The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology.
Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.
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Table of Contents
Part I. Progress in determining key elements in regulation of gene expression 1. Gene regulation in physiological processes 2. Epigenetics, the nonprotein coding genome, and human accelerated sequences
Part II. Evolution and adaptation 3. Gene expression and regulation relative to specific tissues and functions 4. Evo-Devo and morphological diversity 5. Adaptation and evolution 6. Adaptations metabolic and genomic to environmental changes
Part III. Adaptation 7. Regulatory elements relevant to brain, connectome, and neurodevelopmental disorders 8. Altered gene expression associated with developmental defects and disease 9. Metabolic, epigenetic functions and correlations with phenotype 10. Aging, genomic, mitochondrial, and regulatory changes
Part IV. Altered gene expression associated with developmental defects and disease 11. The regulatory genome and defects in monogenic diseases 12. Epigenetics and human disease 13. Connecting developmental defects and evolutionary findings 14. The regulatory genome and complex common diseases
Authors
Moyra Smith Professor Emerita, Department of Pediatrics and Human Genetics, College of Health Sciences, University of California, Irvine, CA, USA.Dr. Moyra Smith is a Professor Emerita in the Department of Pediatrics and Human Genetics, College of Health Sciences, at the University of California, Irvine, and in past years has held appointments at the National Institutes of Health and Johns Hopkins University. In 2017, the UCI Emeriti Association awarded Dr. Smith the UCI Outstanding Emerita Award in recognition of her continuing research on genetics and genomics, strong record of publications, active engagement with programs in the Department of Pediatrics, mentoring of graduate students, and involvement with the CART Autism Center at UCI. Dr. Moyra Smith has published more than 100 scientific articles in peer-reviewed journals such as Frontiers in Molecular Biosciences, Molecular Psychiatry, the Journal of Medical Genetics (JMG), and Cytogenetics Cell Genetics.
