles
21. Protein synthesis inhibition in neuronal activities
22. Rosacea and associated medical disorders
23. Bacterial internalization in cancer and other medical conditions: Intracellular pathogens
24. Ocular changes resulting from reading and writing on smartphone and computer: Computer vision syndrome, dry eye disease, meibomian gland dysfunction, chalazion, occupational overuse syndrome
25. Viral infections in vagus nerve
26. Microbial tryptamine in Type 1, Type 2, and Type 3 diabetes
